4. Hrvatski kongres kliniËke citologije 4th Croatian Congress ... - Penta

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4. Hrvatski kongres kliniËke citologije / 1. Hrvatski simpozij analitiËke citologije / 2. Hrvatski simpozij citotehnologije URINE CYTOLOGY AS A FIRST AVAILABLE TOOL FOR DETECTION OF BK ASSOCIATED NEPHROPATHY-CASE REPORT Kovačević Vojtušek I1 , Knotek M1 , Ljubanović D2 , Kardum Skelin I1 , Sabljar Matovinović M1 , Vidas Ž1 1 University Hospital Merkur, Zagreb, Croatia, 2 University Hospital Dubrava, Zagreb, Croatia 130 Klinička citologija - Posteri Polyomavirus BK-associated nephropathy (PVAN), although first recognised in the late 1970-es, continues to represent a challenge in kidney transplantation, mainly because the optimal treatment approach has not been determined yet. The fact that about 10-30% of patients have simultaneously some stage of acute rejection, complicate the treatment even more. Herein we present a case of PVAN one year posttransplant, in the patient with combined liver and kidney transplantation, complicated by episode of acute T-cell mediated rejection. Identification of so-called decoy cells in the urine sediment of the patient with acute deterioration of graft function (eGFR from 71,5 to 56 ml/min) raised suspicion of PVAN, and diagnosis has been confirmed by histological finding of viral inclusions in renal tubular cells and immunohistochemical staining for poliomaviruses. The patient has been treated with leflunomide, intravenous immunoglobulin and reduction of overall immunosupression therapy. After short period (1,5 month) of stable renal function,further deterioration of graft function (eGRF 46,6ml/min) raised suspicion of acute rejection, which had been confirmed by patohistology. He received 500 mg of metilprednisolon intravenously and mycophenolatemofetil had been reintroduced, which resulted in slow partial recovery of the graft function, but never to the baseline values. For the past two years his renal graft function has been stable, maintaining lower levels of immunosupressive therapy. Conclusion: Prospective, multicentric studies are needed to assess different treatment approaches. Early diagnosis with close monitoring of renal function seems to represent the most efficacious tool in prevention of graft loss, but longer follow-up is necessary to determine the impact of immunosupression reduction on the long term graft outcomes. ikovacevicvojtusek@gmail.com
Clinical Cytology - Posters GRANULAR CELL TUMOR Lončar B1 , Marjanović K2 , Pauzar B1 , Staklenac B2 1Department of Clinical Cytology, University Hospital Osijek, Osijek, Croatia 2Department of Pathology and Forensic Medicine, University Hospital Osijek, Osijek, Croatia Granular cell tumors are relatively uncommon benign lesions occurring in almost any part of the body. We report the cytological diagnosis of granular cell tumor in 25-year-old male patient who presented with an inguinal mass clinically suspected to be a lymphadenopathy. Fine needle aspiration revealed polygonal cells with abundant, granular cytoplasm and eccentrically located vesicular nuclei and inconspicuous nucleoli. The histopathological examination of the surgical excision confirmed the diagnosis. If resection is complete, local surgical excision is curative for benign granular cell tumors. Granular cell tumor has a characteristic cytological appearance, and fine-needle aspiration cytology (FNAC) has been suggested to be diagnostic modality of choice. loncar.branka@kbo.hr KLINEFELTER SYNDROME AND ACUTE BASOPHILIC LEUKAEMIA - CASE REPORT Ljubić N1 , Lang N2 , Kardum Skelin I3 , Lasan R4 , Dominis M5 , Perković L1 , Županić-Krmek D2 , Grgurević-Batinica A1 1Department of Pathology and Cytology, General Hospital “Sveti Duh”, Zagreb, Croatia 2Department of Internal Medicine, General Hospital “Sveti Duh”, Zagreb, Croatia 3Division of Cytology, University Hospital “Merkur”, Zagreb, Croatia 4Department of Cytogenetic, Zagreb University Hospital Center, Zagreb, Croatia 5Department of Pathology and Cytology, University Hospital “Merkur”, Zagreb, Croatia Patients with 47, XXY karyotype (Klinefelter syndrome) appear to have increased risk of developing cancer, especially male breast cancer, germ cell tumours and non Hodgkin lymphomas, but rarely acute myeloid leukaemia. We report a patient with acute basophilic leukaemia with 47, XXY karyotype in both the tumour and constitutional cells. Acute basophilic leukaemia is very rare disease comprising less than 1% of all acute myieloid leukaemias. Morphological characteristic of leukaemic blast cells is moderately basophilic cytoplasm containing a variable number of coarse basophilic granules. The most characteristic cytochemical reaction is metachromatic positivity with toluidine blue. Blast are myeloperoxidase negative. Also leukemic blasts express myeloid and monocyte markers. There is no consistent chromosomal abnormality identified in this leukaemia. This is the first reported case of acute basophilic leukaemia in patient with Klinefelter syndrome. In this article the medical history of the patient is given and the possible connection between Klinefeter syndrome and acute myeloid leukaemia is discussed. nives.ljubic@zg.htnet.hr 131 4 th Croatian Congress of Clinical Cytology / 1 st Croatian Symposium of Analytical Cytology / 2 nd Croatian Symposium of Cytotechnology
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Final programme and abstract book
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UTORAK, 13.10.2009. SRIJEDA, 14.10.
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4. Hrvatski kongres kliniËke citologije 4th Croatian Congress ... - Penta

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