4. Hrvatski kongres kliniËke citologije 4th Croatian Congress ... - Penta

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4. Hrvatski kongres kliniËke citologije / 1. Hrvatski simpozij analitiËke citologije / 2. Hrvatski simpozij citotehnologije VULVAR PAGET’S DISEASE - CASE REPORT Katalenić Simon S, Krivak Bolanča I, Šentija K, Kukura V* Škrtic A** Laboratory for Cytology and Clinical Genetics *Department of Gynecology and Obstetrics **Department of Pathology and Cytology “Merkur“ University Hospital, Zagreb, Croatia 128 Klinička citologija - Posteri Vulvar Morbus Paget’s (MP) represents a rare intraepithelial adenocarcinoma. It appears in less than 5% of all vulvar neoplasia usually in postmenopausal women. Histological it is analogous to Paget’s disease of the breast. The most common clinical symptom is pruritus.The lesions appear as an erythematous or eczematous lesion with islands of hyperkeratosis. Occasionally, single anaplastic Paget’s cells can be found on the vulvar smears which make cytological diagnosis of the disease possible. However, the disease can be diagnosed only by biopsy. MP is classified into three distinct type based upon the origin of the neoplastic cell: type I - primary vulvar cutaneus Paget disease; type II - MP as a manifestation of an associated adjacent primary anal or rectal adenocarcinoma and type III - pagetoid urothelial intraepithelial neoplasia. To distinguish these subtypes the panel of immunohistochemistry markers must be done. We present a case of 49-year old woman with vulvar symptoms of pruritus, who had liver and kidney transplatation a two years ago. During the standard gynaecological examination the vulvar smear was taken for cytological evaluation. The smear was scanty, overload with squamae, with two kinds of cells: dysplastic squamous cells from lower layer of the epithelium and the single, anaplastic cells with enlarged nuclei, visible nucleoli and pale indistinct cytoplasm. According to that cytological diagnosis was vulvar intraepithelial lesions III (VIN III) with differential diagnosis of vulvar Paget disease. The pathological verification support the diagnosis of MP and an immunohistochemistry panel confirm type III of Paget disease so a evaluation of bladder was suggested. suzana.simon@kb-merkur.hr
Clinical Cytology - Posters SIMULTANEOUS OCCURRENCE OF CHRONIC LYMPHOCYTIC AND CHRONIC MYELOID LEUKEMIA Kojić Katović S1 , Vasilj A1 , Maričević I1 , Čaržavec D2 , Ćurić Jurić S1 1Department of Cytology, University Clinic of Internal Medicine, Sestre Milosrdnice University Hospital, Zagreb, Croatia 2Department of Hematology, University Clinic of Internal Medicine, Sestre Milosrdnice University Hospital, Zagreb, Croatia The coexistence of chronic lymphocytic (CLL) and chronic myeloid leukemia (CML) in the same patient has only been reported occasionally. Most of these cases represent the patients who developed CML during the cource of CLL. Reviewing the literature, only a few cases of simultaneous occurrence of CLL and CML was found. Here we represent a preveously fit 50-year old man in whom the diagnosis of CLL and CML was established by FNAB of the bone marrow. The diagnosis was then confirmed by histopathology, immunophenotypization of the peripheral blood and by cytogenetic study of the bone marrow. Four years after the diagnosis the patient is well, with leucocytosis of 40x109 , on the count of lymphocytes (93%). skojic@kbsm.hr 129 4 th Croatian Congress of Clinical Cytology / 1 st Croatian Symposium of Analytical Cytology / 2 nd Croatian Symposium of Cytotechnology
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Final programme and abstract book
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UTORAK, 13.10.2009. SRIJEDA, 14.10.
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4. Hrvatski kongres kliniËke citologije 4th Croatian Congress ... - Penta

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