4. Hrvatski kongres kliniËke citologije 4th Croatian Congress ... - Penta

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4. Hrvatski kongres kliniËke citologije / 1. Hrvatski simpozij analitiËke citologije / 2. Hrvatski simpozij citotehnologije 54 Klinička citologija - Plenarna i pozvana predavanja VALUE OF FINE-NEEDLE ASPIRATION CYTOLOGY IN DIAGNOSIS OF HODGKIN’S LYM- PHOMA AND ANAPLASTIC LARGE CELL LYMPHOMA: ONE CENTRE EXPERIENCE Ostojić Kolonić S1 , Prašek-Kudrna K1 , Roso V1 , Radić-Krišto D1 , Planinc-Peraica A1 , Džebro S2 , Kardum-Skelin I3 , Jakšić B1 1 Department of Medicine, University Hospital Merkur, Zagreb 2 Department of Pathology and Cytology, University Hospital Merkur, Zagreb 3 Laboratory for Cytology and Haematology, University Hospital Merkur, Zagreb It is commonly believed that cytological diagnosis of Hodgkin’s lymphoma (HL) is much easier than that of non-Hodgkin’s lymphoma (NHL). Anaplastic large cell lymphoma (ALCL) is NHL subtype which has created confusion with HL in fine-needle aspiration (FNA) smears. To study the value and limitations of cytology in diagnosis of HL and ALCL we analysed the initial FNA diagnosis and histopathological reports, as well as treatment and survival in 89 newly diagnosed consecutive patients with these lymphomas treated in our clinical department. These patients (40 male, 49 female; age range 16-93 years, mean 38 years; 44 in clinical stages I-II; 38 with B symptoms) were diagnosed and treated during a period of 5 years and 4 months (1.1.2004.-1.5.2009.) The initial FNA diagnoses were available in 86 patients (3 patients were admitted with histopathological diagnosis and without enlarged lymph nodes suitable for FNA) and the initial pathohistological diagnosis were available in 84 patients. FNA revealed 65 classic HL, 18 ALCL and 3 patients in which diagnosis was not informative due to inadequate material. Among 65 FNA diagnoses as HL, comparison with histopathology was made in 61 cases (in 3 cases a biopsy of lymph node was not possible and in one case there was no tumour infiltration in the analysed lymph node) and the histopathological diagnoses were as follows: 56 (91,8%) HL; 3 ALCL; 1 diffuse large B cell lymphoma and 1 marginal zone B cell lymphoma. In the group of 18 FNA diagnoses of ALCL 2 patients didn’t have a lymph node biopsy; in 1 case tumour was not found in biopsy material; 8 patients (53,3%) had definitive diagnosis of ALCL( either as T-cell or O type), and 5 (33,3%) as HL. These results confirm the value of FNA in diagnostic procedure in patients with HL and ALCL, with very good results in comparison with histopathology, especially in HL group of patients. 86 (96,6%) patients were treated with chemotherapy, 74 (83,1%) patients with ABVD chemotherapeutic protocol according to our policy that patients with HL and T-cell ALCL are treated with the same therapy as well. As we have almost uniform group of patients according to therapeutic approach, we done the univariante analyses and find out that patients with FNA diagnoses of HL, younger than 55 years, with early stage of the disease and without B symptoms had significantly longer overall survival (OS). FNA diagnosis has clinical relevance in differentiation between HL and ALCL. ostojic@net.hr
Clinical Cytology - Plenary and Invited Lectures ASSESSMENT OF HPV DNA TEST VALUE IN MANAGEMENT WOMEN WITH CYTOLOGI- CAL FINDINGS OF ASC-US, CIN1 AND CIN2 Pajtler M, Miličić-Juhas V, Milojković M, Topolovec Z, Čuržik D, Mihaljević I Department of Clinical Cytology, University Department of Gynaecology and Obstetrics, Clinical Institute of Nuclear Medicine and Radiation Protection, Osijek University Hospital, Osijek, Croatia The aim of this retrospective study was to answer the following questions: 1) is HPV DNA test for high-risk types able to predict lesion behaviour in women with cytological abnormalities lower than CIN3 (ASC-US, CIN1 and CIN2); 2) how to predict the histological diagnosis CIN3, and 3) is its use in diagnostic management in these patients justified or not? Subjects and Methods: The study included 345 women (11 ASC-US, 312 CIN1 and 22 CIN2) that underwent conventional diagnostic management (repeat cytology and colposcopy with or without histology) and HPV testing for high-risk HPV types by PCR method. The value of HPV DNA test in predicting lesion regression/persistence was assessed in 275 subjects without histology. In 70 subjects, diagnostic accuracy (sensitivity, specificity, and positive and negative predictive value) of repeat cytology and HPV DNA test in predicting severe intraepithelial lesion (CIN3) was determined on the basis of colposcopy guided biopsy. Results: The prevalence of persistent lesions was significantly higher in the group of HPV positive than in the group of HPV negative subjects (37.7% vs. 16.4%; P
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4. Hrvatski kongres kliniËke citologije 4th Croatian Congress ... - Penta

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