4. Hrvatski kongres kliniËke citologije 4th Croatian Congress ... - Penta

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4. Hrvatski kongres kliniËke citologije / 1. Hrvatski simpozij analitiËke citologije / 2. Hrvatski simpozij citotehnologije 94 Klinička citologija - Usmena predavanja PREVIOUS CYTOLOGICAL FINDINGS IN WOMEN WITH FINAL HISTOLOGICAL DIAGNOSIS OF CERVICAL INTRAEPITHELIAL NEOPLASIA GRADE 3 Milojkovic M1 , Pajtler M2 , Milojkovic D1 1 Department of Gynecology and Obstetrics, 2 Department of Clinical Cytology, Clinical Hospital Osijek Objective. To evaluate the reliability of the previous cytological smears in relation to the final histological diagnosis of cervical intraepithelial neoplasia grade 3 (CIN 3). In addition, to determine the importance of the follow up period and the number of cytological smears of patients with abnormal cytological findings in order to evaluate the lesion accurately. Methods. During the period 1 January 2000 – 31 December 2005, 805 women with a final histological diagnosis CIN 3 were analysed retrospectively. With regard to the length of the monitoring period before the histological verification, the women were classified in two groups: 1st group: less than a year, 2nd group: longer than a year. Results. During the monitoring period, 701 patients (87.1%) had a cervical finding of a high grade intraepithelial lesion (HIL) thus: only HIL (reliable cytological finding) in 357 women (44.3%) whereas 344 women (42.7%) had HIL and sometimes low grade intraepithelial lesion (LIL) and a normal finding (unreliable cytological finding). Cytological finding underestimated the histological one, only LIL or LIL/normal finding was found in 45 women (5.6%). The cytological finding suspicious for carcinoma (overestimated) was found in 20 (2.5%) women. The permanently normal cytological finding (false negative) had 8 (1.0%) women. The cytological finding was unknown in 31 (3.9%) women. For less than a year 470 (58.4%) women had been monitored cytologically (1st group). For more than a year 296 (36.8%) women had been monitored (2nd group). Conclusion. If the women with an abnormal cytological finding are monitored regularly and in continuity, the reliability of cytology in diagnostics of CIN 3 is high. Performing a single cytological screening is very unreliable. pajtler.marija@kbo.hr
Clinical Cytology - Oral Presentations FINE NEEDLE ASPIRATION CYTOLOGY OF ADRENOCORTICAL CARCINOMA: CASE REPORT Mišić M1 , Vidas Ž2 , Škegro D3 , Kocman B4 , Jelić-Puškarić B5 , Kardum-Skelin I5 1 General Hospital “Dr. J. Benčević”, Department of Cytology, Slavonski Brod 2 University Hospital Merkur, Division of Urology, Zagreb 3 University Hospital Merkur, Department of Medicine, Zagreb 4 University Hospital Merkur, Department of Surgery, Zagreb 5University Hospital Merkur, Department of Medicine, Laboratory for Cytology and Hematology, Zagreb, Croatia Adrenocortical carcinoma (ACC) is a malignant epithelial tumour of adrenal cortical cells. Approximately half of all ACCs are hormonaly functional. A 49-year-old woman presented for hirsutism, deep voice and hypertension. Ultrasonography (US) revealed a solitary tumor mass, 8 cm in size, of the right adrenal gland. Laboratory tests showed it to be a hormonally active, androgen secreting tumour (elevated testosterone level), which was consistent with the clinical picture of the disease. After histopathologic analysis tumor was signet out as adrenocortical carcinoma, a low risk carcinoma according to Weiss’ classification. On regular follow up US study performed at one year, a 65x43 mm growth was diagnosed in the lower pole of the right kidney. The finding was verified by computerized tomography and the patient was reoperated on. Exploration revealed secondary growth in the region of greater omentum, without infiltration of adjacent organs. Histopathologic analysis confirmed metastatic ACC. At 8 months of the second operation and after 6 chemotherapy cycles according to EAP protocol, enlarged paraaortic lymph nodes and a node along the upper pole of the right kidney were diagnosed by cytologic puncture. Cytologic analysis showed numerous large tumor cells (individual and in papillary clusters) with polymorphic, hyperchromic, irregular nuclei, prominent nucleoli with perinucleolar halo, and abundant pale basophilic cytoplasm. The cells were positive for vimentin, NSE, synaptophysin and epithelial markers (BerEP4 and epithelial membrane antigen - EMA). ACC is a rare tumor of high malignant potential. Morphologically (histopathology and cytology), there is the problem of differential diagnosis from adenoma on the one hand, and from renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC) on the other hand. A combined evaluation of clinical features , size or weight, microscopic appearance, immunohistochemical and molecular genetic data is necessary. maja.misic1@gmail.com 95 4 th Croatian Congress of Clinical Cytology / 1 st Croatian Symposium of Analytical Cytology / 2 nd Croatian Symposium of Cytotechnology
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Final programme and abstract book
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UTORAK, 13.10.2009. SRIJEDA, 14.10.
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4. Hrvatski kongres kliniËke citologije 4th Croatian Congress ... - Penta

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