4. Hrvatski kongres kliniËke citologije 4th Croatian Congress ... - Penta

Clinical Cytology - Plenary and Invited Lectures
CYTOLOGIC FOLLOW-UP IN WOMEN WITH CIN TREATED BY LETZ, COLD KNIFE
CONISATION AND SEMM’S COLD COAGULATION
Grubišić G, Kraljević Z, Vukosavić-Cimić B, Pirkić A, Grbavac I, Bolanča I
University Hospital “Sestre Milosrdnice” Zagreb
Aim. To compare follow-up cytology results in patient groups treated by LETZ (Loop
Excision of Transformation Zone), cold knife conisation and Semm’s cold coagulation
(Electro coagulation, ECG) according to CIN (Cervical Intraepithelial Neoplasia) on target
biopsy specimens, and definite therapeutic approach according to patient age, parity and
lesion grading. To evaluate therapeutic success in all three groups of patients regarding
to the control cytology findings. Patients and Methods. The study included patients
allocated to particular therapy group according to diagnostic and therapeutic guidelines
for preinvasive lesions of the uterine cervix from January 1, 1999 till December 31, 2000.
Results. LETZ was performed in 157, cold knife conisation in 42, and Semm’s cold coagulation
in 30 women. The patients mean age was 33,7 years in the LETZ group, 36,5
years in the cold knife conization group, and 30.0 years in the Semm’s cold coagulation
group. LETZ prevailed in young nulliparous women, and cold knife conization in parous
women. Cytology control underwent only 50 of 157 (32%) women with LETZ, 30 of 42 (71%)
women with cold knife conisation, and all 30 women with Semm’s cold coagulation. In
the LETZ group, 32 (64%) histology specimens revealed CIN III, whereas in the cold knife
conization group it was found in 22 (72%) women. Normal cytologic findings after above
mentioned procedures were recorded in 43 (88%) women from the LETZ group, 22 (73%)
women from the Semm’n cold coagulation group. LETZ under colposcopy guidance revealed
a high percentage of satisfactory cytologic follow-up.Conclusion. The importance
of the use of diagnostic and therapeutic guidelines and regular follow-up is emphasized,
bearing in mind primarily the young female population with severe preinvasive lesions of
uterine cervix. Under colposcopy guidance it is possible to obtain an optimal LETZ specimen
for histologic diagnosis. So, we report the satisfactory 88% rate of normal cytology
follow-up after LETZ procedure. However, the low rate of presentation for cytologic
controls in the LETZ group should stimulate us to invest additional efforts to achieve the
highest possible control visits in this very sensible population.
goran.grubisic@gmail.com
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4 th Croatian Congress of Clinical Cytology / 1 st Croatian Symposium of Analytical Cytology / 2 nd Croatian Symposium of Cytotechnology