4. Hrvatski kongres kliniËke citologije 4th Croatian Congress ... - Penta

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4. Hrvatski kongres kliniËke citologije / 1. Hrvatski simpozij analitiËke citologije / 2. Hrvatski simpozij citotehnologije 58 Klinička citologija - Plenarna i pozvana predavanja PRIMARY GASTROINTESTINAL NON HODGKIN LYMPHOMA IN ADULTS: CLINICOPATHOLOGICAL AND SURVIVAL CHARACTERISTICS Radić-Krišto D1 , Planinc-Peraica A1 , Ostojić Kolonić S1 , Vrhovac R1 , Kardum-Skelin I2 , Jakšić B1 1 Department of Hematology, University Hospital Merkur, Zagreb, Croatia 2 Department of Cytology, University Hospital Merkur, Zagreb, Croatia Primary non-Hodgkin lymphomas of gastrointestinal tract (PGI-NHL) are the most common extranodal lymphomas with increasing incidence. We retrospectively analyzed, incidence, clinicopathological features as well as treatement and survival data on 39, newly diagnosed PGI-NHL (23 male, 16 female), at University Hospital „Merkur“ in order to precisely evaluate their characteristics and compare them with results of other similar studies. The most common site of PGI-NHL was the stomach (29 patients, 74%), followed by small intestine (5 patients,13%), and colon and rectosigmoid (5 patints,13%). According to the Ann Arboror classification 34 (87%) patients had stage IE, and IIE, and 5 patients (12%) stages III E and IVE. According World Health Organization8 (WHO) classification 29 (87%) patients had diffuse large B-cell lymphoma (DLCBL), 2 had mantle cell lymphoma, and 7 (18%) had marginal zone B- cell lymphoma-mucosa associated tissue (MALT). Twenty six patients (66%) underwent surgical resection and were later treated by chemotherapy, 10 (26%), were treated with chemotherapy alone, and 3 (8%) were treated only surgical. Complete remissione was achived in 28 patients (72%), partial remission in 7 (18 %). Four patients had progressive disease (10%).The major prognostic factor for outcome in our patients was the stage of disease. Patients with localized lymphoma (stage IE and II E) had significantly longer overall survival (OS): 85% at 5-years and 65 % at 10 years. Patients with extended disease (stage IIIE and IV E) had overall survival less than 33%. Prognostic power of ESR, total protein and serum albumin, concentration and LDH activity, was analyzed. Among these parameters only parametars only LDH had statistically significant influence on overall survival. We conclude, that our group of patients is similar to other publised groups of PGI-NHL patients according to clinical characteristics as well as to pathological features. Disease stage and LDH were the only parametars that had a statistically significant influence on patients survival. delfaradic@kb.merkur.com
Clinical Cytology - Plenary and Invited Lectures SUBCUTANEOUS PANNICULITIS-LIKE T-CELL LYMPHOMA IN A 19 MONTH-OLD BOY TREATED WITH ALL-IC-BFM 2002 PROTOCOL - A CASE REPORT. Rajić Lj1 , Bilić E1 , Femenić R1 , Meštrović D1 , Ilić I2 , Kardum-Skelin I3 , Tešović G4 , Konja J1 1 Pediatric Clinic and 2 Department of Pathology, Clinical Hospital Center Zagreb 3 Clinical Hospital “Merkur“ 4 University Hospital for Infectious Diseases, Zagreb, Croatia. Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare type of T-cell lymphoma of CD3+CD8+ phenotype characterized by deep-seated skin nodules or plaques mimicking panniculitis, a result of neoplastic lymphocytes infiltrating the subcutaneous fatty tissue. SPTCL is very rare, especially in childhood (less than 1% of all non-Hodgkin lymphomas) and presents most commonly in young adults. Still, there are many uncertainties regarding the optimal therapy and definitive recommendations are still to be defined. Here we present a case of a 19-month year old boy with subcutaneous panniculitis-like T-lymphoma diagnosed and successfully treated in our institution. The disease presented with symptoms of high fever and a painful erythematous nodule located below the umbilicus. A thorough diagnostic workup was initiated and not even a month after the child was hospitalized a definite diagnosis of a subcutaneous panniculitis-like Tlymphoma was confirmed. As the most decisive in obtaining the diagnosis, skin biopsy showed infiltration of atypical, small to medium-sized lymphatic cells infiltrating the deeper dermal layers as well as the subcutaneous adipose tissue, surrounding the adipocytes. In addition, numerous hystiocytes and signs of cariorrhexis and focal necrosis were observed. No infiltration of blood vessels or epidermis was evident. We then initiated a specific treatment protocol for T-lymphomas (ALL-IC-BFM-2002) and saw a rapid regression of local symptoms. The treatment was completed according to schedule and the child is now, 14 months after the initiation of the treatment, in complete remission. ljubica.rajic@yahoo.com 59 4 th Croatian Congress of Clinical Cytology / 1 st Croatian Symposium of Analytical Cytology / 2 nd Croatian Symposium of Cytotechnology
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4. Hrvatski kongres kliniËke citologije 4th Croatian Congress ... - Penta

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