4. Hrvatski kongres kliniËke citologije 4th Croatian Congress ... - Penta

Clinical Cytology - Posters
NEONATAL HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS - CASE REPORT
Roganović J1 , Kvenić B1 , Jonjić N2 , Seili-Bekafigo I3 , Kardum-Skelin I4 1Division of Hematology and Oncology, University Children’S Hospital Rijeka;
2Department of Pathology, School of Medicine Rijeka;
3Department of Cytology, Department of Internal Medicine,
Clinical Hospital Centar Rijeka, Croatia
4Laboratory for Hematology and Cytology, Clinical Hospital Merkur, Zagreb, Croatia
Hemophagocytic lymphohystiocytosis (HLH) represents a severe hyperinflammatory
condition with the cardinal symptoms prolonged fever, hepatosplenomegaly, and cytopenias.
The most prominent histopathological feature is an accumulation of activated
T lymphocytes and macrophages predominantly in lymphoid tissues. Although it can occur
in all age groups, neonatal-onset HLH is very rare. We report on a case of HLH presenting
with anemia and respiratory distress at birth. Several weeks prior to diagnosis
the symptoms were attributed to a systemic infection. The child developed typical clinical
and laboratory findings, and was diagnosed with HLH according to the HLH-2004 guidelines.
Chemo-immunotherapy was initiated, but after a temporary control of the disease
he succumbed to rapidly progressive HLH. Post-mortem, extensive hemophagocytosis
was found in multiple organs. No specific genetic defect was identified.
HLH is potentially fatal childhood disease. It is important for pediatricians to be able
to early identify this disorder and commence the therapy before overwhelming disease
activity develops.
jelena.roganovic1@ri.t-com.hr
EOSINOPHILIC MASTITIS: A CASE REPORT OF AN EOSINOPHILIC MASTITIS IN
A 32-YEAR OLD FEMAL
Ropar S1 , Gredelj Šimec NJ2 , Tokić T2 1General Hospital Karlovac, Department for cytology, Karlovac, Croatia
2General Hospital Karlovac, Department of Internal Medicine, Karlovac, Croatia
Eosinophilic mastitis is a rare entity and mainly connected with significant eosinophilia
in peripheral blood. We have presented a case of eosinophilic mastitis which appeared
in a 32-year old female patient after unusually intense exposure to house dust. The disease
has manifested itself with redness and itching of the skin of both breasts, bilateral
retromamilar nodes painful to palpation, same as dense secretion from both breasts.
The cytological analysis of the breast’s secretion, same as the aspirate of a nodule of the
breast has shown numerous eosinophils, some phagocytes and numerous eosinophilic
granules. Eosinophilia was also present in the blood. Allergy against house dust was
proven with cutaneous prick test. A therapy with antihistamines led to total regression
of symptoms, same as to normalisation of laboratory results which convinced us in addition
that the case was related to eosinophilic mastitis.
samija66@gmail.com
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4 th Croatian Congress of Clinical Cytology / 1 st Croatian Symposium of Analytical Cytology / 2 nd Croatian Symposium of Cytotechnology