Student Project Abstracts 2005 - Pluto - University of Washington

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DEVELOPMENT OF EFFICIENT TWO-PHOTON RADICAL INITIATORS AND LOW SHRINKAGE MATERIALSproduct was extracted three times with EtOAc and then washedthree times with water. The organic layer was dried. The solidproduct was purified by column chromatography using EtOAc asthe eluent. The purified product was dried and a bright yellowsolid was collected (7.15g, 50.0%).4) 4-piperazinobenzaldehydePiperazine (20.8g, 0.242mol) was added to a solution ofK2CO3 (11,3g, 0.082mol) in 30mL DMSO. The reaction set toreflux under nitrogen. Once the reflux temperature was reached,4-fluorobenzaldehyde (8.5mL) in DMSO (10mL) was added.The reaction was refluxed overnight. Water was added (1150mL)and the solid product was filtered (9.02g, 58.9%).5) 4-N-t-butoxycarbonyl-N’-(p-formylphenyl)piperazine4-piperazinobenzaldehyde (9.02g, 0.047mol) was dissolvedin anhydrous DCM (112mL) under nitrogen. The solution wascooled to 0°C. After 20 minutes, triethylamine (6.6mL, 0.047mol)and di-t-butyldicarbonate (10.8mL, 0.047mol) was added. Thereaction was allowed to warm to room temperature and left overnight.The reaction mixture was washed three times with waterand dried. No product was obtained.6) N-(4-{(E)-2-{4-[4-(1-t-butoxycarbonyl)piperazin-1-yl]phenyl}ethenyl}-({[2,5-dimethoxyphenyl]ethenyl}phenyl)-N,N-dibutylamineDiethyl 4-{(E)-2-[4-(dibutylamino)phenyl]ethenyl}-2,5-dimethoxybenzylphosphonate (7.15g, 0.014mol) and 4-N-t-butoxycarbonyl-N’-(p-formylphenyl)piperazine(4.01g, 0.014mol)were added together in anhydrous THF (160mL). The mixturewas cooled to 0°C. After 20 minutes, tBuoK (1M, 14.5mL)was added. The reaction was run overnight. The reaction wasquenched with water (130mL). The product was then extractedwith EtOAc and washed several times with water. The organiclayer was dried. A column was run to purify the product usinghexane:EtOAc (5:1) as an eluent. The purified product was driedand a bright yellow solid was collected (6.07g, 66.4%)7) 4-N,N-(2,5-dimethoxy-4-{(E)-2-[4-piperazin-1-ylphenyl]ethenyl}ethenyl)anilineN-(4-{(E)-2-{4-[4-(1-t-butoxycarbonyl)piperazin-1-yl]phenyl}ethenyl}-({[2,5-dimethoxyphenyl]ethenyl}phenyl)-N,N-dibutylamine (6.07g, 0.0093mol) was dissolved in THF(200mL). HCl (2M, 60mL) was then added and the reaction washeated to reflux. After four hours, the reaction was allowed to coolto room temperature and left overnight. NaOH (2M, 65.6mL) wasthen added. The product was extracted with ether:DCM (8:2) andthen dried. Product was found to contain very few impurities, butwill be further purified before yield is determined.EXPERIMENTAL FOR LOWSHRINKAGE OLIGOMER1) p-t-butyl-calix[8]areneParaformaldehyde (17.5g, 0.55mol), p-t-butylphenol (50.0g,0.33mol), and NaOH (10M, 1mL) were added together in xylene(300mL). The reaction was heated to reflux. The reaction wasleft overnight and refrigerated for several hours, but no productformed.2) (1-bromo)butyl-(2-[3-oxetane])propyl ether1,4 dibromobutane (78.7mL, 0.58mol), 3-methyl-3-oxetanemethanol (20.0g, 0.20mol), NaOH (23.5g, 0.60mol), and TBAB(1.26g, 0.020mol) were added together in hexane (200mL) andwater (100mL). The reaction was heated to reflux and left overnight.The product was extracted with hexane and washed withwater. The organic layer was dried, leaving a pale brown liquid.The liquid was distilled using a full vacuum twice, but the productcould not be purified.3) octakis(t-butyl)-octakis[2-(3-oxetane)propyloxy]butoxycalix[8]areneP-t-butyl-calix[8]arene (0.500g, 0.00061mol), K2CO3(1.34g, .0098mol), and KI (0.563g, .0033mol) were added togetherin anhydrous DMF (15mL). The reaction was heated to 100°C.(1-bromo)butyl-(2-[3-oxetane])propyl ether (2.60g, 0.0098mol)in anhydrous DMF (10mL) was added dropwise. The reactionwas left overnight. No product formed.CONCLUSIONS AND OUTLOOKThe synthesis of the donor portion of the two photon radicalinitiator is nearly complete. The final crude product will be purifiedthrough recrystallization and the yield will be determined.The pure product will then attached to an acceptor molecule consistingof a fluoro-substituted triphenyl sulfur compound. Theresulting molecule will then be tested for its ability as a two photonradical initiator using UV-vis spectrometry. We believe thatthe molecule will absorb at a high peak wavelength, which willindicate a large amount of energy dissipated upon irradiation.The synthesis of the oligomer did not present any yield inany of the steps. For the first synthesis, a possible explanationis that the reaction is an equilibrium reaction with water as a byproduct.In order to drive the reaction to completion, water mustbe removed. This was not done the first time, so the synthesiswill be repeated using a Dean-Stark trap to remove water fromthe reaction mixture. The purification of the second synthesiswill be reattempted, and the temperature during the vacuum distillationwill be monitored more closely. After the first two productshave been obtained, the third experiment will be reattempted22 CMDITR Review of Undergraduate Research Vol. 2 No. 1 Summer 2005
using different reaction conditions, specifically a different base.Once the final oligomer has been synthesized, it will be testedfor volume shrinkage during crosslinking. The irradiated filmwill then be treated with organic solvent and the solubility of theoligomer will be tested.Future research will focus on the synthesis of other potentialefficient two photon radical initiators and low shrinkage materials.The results of the efficiencies of the products will be testedand compared to one another. Once we obtain an efficient radicalinitiator and low volume shrinkage material, the products will besynthesized on a large scale and distributed to various researchgroups to be used for experiments in other fields of photonics.ACKNOWLEDGEMENTSResearch support is gratefully acknowledged from the NationalScience Foundation Center on Materials and Devices forInformation Technology Research (CMDITR), DMR-0120967.COOPERCMDITR Review of Undergraduate Research Vol. 2 No. 1 Summer 2005 23
Page 2 and 3: The material is based upon work sup
Page 4 and 5: TABLE OF CONTENTSSynthesis of Dendr
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Page 8 and 9: SYNTHESIS OF DENDRIMER BUILDING BLO
Page 10 and 11: throughout the work period. Five su
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Page 14 and 15: BARIUM TITANATE DOPED SOL-GEL FOR E
Page 16 and 17: BARIUM TITANATE DOPED SOL-GEL FOR E
Page 18 and 19: SYNTHESIS OF NORBORNENE MONOMER OF
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Page 25 and 26: Synthesis of Nonlinear Optical-Acti
Page 27 and 28: quality of the XRD structures wasca
Page 29 and 30: Behavioral Properties of Colloidal
Page 32 and 33: Transmission electron microscopy ha
Page 36 and 37: areorient themselves with the elect
Page 38 and 39: Fabry-Perot modulators with electro
Page 42 and 43: QUANTIZED HAMILTON DYNAMICS APPLIED
Page 46 and 47: INVESTIGATING NEW CLADDING AND CORE
Page 48 and 49: Dr. Robert NorwoodChris DeRoseAmir
Page 50 and 51: SYNTHESIS OF TPD-BASED COMPOUNDS FO
Page 52 and 53: SYNTHESIS OF TPD-BASED COMPOUNDS FO
Page 54 and 55: OPTIMIZING HYBRID WAVEGUIDESpropaga
Page 56 and 57: At closer spaces the second undesir
Page 58 and 59: SYNTHESIS AND ANALYSIS OF THIOL-STA
Page 62 and 63: QUINOXALINE-CONTAINING POLYFLUORENE
Page 64 and 65: QUINOXALINE-CONTAINING POLYFLUORENE
Page 68 and 69: SYNTHESIS OF DENDRON-FUNCTIONALIZED
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BUILDING AN OPTICAL OXIMETER TO MEA
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TOWARD MOLECULAR RESOLUTION C-AFM W
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TOWARD MOLECULAR RESOLUTION C-AFM W
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SYNTHESIS AND CHARACTERIZATION OF E
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My name is Aaron Montgomery and I a
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1,1-DIPHENYL-2,3,4,5-TETRAKIS(9,9-D
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1,1-DIPHENYL-2,3,4,5-TETRAKIS(9,9-D
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EFFECTS OF SURFACE CHEMISTRY ON CAD
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EFFECTS OF SURFACE CHEMISTRY ON CAD
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SYNTHESIS OF A POLYENE EO CHROMOPHO
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SYNTHESIS OF A POLYENE EO CHROMOPHO
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CHARACTERIZATION OF THE MOLECULAR P
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OPTIMIZATION OF SEMICONDUCTOR NANOP
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OPTIMIZATION OF SEMICONDUCTOR NANOP
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CHARACTERIZATION OF THE PHOTODECOMP
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ELECTROLUMINESCENT PROPERTIES OF OR
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DETERMINATION OF MOLECULAR ORIENTAT
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DETERMINATION OF MOLECULAR ORIENTAT
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HYDROGEL MATERIALS FOR TWO-PHOTON M
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HYDROGEL MATERIALS FOR TWO-PHOTON M
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THE DESIGN OF A FLUID DELIVERY SYST
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THE DESIGN OF A FLUID DELIVERY SYST
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Student Project Abstracts 2005 - Pluto - University of Washington

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