2013-2014 Graduate Catalog Downloadable PDF (10.71MB)

352 Course Descriptions/BiochemistryBiochemistry(BICH)601. Fundamentals of Biochemistry I. (3-0). Credit 3. Basic biochemical concepts pertaining to thestructure of the major biomolecules (proteins, carbohydrates, lipids and nucleic acids); the relationshipof structure to function of these molecules; structure and action of enzymes; principles of bioenergetics.Prerequisite: One year of organic chemistry.602. Fundamentals of Biochemistry II. (3-0). Credit 3. Major metabolic pathways for carbohydrates,lipids, amino acids, proteins and nucleic acids, emphasizing oxidative processes and the biosynthesis ofRNA, DNA and protein; regulation of cellular metabolism. Prerequisite: BICH 601.603. General Biochemistry I. (3-0). Credit 3. The biochemical properties of macromolecules found in livingmatter; proteins, enzymes and nucleic acids. Prerequisites: BICH 410 or BICH 601; CHEM 228 andCHEM 323.605. Methods of Biochemical Analysis. (3-0). Credit 3. Experimental techniques important in biochemistryincluding methodologies for data analysis. Prerequisite: Graduate classification in biochemistry orapproval of instructor.608. Critical Analysis of the Biochemical Literature. (2-0). Credit 2. Reading and presentation of originalarticles in biochemistry and related fields to enhance understanding of experimental logic and scientificcommunication. Prerequisite: Graduate classification in biochemistry or approval of instructor.609. Preparation of a Biochemical Research Proposal. (2-0). Credit 2. Development and presentationof hypotheses, specific aims, significance and experimental approaches for a biochemical research proposal.Prerequisite: Graduate classification in biochemistry.624. Enzymes, Proteins and Nucleic Acids. (3-0). Credit 3. Chemical and physical properties of enzymes,proteins and nucleic acids; thermodynamics, kinetics and mechanisms of enzyme-catalyzed reactionsand protein-nucleic acid interactions. Prerequisites: BICH 603; CHEM 324.625. Nucleic Acid--Protein Interactions. (1-0). Credit 1. Mechanisms of nucleic acid-protein interactionsinvolved in fundamental biochemical processes such as DNA replication and rearrangement, transposition,transcription, RNA splicing and translation; original research articles presented focusing onexperimental approaches, interpretation of results and overall significance. Course may be taken 8 timesfor credit. Prerequisites: BICH 431 or GENE 431 or equivalent; approval of instructor. Cross-listed withMCMD 625.628. Computational Biology. (3-0). Credit 3. Introduction to computational biology; formulations of biologyproblems as computational problems; computational approaches to solve problems in genomics andproteomics. Prerequisite: Graduate classification or approval of instructor. Cross-listed with CSCE 628.631. Biochemical Genetics. (3-0). Credit 3. Genetic control of cellular metabolism; mechanism of geneaction; gene-enzyme relationships; regulation of gene expression; structure and organization of genomes;biochemical manipulation and characterization of genetic molecules. Prerequisites: BICH 431or GENE 431; BICH 603. Cross-listed with GENE 631.650. Genomics. (3-0). Credit 3. Modern genomics as a tool for understanding biological systems, genestructure, and organization as well as the history of sequencing technologies; focus on transcriptional,translational and functional genomics. Prerequisite: Graduate classification or approval of instructor.Cross-listed with BIOL 650.654. Structural Biochemistry. (3-0). Credit 3. Basic physics of X-ray diffraction, crystal structure methods,introduction to structural data bases, molecular geometry and molecular modeling. Prerequisite:Approval of instructor.655. Crystallography Methods. (2-3). Credit 3. The practice of x-ray diffraction in the study of biomolecules;solving protein crystal structures. Prerequisite: Graduate classification.661. Advanced Genome Annotation with Ontologies. (0-2). Credit 1. Advanced topics in functionalannotation using ontologies; usage issues and quality control for ontologies and annotations; mentoringannotation activities from BICH 460 and evaluation of annotations. May be taken three times for credit.Prerequisite: Graduate classification or approval of instructor.662. Eukaryotic Transcription. (1-0). Credit 1. Intensive short course in molecular mechanisms of eukaryotictranscription, and its regulation. Prerequisite: BICH 631 or GENE 631 or approval of instructor.Cross-listed with GENE 662.