PABI Plan - The Sarah Jane Brain Project

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1997 Margaret Faust Thesis Award, Scripps College 2000 Dissertation Research Award, American Psychological Association 2000 Graduate Research Award, APA, Retirement Research Foundation 2000 Sigma Xi, Grants in Aid of Research, National B. Selected peer-reviewed publications (in chronological order). Hartley AA, Little DM. (1999) Age-related differences and similarities in dual-task interference. J Exp Psychol Gen;128(4):416-49. Little DM, Hartley AA. (2000) Further evidence that negative priming in the Stroop color-word task is equivalent in older and younger adults. Psychol Aging; 15:9-17. Wingfield A, Prentice K, Koh CK, Little DM. (2000) Neural change, cognitive reserve and behavioral compensation in rapid encoding and memory for spoken language in adult aging. In L. T. Connor & L. K. Obler (Eds.) Neurobehavior of Language and Cognition: Studies of Normal Aging and Brain Damage. Little DM, Prentice KJ, Wingfield A. (2004) Adult age differences in judgments of semantic fit. Appl Psycholinguistics; 25: 135-143. Little DM, Klein R, Shobat DM, McClure E, Thulborn KR. (2004) Changing patterns of processing during category learning observed by functional MRI. Cognitive Brain Research; 22: 84-93. Laatsch L, Little DM, Thulborn KR. (2004) Changes in fMRI following cognitive rehabilitation therapy in severe traumatic brain injury: A case study. Rehabilitation Psychology; 49: 262-267. Little DM, Prentice KJ, Darrow AW, Wingfield A. (2005) Listening to spoken text: adult age differences as revealed by self-paced listening. Exp Aging Res; 31:313-30. Little DM, Thulborn KR. (2005) Correlations of cortical activation and behavior during the application of newly learned categories. Cognitive Brain Research 25: 33-47. Little DM, McGrath LM, Prentice KJ, Wingfield A. (2006) Semantic encoding of spoken sentences: Adult aging and the preservation of conceptual short term memory. Appl Psych; 27: 487-511. Gussin HA, Tomlinson ID, Little DM, Warnement MR, Qian H, Rosenthal SJ, Pepperberg DR. (2006) Binding of muscimol-conjugated quantum dots to GABAC receptors. Am Chem Soc; 128:15701-13. Kuhlman A, Little D, Sekuler R. (2006) An interactive test of serial behavior: age and practice alter executive function. J Clin Exp Neuropsychol; 28:126-44. Little DM, Shin SS, Sisco SM, Thulborn KR. (2006) Event-related fMRI of category learning: Differences in classification and feedback networks. Brain and Cognition 60: 244-252. Little DM, Thulborn KR. (2006) Prototype-distortion Category Learning: A Two-phase Learning Process across a Distributed Network. Brain and Cognition 2006; 60: 233-243. Tomlinson ID, Gussin HA, Little DM, Warnement MR, Qian H, Pepperberg DR, Rosenthal SJ. (2007) Imaging GABA(c) Receptors with Ligand-Conjugated Quantum Dots. J Biomed Biotechnol; 2007:76514. Kraus MF, Susmaras T, Caughlin BP, Walker CJ, Sweeney JA, Little DM. (2007) White matter integrity and cognition in chronic traumatic brain injury: a diffusion tensor imaging study. Brain; 130(Pt 10):2508-19. Kraus MF, Little DM, Donnell AS, Reilly J, Sisco S, Simonian N, Kay M, Khine T, Sweeney J. (2007) Oculomotor function in chronic traumatic brain injury. Cognitive and Behavioral Neurology; 20: 170-179. Kang Derwent JJ, Saszik SM, Maeda H, Little DM, Pardue MT, Frishman LJ,Pepperberg DR. (2007) Test of the paired-flash electroretinographic method in mice lacking b-waves. Vis Neurosci; 24:141-9. Little DM, Holloway R. (2007) Diffusion Tensor Imaging: Scientific advance, clinical tool, or just a pretty picture. Neurology 2007; 68: 9-10. Little DM, Thulborn KR, Szlyk JP. (2008) An fMRI study of saccadic and smooth pursuit eye movement control in Age-Related Macular Degeneration. Investigative Ophthalmology and Visual Sciences 49: 1728- 1735. Pawar AS, Qtaishat NM, Little DM, Pepperberg DR. (2008) Recovery of rod photoresponses in ABCR-deficient mice. Invest Ophthalmol Vis Sci; 49:2743-55. Prodoehl J, Yu H, Little DM, Abraham I, Vaillancourt DE. (2008) Region of interest template for the human basal ganglia: Comparing EPI and Talairach approaches. NeuroImage 39(3): 956-965.
Maki PM, Cohen M, Weber K, Little DM, Fornelli D, Perschler P, Gould F, Martin E. (2009) Deficits in verbal memory and hippocampal function in HIV-positive women. Neurology; 72:1661-8. Vaillancourt DE, Spraker MB, Prodoehl J, Abraham I, Corcos DM, Zhou XJ, Comella CL, Little DM. (2009) High resolution diffusion tensor imaging in the substantia nigra of de novo Parkinson’s disease. Neurology, Jan 7 [Epub ahead of print] Szlyk JP, Little DM. (2009) An fMRI Study of Word-Level Recognition and Processing in Patients with Age- Related Macular Degeneration. Invest Ophthalmol Vis Sci; Apr 22 [Epub ahead of print]. C. Research Support Ongoing Research Support: R21 AG028662 Little (PI). Anatomical correlates of executive function decline in normal aging, NIH/NIA, 2007-2009. The goal of the project is to determine the relative roles of axonal versus neuronal loss in normal aging as they relate to behavioral declines in so-called executive functions. To do this we plan to use standard structural MRI, fMRI, and high-resolution DTI in super-healthy younger adults, middle-aged adults, and older adults. There is no overlap with the current proposal. There is no overlap with the proposed research. Role: Principle Investigator, 32% Effort High Resolution Diffusion Tensor Imaging of White Matter Integrity in Mild TBI, CINN Foundation, 2007- 2009. The goal of the project is to examine the contributions of axonal injury and myelin damage to sustained cognitive deficits in patients who have sustained a single, closed-head, mild traumatic brain injury. To do this, we plan to use detailed neuropsychological testing, a neurobehavioral interview, as well as high resolution diffusion tensor imaging in groups of healthy controls and in patients with brain injuries. This grant provided pilot data for the current proposal. There is no overlap with the proposed investigation. Role: Principle Investigator, No Salary Support High Resolution Diffusion Tensor Imaging of Cortical-Subcortical White Matter Tracts in TBI, Department of Defense 2008-2011 The goal of the project is to examine the effects of TBI on white matter tracts which connect cortical to subcortical structures. To do this, we plan to use high resolution diffusion tensor imaging in groups of healthy controls and in patients with brain injuries. This grant has a focus on basic methodological development which supports the current investigation. Role: Principle Investigator, 25% Effort Scaling and sequencing motor output in humans: an fMRI and DTI study. Pending. 2009-2013 National Institute of Neurological Disorders and Stroke This grant sets out to characterize structural integrity of the basal ganglia in patients with parkinson’s disease and relate changes in structural integrity to functional alteration in function. There is no overlap with the proposed research. Role: Co-Investigator, 5% Salary
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The Honorable Kathleen Sebelius Sec
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promote the integration and full in
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The National Pediatric Acquired Bra
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Phase Three consisted of having the
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the fact that their brains are stil
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methods developed by the SJBP to sh
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Two-Year Milestones Quarter 1: •
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Figure 2: CDC figures for death and
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PA/TBI and their families, delivere
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appropriately in the care of the ch
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CHAPTER 2: The TBI Model System and
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2. States need to “buy” into id
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implications of shaking a baby; and
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service was developed for children
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a. There is a lack of evidence for
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8. In addition, ongoing education a
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While there are often significant i
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are largely unknown. In particular,
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Family Perspective: Without early i
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4. Improve the specific identificat
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unemployment, public-assisted housi
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REFERRAL FROM ACUTE CARE, REHABILIT
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understanding determinants of long-
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Research - Increase capacity of loc
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Alternatively, indirect effects on
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Specific questions regarding tracki
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CHAPTER 7: Categories of Care: Tran
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care of syndromes associated with a
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Social Opportunities The services a
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Finally, a third area of problem af
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CHAPTER 8: Category of Care: Rural/
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• Lack of public transportation
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• Provide consequences for wastin
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Rural / Tele-health issues during A
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educated and thus are less aware of
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Chapter 9: Category of Care: The Vi
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"To improve the quality of our heal
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Registry technology has been used a
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CHAPTER 10: Organizational Structur
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Northeast Region: New York Mid-Atla
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State IT Manager: primary responsib
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translational data for their Catego
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CHAPTER 11: Financing the PABI Plan
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projects, a smaller state will have
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Summary of PABI Grant Proposal cont
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Sarah Jane Brain Family State Lead
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The University of Alabama at Birmin
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h Principal Investigator/Program Di
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The Children's Hospital at Providen
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Barrow Neurological Institute / St.
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Employment Education Postgraduate T
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Certifications Neuroscience Grand R
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UAMS/Arkansas Children's Hospital R
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Program Director/Principal Investig
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C. Research Support Ongoing Researc
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Mattel Children's Hospital UCLA Pro
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BIOGRAPHICAL SKETCH Provide the fol
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17. Madikians A and Giza CC. A Clin
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The Children's Hospital Profile con
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CURRICULUM VITAE JEANNE E. DISE, Ph
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Curriculum Vitae Jeanne E. Dise Pag
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Yale‐New Haven Children's Hospita
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Yale‐New Haven Children's Hospita
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2001 - Associate Professor, Sect of
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Major goal: to provide education in
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Nemours / Alfred I. duPont Hospital
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Joseph A. Iocono, M.D Curriculum Vi
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Louisiana Health Care Quality Forum
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Shannon Robshaw, MSW is the Executi
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Maine Institute of Human Genetics a
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Maine Institute of Human Genetics a
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Principal Investigator/Program Dire
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Kennedy Krieger Institute Profile c
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Kennedy Krieger Institute Profile c
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Children's Hospital of Boston and H
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Date Updated: November 5, 2008 CURR
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2001- Member, Advisory Committee Ha
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underway to best direct prevention
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2. Mooney DP, Lewis JE, Connors RH,
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Date Prepared: January 5, 2009 Name
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Regional 2006- Vice President of Ma
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Honors and Prizes Year Name of Hono
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2000 Pediatric Spine Injuries Singl
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2006 Infant Skull Deformities Pedia
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2002 Management of Sports-related C
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Clinical Innovations I have been ab
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10. Dunn IF, Proctor MR, Day AL. Lu
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Trauma Surgery, Neurology, Neuropsy
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Michigan Public Health Institute an
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Michigan Public Health Institute an
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Vonderheid, S.C., Pohl, J. M., Tann
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Mayo Clinic Profile continued Title
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Mayo Clinic Profile continued Title
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LICENSURE Minnesota HONORS/AWARDS S
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Spina Bifida in Adulthood Physical
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Sherilyn W. Driscoll, MD Page 6 of
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-Implementation of new pediatric wh
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BIBLIOGRAPHY Peer-reviewed Articles
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Children's Rehabilitation Services
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Curriculum Vitae Shannon Janine Smi
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Shannon Janine Smith, MD Page 2 Hon
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Center, Pediatric Grand Rounds Shan
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Saint Louis Children's Hospital Pro
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Saint Louis Children's Hospital Pro
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Completed Research Support Principa
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Montana State University Billings /
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Montana State University Billings /
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• Region IV Paraeducator Summer I
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Madonna Rehabilitation Hospital Pro
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Madonna Rehabilitation Hospital Pro
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Staff Occupational Therapist: 1997-
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Sunrise Children's Hospital Profile
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Sunrise Children's Hospital Profile
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Brain Injury Association of New Jer
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Biographical Sketch Barbara Geiger-
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University of New Mexico School of
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Mount Sinai Medical Center Profile
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The Clinical Center for the Study o
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NAME Stephen R. Hooper eRA COMMONS
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Hooper, S.R., Hatton, D., Schaaf, J
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Still pending Profile continued Tit
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Cincinnati Children's Hospital Medi
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CURRICULUM VITAE NAME Stanley E. Gr
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Courtesy Staff, 1990-1998 Leave of
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OSU-CHS International Medicine Club
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ViroPharma Protocol 637-303: Princi
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Teaching Research Institute and Wes
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Voss, J., Stevens, T., Glang, A., &
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Children's Hospital of Pittsburgh o
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BIOGRAPHICAL SKETCH Provide the fol
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C. Research Support. List selected
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Puerto Rico Medical Center / Univer
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Puerto Rico Medical Center / Univer
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LICENCE TO PRACTICE MEDICINE: (plac
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REFERENCES Dr. Nathan Rifkinson, UP
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Hasbro Children's Hospital Child Pr
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Hasbro Children's Hospital Child Pr
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1990-1996 Director of Medical Progr
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infant death and suspected physical
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Medical University of South Carolin
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Medical University of South Carolin
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Role: PI Principal Investigator/Pro
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Center for Disabilities / Sanford S
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Center for Disabilities / Sanford S
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• February 2004 - May 2005: Indep
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• September 2008: Presentation at
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• Coordinator for LEND (The South
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University of Tennessee Profile con
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University of Tennessee Profile con
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4. Johnson, R. K., Hough, M. S., Ki
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Center for BrainHealth / The Univer
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Center for BrainHealth / The Univer
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McCauley, S.R., McDaniel, M.A., Ped
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Levin, H. S., Mendelsohn, D. B., Li
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University of Utah Profile continue
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University of Utah Profile continue
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5. Statler KD, Jenkins LW, Dixon CE
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F. Invited Presentations Internatio
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The Vermont Center for Children, Yo
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The Vermont Center for Children, Yo
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2006-Present Chairman of the Child
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Abdellaoui A, Bartels M, Hudziak JJ
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UVA Children's Hospital and Kluge's
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UVA Children's Hospital and Kluge's
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B. Selected peer-reviewed publicati
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University of Washington / Harborvi
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University of Washington / Harborvi
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West Virginia Brain Injury Associat
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Children's Hospital of Wisconsin Pr
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Children's Hospital of Wisconsin Pr
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Brain Injury Association of Wyoming
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EDUCATION Dorothy Worrell 2302 Sage
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of Developmental Disabilities; assi
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PUBLICATIONS Member of VISIONS Admi
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n/a Profile continued Title/Descrip
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References 1. Adelson, P.D. (2008).
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30. Centers for Disease Control and
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62. Haddon, W. (1973). Energy damag
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96. Perel, P., Yanagawa, T., Bunn,
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