PABI Plan - The Sarah Jane Brain Project

Principal Investigator/Program Director (Last, First, Middle):
18. Albayram S, Melhem ER, Mori S, Zinreich SJ, Barkovich AJ, Kinsman SL. Diffusion tensor MR
Imaging of white matter tracts of the brainstem in children with Holoprosencephaly: Initial
experience. Radiology, 223:645-51, 2002.
19. Barkovich AJ, Simon EM, Clegg NJ, Kinsman SL, Hahn JS. Analysis of the cerebral cortex in
holoprosencephaly with attention to the sylvian fissures. Am J Neuroradiol, 23:143-50, 2002.
20. Plawner LL, Delgado MR, Miller VS, Levey EB, Kinsman SL, Barkovich AJ, Simon EM, Clegg
NJ, Sweet VT, Stashinko EE, Hahn JS. Neuroanatomy of holoprosencephaly as predictor of
function: beyond the face predicting the brain. Neurology, 59:1058-66, 2002.
21. Barkovich AJ, Simon EM, Glenn OA, Clegg NJ, Kinsman SL, Delgado M, Hahn JS. MRI shows
abnormal white matter maturation in classical holoprosencephaly. Neurology. 2002 Dec
24;59(12):1968-71.
22. Takahashi T, Kinsman S, Makris N, Grant E, Haselgrove C. McInerney S, Kennedy DN,
Takahashi T, Fredrickson K, Mori S, Caviness VS. Semilobar Holoprosencephaly With
Midline “Seam”: A topologic and morphogenetic model based upon MRI analysis. Cerebral
Cortex December 2003; 13:1299-1312.
23. Zabel TA, Ries J, Mahone EM, Demetrides S, Levey E, Kinsman SL. The Kennedy
Independence Scales--Spina Bifida Version: a parent report rating scale of adaptive functioning
in adolescents with spina bifida. Eur J Pediatr Surg. 2003 Dec;13 Suppl 1:S37-9.
24. Takahashi TS, Kinsman S, Makris N, Grant E, Haselgrove C, McInerney S,Kennedy DN,
Takahashi TA, Fredrickson K, Mori S, Caviness VS. Holoprosencephaly--topologic variations
in a Liveborn series: a general modelbased upon MRI analysis. J Neurocytol. 2004
Jan;33(1):23-35.
25. Kinsman, SL. White matter imaging in holoprosencephaly in children. Curr Opin Neurol. 2004
Apr;17(2):115-9.
26. Steele-Perkins G|, Plachez C, Butz KG, Yang G, Bachurski CJ, Kinsman S, Litwack ED, Ric LJ
and Grohardsnostajski RM. The transcription factor Nfib is essential for both lung maturation
and brain development. Mol Cell Biol. 2005 Jan;25(2):685-98.
27. Ren T., Anderson A., Shen, W.B., Huang H., Plachez C., Kinsman S.L., Richards L.J. Imaging,
anatomical and molecular analysis of callosal formation in the developing human fetal brain. Anat Rec
A Discov Mol Cell Evol Biol. 2006 Feb;288(2):191-204.
28. Hahn J.S., Barkovich A.J., Stashinko E.E., Kinsman S.L., Delgado M.R., Clegg N.J. Factor analysis of
neuroanatomical and clinical characteristics of holoprosencephaly. Brain Dev. 2006 Aug;28(7):413-9.
C. Research support
Ongoing Research Support
Funded Support
Completed Research Support
R21 NS045841-01 Richards (PI) 03/01/03 – 02/28/06
NINDS
Development of the Human Corpus Callosum
The Goal of this project is to study the molecular and cellular mechanisms involved in forming the human
corpus callosum.
Role:Co-Investigator
Kinsman (PI) 1/01/1999 – 6/30/2002
The Don and Linda Carter Foundation - Denton, Texas
The Carter Center for Brain Research in Holoprosencephaly and Related Malformations at Kennedy Krieger
Institute
This center has built a clinical and research base for this rare birth defect that draws on a regional and national
level and studies neuroimaging/neuroanatony, genetics, and clinical aspects of the condition.
PHS 398/2590 (Rev. 09/04) Page Continuation Format Page