PABI Plan - The Sarah Jane Brain Project

Principal Investigator/Program Director: Pineda, Jose A.
(Last, first, middle)
14. Lewis SB, Velat GJ, Miralia L, Papa L, Aikman JM, Wolper RA, Firment CS, Liu MC, Pineda JA, Wang
KK, Hayes RL.Alpha-II spectrin breakdown products in aneurysmal subarachnoid hemorrhage: a novel
biomarker of proteolytic injury. J Neurosurg. 2007 Oct;107(4):792-6
15. Dean NP, Boslaugh S, Adelson PD, Pineda JA, Leonard JR. Physician agreement with evidencebased
recommendations for the treatment of severe traumatic brain injury in children. J Neurosurg.
2007 Nov;107(5):387-391
16. Leonard J, Leonard J, Ray WZ, Pineda JA. Traumatic brain injury in children. Mo Med. 2008 Sep-
Oct;105(5):404-11; quiz 411-2.
17. Brophy GM, Pineda JA, Papa L, Lewis SB, Valadka AB, Hannay HJ, Heaton SC, Demery JA, Liu MC,
Tepas JJ, Gabrielli A, Robicsek S, Wang KK, Robertson CS, Hayes RL. AlphaII-Spectrin Breakdown
Product Cerebrospinal Fluid Exposure Metrics Suggest Differences in Cellular Injury Mechanisms after
Severe Traumatic Brain Injury. J Neurotrauma. 2009 Apr;26(4):471-9.
Invited Publications:
1. Pineda, JA, Book Review: Traumatic Head Injury in Children. Archives of Pediatrics & Adolescent
Medicine. 1997; 151(12):1271
2. Pineda JA: The Future of Traumatic Brain Injury: How Will It Fit Children. Brain Injury Source. Winter
2002; 6(1): 28-30
3. Pineda JA, Zaritsky AL: The relationship of oxygen consumption to cerebral functional activity. The
Journal of Pediatrics 2004; 144(1): 29
4. Pineda JA, Wang KWW, Hayes RL: Biomarkers Of Proteolytic Damage Following Traumatic Brain
Injury. Brain Pathology 2004; 14(2): 202-9
5. Pineda JA, Tepas JJ: Caring for the child with severe traumatic brain injury: Old lessons learned and
new concepts (Editorial). Pediatr Crit Care Med. 2006 Sep;7(5):496-7.
C. Research Support
Ongoing Research Support
Harold Amos Medical Faculty Role: PI 7/1/2009- 6/30/2013
Development Program,
Robert Wood Johnson Foundation
Title: Imaging mitochondrial dysfunction in pediatric brain injury: Impact on outcomes
Project Goals: to use MRI spectroscopy techniques in children with TBI to 1) more accurately evaluate acute
and sub-acute prognosis; and 2) delineate potential therapies addressing mitochondrial dysfunction.
National Institutes of Health Role: Site PI 5/1/2008-4/30/2013
Title: Pediatric TBI Consortium: Hypothermia
Project Goals: multicenter Phase III RCT to test the hypothesis that moderate hypothermia after severe TBI in
children will improve mortality and functional outcome.
Principal Investigator: P. David Adelson, MD University of Pittsburgh
National Institutes of Health Role: Scholar 7/1/2007-7/1/2010
Title: K12 Multidisciplinary Clinical Research Career Development Program
Project Goals: to explore mechanisms of brain metabolic dysfunction and related cell death in children with
severe TBI. Coursework and mentored activities for conferral of a MsC degree in Clinical Investigation.
Principal Investigator: Victoria Fraser, M.D.
National Institutes of Health/ CDC Role: Site PI
Title: Critical Pertussis in U.S. Children: Severe Morbidity, Sequelae, and Mortality: A Prospective Cohort
Study
Project Goals: multicenter prospective cohort study is to describe the societal burden of severe pertussis in the
US pediatric population from clinical and health outcome perspectives.
PHS 398/2590 (Rev. 11/07) Page ___ Other Support Format Page