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New to the Third Edition The Third Edition of Antibiotics Simplified expands on the drug classes covered in the first while retaining the “key point” focus of the text that has made it successful. The Third Edition includes expanded coverage of antiviral agents, particularly new-andold treatments for hepatitis B and C infections. New antibiotics have been added since the Second Edition, and the chapters for each class were updated with new clinical and scientific findings. xiii
Page 1 and 2: Antibiotics Simplified third EDITIO
Page 3 and 4: Contents Acknowledgments Introducti
Page 5 and 6: Contents v Chapter 28: Antifungal A
Page 7: Acknowledgments Our thanks go to th
Page 10 and 11: x Introduction ■■ How to Use Th
Page 15: Considerations with Antibiotic Ther
Page 18 and 19: 4 PART 1 Antibiotic Therapy Less li
Page 20 and 21: 6 PART 1 Antibiotic Therapy Strepto
Page 22 and 23: 8 PART 1 Antibiotic Therapy Gram-po
Page 24 and 25: 10 PART 1 Antibiotic Therapy 2. Col
Page 26 and 27: 12 PART 1 Antibiotic Therapy Gram-n
Page 28 and 29: 14 PART 1 Antibiotic Therapy 2. Glu
Page 30 and 31: 16 PART 1 Antibiotic Therapy Pathog
Page 32 and 33: 18 PART 1 Antibiotic Therapy nature
Page 34 and 35: 20 PART 1 Antibiotic Therapy • Az
Page 36 and 37: 22 PART 1 Antibiotic Therapy TR’s
Page 38 and 39: 24 PART 1 Antibiotic Therapy Peak c
Page 40 and 41: 26 PART 1 Antibiotic Therapy A smal
Page 42 and 43: 28 PART 1 Antibiotic Therapy of eff
Page 44 and 45: 30 PART 1 Antibiotic Therapy be ant
Page 47 and 48: Antibiotic Pharmacodynamics 4 The t
Page 49 and 50: chapter 4 Pharmacodynamics 35 Visib
Page 51 and 52: chapter 4 Pharmacodynamics 37 Stati
Page 53: chapter 4 Pharmacodynamics 39 with
Page 56 and 57: 42 PART 1 Antibiotic Therapy cross-
Page 58 and 59: 44 PART 1 Antibiotic Therapy uses,
Page 60 and 61: 46 PART 1 Antibiotic Therapy indica
Page 63 and 64:
Beta-Lactams 6 ■■ Introduction
Page 65 and 66:
Penicillins ■■ Introduction to
Page 67 and 68:
Natural Penicillins Agents: penicil
Page 69:
chapter 6 Beta-Lactams 55 penicilli
Page 72 and 73:
58 PART 2 Antibacterial Drugs Adver
Page 74 and 75:
60 PART 2 Antibacterial Drugs Adver
Page 77 and 78:
Antipseudomonal Penicillins Agents:
Page 79 and 80:
Beta-Lactamase Inhibitor Combinatio
Page 81 and 82:
chapter 6 Beta-Lactams 67 ■■ Im
Page 83 and 84:
Cephalosporins ■■ Introduction
Page 85 and 86:
First-Generation Cephalosporins Age
Page 87 and 88:
Second-Generation Cephalosporins Ag
Page 89:
chapter 6 Beta-Lactams 75 What They
Page 92 and 93:
78 PART 2 Antibacterial Drugs assoc
Page 95 and 96:
Fourth-Generation Cephalosporins Ag
Page 97 and 98:
Fifth-Generation Cephalosporins Age
Page 99 and 100:
chapter 6 Beta-Lactams 85 Don’t F
Page 101 and 102:
88 PART 2 Antibacterial Drugs Moder
Page 104 and 105:
Monobactams Agent: aztreonam Aztreo
Page 106 and 107:
Glycopeptides 7 Agents: vancomycin,
Page 108 and 109:
chapter 7 Glycopeptides 95 was brow
Page 110 and 111:
Fluoroquinolones 8 Agents: ciproflo
Page 112 and 113:
chapter 8 Fluoroquinolones 99 Devel
Page 114 and 115:
102 PART 2 Antibacterial Drugs Spec
Page 116 and 117:
Page 118 and 119:
104 PART 2 Antibacterial Drugs by s
Page 120 and 121:
Page 122 and 123:
108 PART 2 Antibacterial Drugs syph
Page 124 and 125:
Page 126 and 127:
112 PART 2 Antibacterial Drugs Don
Page 128 and 129:
114 PART 2 Antibacterial Drugs Adve
Page 131 and 132:
Nitroimidazoles 13 Agents: metronid
Page 133:
chapter 13 Nitroimidazoles 119 •
Page 136 and 137:
Page 139 and 140:
Streptogramins 15 Agent: quinuprist
Page 141:
chapter 15 Streptogramins 127 What
Page 144 and 145:
130 PART 2 Antibacterial Drugs Adve
Page 147 and 148:
Folate Antagonists 17 Agents: trime
Page 149 and 150:
chapter 17 Folate Antagonists 135
Page 151 and 152:
Lincosamides 18 Agent: clindamycin
Page 153 and 154:
chapter 18 Lincosamides 139 these i
Page 155 and 156:
Polymyxins 19 Agents: colistin (col
Page 157 and 158:
chapter 19 Polymyxins 143 base coli
Page 159 and 160:
Fidaxomicin 20 Agent: fidaxomicin F
Page 161:
Antimycobacterial Drugs Part 3
Page 164 and 165:
150 PART 3 Antimycobacterial Drugs
Page 167 and 168:
Rifamycins 22 Agents: rifampin (aka
Page 169 and 170:
chapter 22 Rifamycins 155 it is mor
Page 171 and 172:
Isoniazid 23 Agent: isoniazid Isoni
Page 173:
chapter 23 Isoniazid 159 Don’t Fo
Page 176 and 177:
Page 178 and 179:
Page 181 and 182:
Antifungal Drugs 26 ■■ Introduc
Page 183:
chapter 26 Antifungal Drugs 169 fun
Page 186 and 187:
172 PART 4 Antifungal Drugs Spectru
Page 188 and 189:
174 PART 4 Antifungal Drugs What Th
Page 190 and 191:
176 PART 4 Antifungal Drugs Adverse
Page 193:
Azoles 29 ■■ Introduction to Az
Page 196 and 197:
Page 199 and 200:
Itraconazole Itraconazole is a broa
Page 201:
chapter 29 Azoles 187 What It’s G
Page 204 and 205:
190 PART 4 Antifungal Drugs Moderat
Page 206 and 207:
192 PART 4 Antifungal Drugs Don’t
Page 208 and 209:
Page 211 and 212:
Echinocandins 30 Agents: caspofungi
Page 213:
chapter 30 Echinocandins 199 clinic
Page 217 and 218:
Antiviral Drugs 31 ■■ Introduct
Page 219:
chapter 31 Antiviral Drugs 205 read
Page 222 and 223:
208 PART 5 Antiviral Drugs Adverse
Page 225 and 226:
Anti-Cytomegalovirus Agents 33 Agen
Page 227:
chapter 33 Anti-CMV Agents 213 Ganc
Page 230 and 231:
Page 233 and 234:
Antiretroviral Drugs 35 ■■ Intr
Page 235 and 236:
Nucleoside and Nucleotide Reverse T
Page 237 and 238:
chapter 35 Antiretroviral Drugs 223
Page 239 and 240:
Non-nucleoside Reverse Transcriptas
Page 241 and 242:
Page 243 and 244:
Protease Inhibitors Agents: atazana
Page 245 and 246:
Page 247:
Page 250 and 251:
Page 253 and 254:
Entry and Fusion Inhibitors Agents:
Page 255 and 256:
Antiviral Interferons 36 Agents: pe
Page 257 and 258:
chapter 36 Antiviral Interferons 24
Page 259 and 260:
Serine Protease Inhibitors 37 Agent
Page 261 and 262:
chapter 37 Serine Protease Inhibito
Page 263 and 264:
Ribavirin 38 Agents: ribavirin Riba
Page 265:
chapter 38 Ribavirin 251 What They
Page 268 and 269:
Page 271 and 272:
Antiparasitic Drugs 40 ■■ Intro
Page 273:
chapter 40 Antiparasitic Drugs 259
Page 276 and 277:
262 PART 6 Antiparasitic Drugs abil
Page 278 and 279:
264 PART 6 Antiparasitic Drugs worl
Page 280 and 281:
266 PART 6 Antiparasitic Drugs ■
Page 283 and 284:
Benzimidazoles 43 Agents: albendazo
Page 285:
chapter 43 Benzimidazoles 271 Don
Page 288 and 289:
274 PART 6 Antiparasitic Drugs QT p
Page 291 and 292:
Ivermectin 45 Agent: ivermectin If
Page 293 and 294:
chapter 45 Ivermectin 279 What It
Page 295 and 296:
appendix 1 Normal Human Flora 281 S
Page 297 and 298:
appendix 2 Spectrum of Activity 283
Page 299 and 300:
Page 301 and 302:
Page 303 and 304:
appendix 3 Empiric Regimens 289 Hea
Page 305 and 306:
appendix 3 Empiric Regimens 291 Int
Page 307 and 308:
Index A A. baumannii, 12-14, 67, 91
Page 309 and 310:
Index 295 Aribinosyl transferase II
Page 311 and 312:
Index 297 anaerobes and, 71, 73-75,
Page 313 and 314:
Index 299 Drug-resistant organisms,
Page 315 and 316:
Index 301 cephalosporins and, 71, 7
Page 317 and 318:
Index 303 L Lactic acidosis, 114, 2
Page 319 and 320:
Index 305 polyenes and, 171, 172, 1
Page 321 and 322:
Index 307 Plasmodium, 5, 106, 138,
Page 323 and 324:
Index 309 Seizures, 118, 154, 158,
Page 325:
Index 311 Valganciclovir, described
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