antibioticsbooks

286 appendix 2
Table A–2
Clinically Useful Spectra of Activity for Empiric Antibiotic Selection
MSSA MRSA Strep Enterococci GNR Pseudo Anaerobes* Atypicals
Doxycycline 1 1/2 1 1/2 1 11
Tigecycline 11 11 11 11 11 11 11
Clindamycin 11 1/2 11 1
Vancomycin 11 11 11 11
Azithromycin 1/2 1 1 11
Metronidazole 11
Telithromycin 1 11 1 11
Daptomycin 11 11 11 11
Linezolid 11 11 11 11
Quin/Dalf 11 11 11 11
Nitrofurantoin 1 1
Fosfomycin 1 11
TMP/SMX 11 1 1/2 1
Key: 11 5 good activity; 1 5 some activity; 1/2 5 variable activity
* Anerobes here include GI anerobes except Clostridium difficile, for which the only antibiotics with good clinical activity on this list are vancomycin and metronidazole.
†
Aminoglycosides have useful synergistic activity versus Gram-positive cocci only when paired with a cell-wall active agent (e.g., beta-lactams, vancomycin).
Abbreviations: MSSA 5 methicillin-sensitive Staphylococcus aureus; MRSA 5 methicillin-resistant Staphylococcus aureus; Strep 5 streptococci; GNR 5 aerobic
Gram-negative rods (in general, and not including P. aeruginosa); Pseudo 5 Pseudomonas aeruginosa; Imi/mero/dori5imipenem, meropenem, doripenem;
Gent/tobra5gentamicin, tobramycin; Amp/sulb 5 ampicillin/sulbactam; Pip/tazo 5 piperacillin/tazobactam; Quin/dalf 5 quinupristin/dalfopristin;
TMP/SMX 5 trimethoprim/sulfamethoxazole.