antibioticsbooks

Voriconazole
The introduction of voriconazole represented a
significant improvement in the treatment of mold
infections. It is also a broad-spectrum antifungal
like itraconazole, with good activity against
Candida species and many molds. Unlike itraconazole,
voriconazole is well absorbed and available
in both highly bioavailable oral formulations and
an IV admixture. Most importantly, voriconazole
was shown to be superior to amphotericin B deoxycholate
for invasive aspergillosis and has become
the drug of choice for that disease.
Mechanism of Action
All azoles inhibit fungal cytochrome P450 14-alpha
demethylase, inhibiting the conversion of lanosterol
into ergosterol, which is a component of the
fungal cell membrane.
Spectrum
Good: Candida albicans, Candida lusitaniae,
Candida parapsilosis, Candida tropicalis,
Candida krusei, Cryptococcus neoformans,
Aspergillus species, many other molds
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