antibioticsbooks

chapter 15 Streptogramins 127
What It’s Good For
Infections caused by MRSA or possibly E. faecium
in patients not responding to or intolerant of other
medications.
Don’t Forget!
Quinupristin/dalfopristin is not active against
Enterococcus faecalis. Between the two most common
clinical species of Enterococcus (E. faecalis and
E. faecium), E. faecalis is more common in most
hospitals, but it is less likely to be resistant to vancomycin.
For this reason, quinupristin/dalfopristin
is better employed as a definitive therapy than an
empiric one for enterococci unless you strongly suspect
E. faecium infection. Linezolid and daptomycin
do not have this issue and are generally better
therapy options.