298 Index Combivir, 221 Community-acquired pneumonia, 20, 111 Complera, 225 Coronary artery disease, 21 Corticosteroids, 271 Corynebacterium, 9 Cough, 122, 216 Cramping, 146 CRE. See Carbapenem-resistant enterobacteriaceae (CRE) Creatine kinase (CK), 130, 131 Creatine phosphokinase, 236 Cryptococcal meningitis, 174 Cryptococcus, 5, 167, 181 antimetabolites and, 175 C. neoformans, 172, 175, 181, 185, 189, 198 polyenes and, 172 Cryptosporidium, 258 Crystallization, 208 Crystalluria, 134 Crystal violet, 6 CSF. See Cerebrospinal fluid (CSF) Cutaneous larva migrans, 277, 278 CXCR4, 240 Cyclic lipopeptides, described, 129–131 Cyclodextrins, 190, 191 Cyclosporine, 19, 191, 199 CYP450 enzymes, rifamycins and, 155 Cystic fibrosis, 92, 104 Cystitis, 121, 123, 135 Cytochrome P450, 179 enzymes, 110–111 14-alpha demethylase, 185, 189, 193 system, 153 3A4, 126 Cytomegalovirus (CMV), 4, 207, 211–213 Cytopenias, 250 D DAAs. See Directacting antivirals (DAAs), for HCV infection Dalbavancin, 93 Dalfopristin, described, 125–127 Dapsone, 266 described, 133–136 Daptomycin antibacterial activity of, 38 described, 129–131 Darunavir (DRV), 26 described, 229–233 Definitive therapy defined, 18–19 examples of, 20–21 Delavirdine (DLV), described, 225–228 Depression, 226, 242, 243, 262–263 Dermatology, 106 fluoroquinolones and, 98 Diabetes, 274 foot ulcer, 21 ulcers, 68 Diarrhea, 106, 146, 186, 208, 212, 222, 231, 265 Clostridium and, 43, 138 macrolides and, 110, 111 nitroimidazoles and, 117, 118 penicillins and, 51–52, 60, 67 traveler’s, 111 Dicloxacillin, described, 57–58 Didanosine (ddI), described, 221–224 Diethyl-carbamazine, 259 Dimorphic fungi, 5, 168, 172 Diphenhydramine, 173 Directacting antivirals (DAAs), for HCV infection, 245 Distribution, antibiotic pharmacokinetics, 26–29 Disulfiram, 74, 118 Dizziness, 98, 106, 142, 226 DNA fluoroquinolones and, 97 synthesis, 175 viruses and, 204, 205 Doripenem, described, 87–89 Doxycycline, 25, 258, 264 described, 105–108 Dreams, 226, 262 Drowsiness, 226 Drug fever, 41, 49, 158, 164
Index 299 Drug-resistant organisms, 107 Drugs absorption impaired by, 26 antifungal, 167–169 antimycobacterial, 149–151 antiparasitic drugs, 257–259 antiretroviral, 219–220 antiviral, 203–205 bacteriostatic. See Bacteriostatic drugs with high bioavailability, 25 interactions, 30–31 with low bioavailability, 25 protein-bound, 28 D-test clindamycin, 139 Dysgeusia, 246 Dysglycemias, 274 Dyspnea, 122 E EBV. See Epstein-Barr virus (EBV) Echinocandins, 171, 182, 191 described, 197–199 Echinococcus, 258, 269, 270 E. coli, 4, 14, 149 aminoglycosides and, 102 antibiotic susceptibility breakpoints, 35 fluoroquinolones and, 97, 98, 99, 121 folate antagonists and, 135 nitrofurans and, 121 nitroimidazoles and, 117 penicillins and, 60, 64, 66 Efavirenz (EFV), described, 225–228 Egg albumin molecule, 7 Eikenella, 13 Electrocardiogram (ECG), 263 Elvitegravir (EVG), 235–237 EMB. See Ethambutol (EMB), described Empiric therapy, 21 defined, 17–18 examples of, 20 Emtricitabine (FTC), 225, 228, 235–237 described, 221–224 Encephalitis, 136, 207, 208 Endocarditis, 37, 72, 111, 131, 139, 156 aminoglycosides and, 61 penicillins and, 55, 58, 61 Enfuvirtide (T20), described, 239–240 Entamoeba, 118, 258 Entecavir, 253 Enterobacter, 12, 14 Enterobius vermicularis, 269 Enterococcus, 88, 98, 101, 102, 106, 110, 122, 134, 138 cephalosporins and, 71, 73, 77, 81, 83, 84 E. faecalis, 9, 10, 20, 83, 84, 126, 127 E. faecium, 9, 10, 83, 84, 93, 126, 127 glycopeptides and, 93, 94 penicillins and, 54, 57–61, 63, 64, 66 VRE (vancomycin-resistant enterococcus), 106, 113, 115, 125, 129, 130 Entry and fusion inhibitors, described, 239–240 Enzymes, drug-metabolizing, 30–31 Eosinophilic pneumonia, 130 Epstein-Barr virus (EBV), 4, 207, 212 Epzicom, 221 Ertapenem, described, 87–89 Erythema, 239–240 Erythromycin, 139 described, 109–112 ESBL. See Extended-spectrum beta-lactamases (ESBL) Escherichia coli. See E. coli Esophageal irritation, 106 E-tests, 36 Ethambutol (EMB), described, 163–164 Ethanol, 74 Etravirine (ETR), 31 described, 225–228
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Antibiotics Simplified third EDITIO
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Contents Acknowledgments Introducti
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Contents v Chapter 28: Antifungal A
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Acknowledgments Our thanks go to th
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x Introduction ■■ How to Use Th
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New to the Third Edition The Third
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The Wonderful World of Microbiology
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chapter 1 Microbiology 5 More like
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chapter 1 Microbiology 7 Influenza
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chapter 1 Microbiology 11 Gram-nega
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Adverse Consequences of Antibiotic
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Fluconazole The introduction of flu
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