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chapter 29 Azoles 195
inhibitors lower absorption, and administering
with a soda is not enough to overcome this
factor. Posaconazole drug concentrations are
not routinely tested in many labs, but tests are
becoming available and may be a way to ensure
that patients are absorbing enough of the drug
for it to be effective.
What It’s Good For
Posaconazole is most commonly used as prophylaxis
against fungal infections in susceptible hosts,
but it can also be used in zygomycosis, oropharyngeal
candidiasis, and fungal infections refractory to
other agents.
Don’t Forget!
Have your patients take posaconazole with meals
to ensure adequate absorption. This is not always
possible with neutropenic patients with mucositis.