antibioticsbooks

Atovaquone
42
Agents: atovaquone, atovaquone/proguanil
Atovaquone is an antiparasitic agent with activity
against several important protozoans. Its activity
against the malaria parasite is enhanced when
given in combination with the drug proguanil
(this co-formulated tablet is known as Malarone).
Atovaquone tends to be better tolerated than comparator
drugs but is limited by the lack of an IV
formulation (for severe disease), high cost, and
somewhat lower efficacy (for Pneumocystis disease).
Mechanism of Action
Atovaquone appears to interfere with electron
transport in the parasitic mitochondria.
Spectrum
Like-a-parasite-but-technically-a-fungus: Pneumocystis
jirovecii
Protozoa: Plasmodium species, Toxoplasma gondii,
Babesia species
Adverse Effects
Both atovaquone and atovaquone/proguanil are
very well tolerated. The most common adverse
effects are gastrointestinal (nausea/vomiting, diarrhea,
abdominal pain).