antibioticsbooks

Posaconazole
Posaconazole is the newest extended-spectrum
azole. It is an analog of itraconazole that is substantially
more active against many fungi. Currently, it
is indicated only for the prophylaxis of fungal infections
in neutropenic patients and the treatment
of oropharyngeal candidiasis. It is unique among
the azoles in that it has good activity against the
Zygomycetes, a difficult-to-treat class of molds
that most antifungals (voriconazole included) do
not treat.
Mechanism of Action
All azoles inhibit fungal cytochrome P450 14-alpha
demethylase, inhibiting the conversion of lanosterol
into ergosterol, which is a component of the
fungal cell membrane.
Spectrum
Good: Candida albicans, Candida lusitaniae,
Candida parapsilosis, Candida tropicalis, Candida
krusei, Aspergillus species, Zygomycetes,
many other molds, dimorphic fungi
Moderate: Fusarium species, Candida glabrata
Though posaconazole is active against these
organisms, clinical data are lacking for many of
them.
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