immunology of infectious and parasitic diseases - XXXVII Congress ...

Evaluation of cytokine and chemokine expression in situ was determined by
immunohistochemistry.
In situ evaluation showed similar production of IFNg, TNFa, IL-10, transforming
growth factor-beta (TGFb), chemokine (C-C motif) lig-and 2 (CCL2), CCL3,
CCL11 and chemokine (C-X-C motif) ligand 10 (CXCL10) in papular and
ulcerative lesions from DL as well as in ulcerated lesions from CL. Serum levels
of CXCL9, a chemokine that attracts T-cells, was higher in serum from DL than
from CL.
Conclusion:
These data indicate that a decrease in the type 1 immune response in
peripheral blood of DL patients is due to attraction of Leishmania antigenactivated
T-cells to the multiple cutaneous lesions. This may account for the
absence or few parasites in the lesions and for the development of ulcers
similar to those observed in CL.
Financial support: Instituto Nacional de Ciência e Tecnologia de Doenças
Tropicais – Conselho Nacional de Desenvolvimento Científico e Tecnológico
(INCT-DT/CNPq).