immunology of infectious and parasitic diseases - XXXVII Congress ...

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animals in groups are required to assess whether the increase in parasite density in the liver is associated with increased production of TGF-β. Financial support: FAPESP (2009/15736-7). Key words: Immunohistochemistry, Leishmania chagasi, liver, cytokines, dog.
DIFFERENT LEVELS OF NKT AND NK CELLS IN PATIENTS WITH LEPROSY CAMILA FERNANDES (PG) (1) ; FABIOLA FERNANDES HEREDIA (GRAD) (2) ; PAULA BRITO E CABRAL (1) ; MÁRCIA BRASIL (1) ; LILIA MARIA CARNEIRO CÂMARA (1) . (1) Universidade Federal do Ceará (2) Universidade Estadual do Ceará Introduction: Leprosy is caused by Mycobacterium leprae and is characterized by skin lesions with abnormal sensitivity and neuritis, representing an important an important public health problem worldwide. There is a spectrum variable manifestations depending on the pattern of immune response, with paucibacillary (PB) form characterized by Th1 and multibacillary (MB) form by the Th2 response (Lancet Infect Dis. 11:464-70, 2011). NK cells are important in protection against M. leprae, being responsible for the initial response as well as the production of Th1 and Th2 cytokines (Clin Exp Immunol. 135:105-113, 2004). Natural killer T lymphocytes (NKT) have effector and regulatory capacity and can recognize glycolipid antigens presented via CD1d, which can be expressed in Schwann cells, providing a link between innate and adaptive immunity in M. leprae infection (Clin Immunol. 127 : 214:224, 2008). Despite this evidence, the role of these cells in leprosy is not clearly elucidated. This study we investigated the frequency of NKT cells and NK cells in patients with leprosy without treatment. Methods and results: We studied 6 patients (2 PB and 4MB) aged 6 to 16 years (median = 11.5), and an adult patient (MB) and a healthy adult. 2.5 x10 5 PBMC were labeled with anti-CD3-APC (BioLegend), anti-CD16FITC (e-Biosciences), anti-CD56PE (e-Biosciences) and anti- CD8PerCp (e-Biosciences). The reading was held on FACSCalibur, purchased 350 thousand events in the lymphocyte gate. In assessing the positivity within the gated CD8 lymphocytes, all patients had more CD8 + (mean = 35.74%, var. 24.32 to 46.89%) than the control (23.8%), correlating positively with age (Spearman = 0.7857, p = 0.0480). The average percentage (0.54%; var. 0.12 to 1.02) of CD3 + CD16 + CD56 + (NKT) was lower than the control (1.26%). 71.4% of patients showed mean percentage of CD3 - CD16 + CD56 + (NK) (8.21%; var. 2.98 to 12.68) greater than control (1.98%). The adult patient, MB form, was the only individual whose percentage of CD3 + CD8 + CD16 + CD56 - was greater than CD3 + CD16 + CD56 + CD8 + . Conclusion: We observed a lower number of NKT and an increase of NK cells in patients, which may suggest an important role of these cells in leprosy, despite the limited size of the sample. A larger sample of patients and controls should be considered in future work.
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IMMUNOLOGY OF INFECTIOUS AND PARASI
Page 3 and 4: profiles appear to be dependent on
Page 5 and 6: INVOLVEMENT OF TNF RECEPTORS IN APO
Page 7 and 8: Effects of bioactive Cryptococcus n
Page 9 and 10: DCs expressing Indoleamine 2,3-diox
Page 11 and 12: DETECTION OF GITR ON PATIENT CERVIX
Page 13 and 14: DETECTION OF GITR AND IL-10 ON CERV
Page 15 and 16: VACCINATION WITH SM10.3 ANTIGEN, A
Page 17 and 18: Financial support: FAPESP, CAPES an
Page 19 and 20: clearance that follows Sylvio X10/4
Page 21 and 22: EhMSP-1 - AN ENTAMOEBA HISTOLYTICA
Page 23 and 24: THERAPY WITH SCFV TRANSFECTED-DENDR
Page 25 and 26: etween the groups. The results show
Page 27 and 28: Financial support: FIOCRUZ, CNPq.
Page 29 and 30: elease of NETs from human neutrophi
Page 31 and 32: ROLE OF CD18 IN ACTIVATION OF M1 MA
Page 33 and 34: IDENTIFICATION, PURIFICATION AND CH
Page 35 and 36: with hemin showed higher levels of
Page 37 and 38: SEPTIC ARTHRITIS TRIGGERED BY S. au
Page 39 and 40: eing higher levels induced by a vir
Page 41 and 42: parasite load skin. The TGF-β was
Page 43 and 44: cultures, both treatments decreased
Page 45 and 46: observed a tendency to lower parasi
Page 47 and 48: SERUM COMPONENTS AND MONONUCLEAR CE
Page 49 and 50: VIABILITY OF LEISHMANIA (L.) CHAGAS
Page 51 and 52: EVALUATION OF THE INTERFERENCE OF S
Page 53: IMMUNODETECTION OF THE TGF- β IN L
Page 57 and 58: Funding: CNPQ; FAPESPA; SESPA; UFPA
Page 59 and 60: saliva that exacerbated leishmania
Page 61 and 62: BACTERIAL FILAMENTATION: SUPER-RESI
Page 63 and 64: IMMUNOLOGICAL PARAMETERS ASSOCIATED
Page 65 and 66: supernatant. BMDC stimulation with
Page 67 and 68: such as number of eosinophils, prot
Page 69 and 70: EVALUATION OF THE PRODUCTION OF TNF
Page 71 and 72: Critical motifs of the Anaplasma ma
Page 73 and 74: SCHISTOSOMA SPP ANTIGENS IMPAIR THE
Page 75 and 76: DOWN-REGULATION OF IFN-g RECEPTOR A
Page 77 and 78: MONOCYTES SUBSETS IN SCHISTOSOMIASI
Page 79 and 80: THE IN VITRO ANALYSIS OF iNOS-KO MO
Page 81 and 82: CCR7 IS CRITICAL FOR RESISTANCE AGA
Page 83 and 84: EVALUATION OF THE IMMUNE RESPONSE A
Page 85 and 86: our data suggest that monocyte secr
Page 87 and 88: DIVERGENT OUTCOMES OF THE INTERACTI
Page 89 and 90: they can deactivate immune effector
Page 91 and 92: Conclusions: We observed a signific
Page 93 and 94: TLR2 AND TLR4 EXPRESSION AND NUTRIT
Page 95 and 96: DEVELOPMENT OF MURINE PLACENTAL MAL
Page 97 and 98: INDUCTION OF TH17 LYMPHOCYTES CONTR
Page 99 and 100: Leishmania amazonensis INCREASES EC
Page 101 and 102: TYPE II GRANULOMA INDUCED BY SCHIST
Page 103 and 104: The Role of Eosinophils in Aspergil
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compared to baseline (p
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disordered loop and NcSAG2A present
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Conclusion: We demonstrate the exis
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WT. By contrast, uninfected AhR -/-
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in the synthesis of proinflammatory
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PRODUCTION AND EVALUATION OF CHICKE
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allow a conclusion about the differ
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contributes to parasite control and
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Financial support: FAPESP, CNPq, an
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MILTEFOSINE EXERTS ITS LEISHMANICID
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IMMUNOMODULATORY ACTIVITIES OF Β-G
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REGULATION OF IMMUNE RESPONSE AGAIN
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THE ROLE OF REACTIVE OXIGEN SPECIES
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INNATE AND ADAPTIVE IMMUNE REPONSE
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KINETIC OF THE SPECIFIC HUMMORAL IM
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PURINERGIC RECEPTOR P2Y12 ACTIVATIO
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Evaluation of cytokine and chemokin
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Financial support: This research wa
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COMPARISON OF VIRULENCE AND IMMUNE
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THE IMPACT OF TUBERCULOSIS IN THE I
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GALACTOMANNAN ANTIGENEMIA SCREENING
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NATURAL ISOTYPIC RESPONSE AGAINST P
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Characterization of costimulatory m
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P2X7 RECEPTOR ACTIVATION IS REQUIRE
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CASPASE-1 AND NLRP3 CONTRIBUTE TO T
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circulating Treg cells expressing C
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PBMC, none of the treatments alter
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CHARACTERIZATION OF MONOCYTE SUBSET
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EFFECT OF OUABAIN IN MACROPHAGES IN
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OspC1 AND OspF: VIRULENCE FACTORS I
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Conclusion: Taken together, these r
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FIB produced higher proportion of f
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MØ phenotype M2, resulting in decr
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Financial support FAPESP, CAPES, CN
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ALTERATION IN THE DISTRIBUTION OF P
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BENEFICIAL EFFECTS OF PENTOXIFYLLIN
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MODULATION OF IMMUNE RESPONSE AND C
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FAS/FASL AND TRAIL CAUSE APOPTOSIS
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actin were more frequently detected
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NEUTROPHILS AND MACROPHAGES ARE INV
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EXPLORING THE INFLAMMATORY ROLE OF
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CERVICAL LEVELS OF INTERLEUKIN-1 BE
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Title: IDENTIFICATION BY PHAGE DISP
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PROFILE OF PRO- AND ANTI-INFLAMMATO
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IMMUNOMODULATORY MECHANISMS OF SOLU
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EVALUATION OF THE TH1, TH2 AND TH17
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production, as the blockade of PD-L
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CHARACTERIZATION OF POLYMORPHISM TN
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seems to be dependent on M. leprae
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7 with tendency to normalization on
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CHARACTERIZATION OF THE CONSERVATIO
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ASC INFLAMMASOME IS NECESSARY TO AC
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CASPASE-1 IS REQUIRED TO CONTROL OF
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The role of CD4 + T lymphocytes dur
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CRITICAL ROLE OF MYD88 EXPRESSION I
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on ROS, cathepsin B and Syk kinase
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Financial Support: FAPESP and CNPq.
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80% in symptomatic group; 45% in as
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of cells undergoing apoptosis in DT
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Financial support: FAPESP/LIM-56/HC
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identify the active components and
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EVALUATION OF HUMORAL AND CELULLAR
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Financial support: CNPq-PIBIC, FAPE
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addition, significant expression of
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THE ROLE OF K + TRANSPORTERS IN THE
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Conclusion: In this study, we estab
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Heme activates oxidative mechanisms
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ROLE OF ADENOSINE AND PROSTAGLANDIN
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Taken together, our results indicat
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Conclusion: Our findings suggest th
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Financial support: CNPq, CAPES, IOC
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number of circulating parasites in
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CRITICAL ROLE OF IL-6 IN REGULATORY
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PPAR-α AGONIST GEMFIBROZIL DECREAS
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Cutaneous Leishmaniasis in Amazonas
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CYTOTOXICITY IN IMMUNOPATHOGENESIS
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ROS production and TLR2 and 4 expre
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ROLE OF IL-4 IN THE INTESTINAL INFL
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In vitro CULTURE SYSTEM FOR Plasmod
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interactions, Tandem Affinity Purif
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in the course of human infection wi
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findings suggest that IL-17 and IL-
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23 contribute to immunological cont
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not produced during infection by C.
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Conclusion: The production of cytok
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CONCLUSION: It is likely, in this p
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expression in CCC myocardium was 64
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that mononuclear cells derived from
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Conclusion: Altogether, our data sh
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PARACOCCIDIOIDES BRASILIENSIS INHIB
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CANINE VISCERAL LEISHMANIASIS AND S
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IMMUNOMODULATORY EFFECTS OF BIOTHER
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Leishmania EFFECT ON HEME CYTOTOXIC
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ROLE OF STRONGYLOIDES VENEZUELENSIS
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TREATMENT WITH Harpagophytum procum
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