immunology of infectious and parasitic diseases - XXXVII Congress ...

predominantly IgG1 and R2-induced antibodies were predominantly of cytophilic
subclasses. S4 and P11 epitopes were identified as immunodominant B-cell
epitopes. These results are distinguishable from a study conducted in clinically
immune Liberian adults, in whom the most frequently recognized B-cell epitopes
of GLURP were P3 and P4. However, in RB group, P3 and S3 epitopes induced
higher levels of cytophilic antibodies, effective in ADCI, like clinically immune
Liberian adults. Conclusions: GLURP is immunogenic in natural conditions of
exposure and the seropositivity to GLURP increases with exposure. Also,
GLURP is able to induce cytophilic antibodies that can participate of protective
acquisition immunity. In conclusion, our results highlight the importance of
GLURP like a malaria vaccine candidate.