immunology of infectious and parasitic diseases - XXXVII Congress ...

expressing monocytes was significantly lower in peripheral blood from CL
patients when compared to healthy controls, indicating that CCR2 expressing
cells might migrate to the lesion site. Analysis of biopsies from CL patients
showed that the predominant population of monocyte found in lesions of these
individuals was the non-classical one.
Conclusion. Altogether, our data show differences among monocyte subsets in
CL. While classical and intermediate monocytes produce more TNF, nonclassical
ones are more frequent in lesions of these patients. The identifation of
cells that contribute to the immunopatology observed in CL will help to develop
new forms of immunotherapy to this disease.
Financial Support: CNPq, CAPES and NIH (AI030639 -TMRC- and AI088650
-ICIDR).