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Conclusion: This same clone showed greater sensitivity to recognize antibodies from patients with active tuberculosis and individuals PPD+, and promising for immunological diagnosis of tuberculosis. The phage display methodology was presented as an important tool in the development of a diagnostic platform, allowing the characterization of antigenic mimotopes to differentiate active tuberculosis infection. Financial support: CAPES; CNPq; FAPEMIG; UFU.
PROFILE OF PRO- AND ANTI-INFLAMMATORY CYTOKINES IN PATIENTS WITH MALARIA ASSISTED AT THE INSTITUTO DE MEDICINA TROPICAL OF COARI-AM ALLYSON GUIMARÃES DA COSTA (PG)(1,2); JOÃO PAULO DINIZ PIMENTEL (PG)(2,3); NADJA PINTO GARCIA (PG)(2); ANDRÉA MONTEIRO TARRAGÔ (PG)(1,2); LUCYANE BASTOS TAVARES DA SILVA (IC)(2); JÉSSICA PEREIRA MARQUES (IC)(2); WALTER LUIZ LIMA NEVES (PG)(1,2); ADRIANA MALHEIRO (PG)(1,2). (1). Universidade Federal do Amazonas; (2). Fundação de Hematologia e Hemoterapia do Amazonas; (3). Instituto Leônidas e Maria Deane/Fiocruz Amazônia. Introduction: Malaria is a major parasitic disease of tropical regions. Three species are associated with this infection in Brazil P. vivax, P. falciparum and P. malariae. The immune response has many defense mechanisms which result in the inflammation process and the individual resistance to the pathogen. In general, the clinical manifestations are dependent on the concentrations of pro and anti-inflammatory cytokines, which contribute to the immunopathology of the disease. The aim of this study was to quantify the inflammatory and antiinflammatory cytokines in individuals with malaria treated at the Instituto de Medicina Tropical of Coari-AM. Methods and Results: Serum levels of cytokines (IL-2, IL-4, IL-6, IL-10, TNF-, IFN- and IL-17) were measured in the plasma of 50 individuals (25 malaria patients infected by Plasmodium vivax and 25 uninfected - control group) using the technique of CBA (Citometry Bead Array) using the kit TH1, TH2 and TH17 (BD Biosciences). The analyzes of serum concentrations were performed with the software FCAP-Array (v3.0) and the results were analyzed using the statistical software GraphPad Prism ® (v5.0), using the nonparametric Mann-Whitney test. The concentrations of IL-2, IL-4 and TNF- were lower among patients with malaria compared with control subjects (p=0.1252, p=0.4707 and p=0.0456, respectively). While serum levels of IL-6, IL-10, IL-17 and IFN- were significantly higher among the infected group compared to uninfected individuals (p
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IMMUNOLOGY OF INFECTIOUS AND PARASI
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profiles appear to be dependent on
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INVOLVEMENT OF TNF RECEPTORS IN APO
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Effects of bioactive Cryptococcus n
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DCs expressing Indoleamine 2,3-diox
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DETECTION OF GITR ON PATIENT CERVIX
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DETECTION OF GITR AND IL-10 ON CERV
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VACCINATION WITH SM10.3 ANTIGEN, A
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Financial support: FAPESP, CAPES an
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clearance that follows Sylvio X10/4
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EhMSP-1 - AN ENTAMOEBA HISTOLYTICA
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THERAPY WITH SCFV TRANSFECTED-DENDR
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etween the groups. The results show
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Financial support: FIOCRUZ, CNPq.
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elease of NETs from human neutrophi
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ROLE OF CD18 IN ACTIVATION OF M1 MA
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IDENTIFICATION, PURIFICATION AND CH
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with hemin showed higher levels of
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SEPTIC ARTHRITIS TRIGGERED BY S. au
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eing higher levels induced by a vir
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parasite load skin. The TGF-β was
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cultures, both treatments decreased
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observed a tendency to lower parasi
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SERUM COMPONENTS AND MONONUCLEAR CE
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VIABILITY OF LEISHMANIA (L.) CHAGAS
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EVALUATION OF THE INTERFERENCE OF S
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IMMUNODETECTION OF THE TGF- β IN L
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DIFFERENT LEVELS OF NKT AND NK CELL
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Funding: CNPQ; FAPESPA; SESPA; UFPA
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saliva that exacerbated leishmania
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BACTERIAL FILAMENTATION: SUPER-RESI
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IMMUNOLOGICAL PARAMETERS ASSOCIATED
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supernatant. BMDC stimulation with
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such as number of eosinophils, prot
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EVALUATION OF THE PRODUCTION OF TNF
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Critical motifs of the Anaplasma ma
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SCHISTOSOMA SPP ANTIGENS IMPAIR THE
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DOWN-REGULATION OF IFN-g RECEPTOR A
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MONOCYTES SUBSETS IN SCHISTOSOMIASI
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THE IN VITRO ANALYSIS OF iNOS-KO MO
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CCR7 IS CRITICAL FOR RESISTANCE AGA
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EVALUATION OF THE IMMUNE RESPONSE A
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our data suggest that monocyte secr
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DIVERGENT OUTCOMES OF THE INTERACTI
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they can deactivate immune effector
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Conclusions: We observed a signific
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TLR2 AND TLR4 EXPRESSION AND NUTRIT
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DEVELOPMENT OF MURINE PLACENTAL MAL
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INDUCTION OF TH17 LYMPHOCYTES CONTR
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Leishmania amazonensis INCREASES EC
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TYPE II GRANULOMA INDUCED BY SCHIST
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The Role of Eosinophils in Aspergil
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compared to baseline (p
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disordered loop and NcSAG2A present
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Conclusion: We demonstrate the exis
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WT. By contrast, uninfected AhR -/-
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in the synthesis of proinflammatory
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PRODUCTION AND EVALUATION OF CHICKE
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allow a conclusion about the differ
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contributes to parasite control and
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Financial support: FAPESP, CNPq, an
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MILTEFOSINE EXERTS ITS LEISHMANICID
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IMMUNOMODULATORY ACTIVITIES OF Β-G
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REGULATION OF IMMUNE RESPONSE AGAIN
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THE ROLE OF REACTIVE OXIGEN SPECIES
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INNATE AND ADAPTIVE IMMUNE REPONSE
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KINETIC OF THE SPECIFIC HUMMORAL IM
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PURINERGIC RECEPTOR P2Y12 ACTIVATIO
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Evaluation of cytokine and chemokin
Page 139 and 140: Financial support: This research wa
Page 141 and 142: COMPARISON OF VIRULENCE AND IMMUNE
Page 143 and 144: THE IMPACT OF TUBERCULOSIS IN THE I
Page 145 and 146: GALACTOMANNAN ANTIGENEMIA SCREENING
Page 147 and 148: NATURAL ISOTYPIC RESPONSE AGAINST P
Page 149 and 150: Characterization of costimulatory m
Page 151 and 152: P2X7 RECEPTOR ACTIVATION IS REQUIRE
Page 153 and 154: CASPASE-1 AND NLRP3 CONTRIBUTE TO T
Page 155 and 156: circulating Treg cells expressing C
Page 157 and 158: PBMC, none of the treatments alter
Page 159 and 160: CHARACTERIZATION OF MONOCYTE SUBSET
Page 161 and 162: EFFECT OF OUABAIN IN MACROPHAGES IN
Page 163 and 164: OspC1 AND OspF: VIRULENCE FACTORS I
Page 165 and 166: Conclusion: Taken together, these r
Page 167 and 168: FIB produced higher proportion of f
Page 169 and 170: MØ phenotype M2, resulting in decr
Page 171 and 172: Financial support FAPESP, CAPES, CN
Page 173 and 174: ALTERATION IN THE DISTRIBUTION OF P
Page 175 and 176: BENEFICIAL EFFECTS OF PENTOXIFYLLIN
Page 177 and 178: MODULATION OF IMMUNE RESPONSE AND C
Page 179 and 180: FAS/FASL AND TRAIL CAUSE APOPTOSIS
Page 181 and 182: actin were more frequently detected
Page 183 and 184: NEUTROPHILS AND MACROPHAGES ARE INV
Page 185 and 186: EXPLORING THE INFLAMMATORY ROLE OF
Page 187 and 188: CERVICAL LEVELS OF INTERLEUKIN-1 BE
Page 189: Title: IDENTIFICATION BY PHAGE DISP
Page 193 and 194: IMMUNOMODULATORY MECHANISMS OF SOLU
Page 195 and 196: EVALUATION OF THE TH1, TH2 AND TH17
Page 197 and 198: production, as the blockade of PD-L
Page 199 and 200: CHARACTERIZATION OF POLYMORPHISM TN
Page 201 and 202: seems to be dependent on M. leprae
Page 203 and 204: 7 with tendency to normalization on
Page 205 and 206: CHARACTERIZATION OF THE CONSERVATIO
Page 207 and 208: ASC INFLAMMASOME IS NECESSARY TO AC
Page 209 and 210: CASPASE-1 IS REQUIRED TO CONTROL OF
Page 211 and 212: The role of CD4 + T lymphocytes dur
Page 213 and 214: CRITICAL ROLE OF MYD88 EXPRESSION I
Page 215 and 216: on ROS, cathepsin B and Syk kinase
Page 217 and 218: Financial Support: FAPESP and CNPq.
Page 219 and 220: 80% in symptomatic group; 45% in as
Page 221 and 222: of cells undergoing apoptosis in DT
Page 223 and 224: Financial support: FAPESP/LIM-56/HC
Page 225 and 226: identify the active components and
Page 227 and 228: EVALUATION OF HUMORAL AND CELULLAR
Page 229 and 230: Financial support: CNPq-PIBIC, FAPE
Page 231 and 232: addition, significant expression of
Page 233 and 234: THE ROLE OF K + TRANSPORTERS IN THE
Page 235 and 236: Conclusion: In this study, we estab
Page 237 and 238: Heme activates oxidative mechanisms
Page 239 and 240: ROLE OF ADENOSINE AND PROSTAGLANDIN
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Taken together, our results indicat
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Conclusion: Our findings suggest th
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Financial support: CNPq, CAPES, IOC
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number of circulating parasites in
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CRITICAL ROLE OF IL-6 IN REGULATORY
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PPAR-α AGONIST GEMFIBROZIL DECREAS
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Cutaneous Leishmaniasis in Amazonas
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CYTOTOXICITY IN IMMUNOPATHOGENESIS
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ROS production and TLR2 and 4 expre
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ROLE OF IL-4 IN THE INTESTINAL INFL
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In vitro CULTURE SYSTEM FOR Plasmod
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interactions, Tandem Affinity Purif
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in the course of human infection wi
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findings suggest that IL-17 and IL-
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23 contribute to immunological cont
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not produced during infection by C.
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Conclusion: The production of cytok
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CONCLUSION: It is likely, in this p
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expression in CCC myocardium was 64
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that mononuclear cells derived from
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Conclusion: Altogether, our data sh
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PARACOCCIDIOIDES BRASILIENSIS INHIB
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CANINE VISCERAL LEISHMANIASIS AND S
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IMMUNOMODULATORY EFFECTS OF BIOTHER
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Leishmania EFFECT ON HEME CYTOTOXIC
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ROLE OF STRONGYLOIDES VENEZUELENSIS
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TREATMENT WITH Harpagophytum procum
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