immunology of infectious and parasitic diseases - XXXVII Congress ...

EVALUATION OF THE IMMUNOLOGICAL AND PARASITOLOGICAL
EFFECTS OF CAESALPINIA PYRAMIDALIS IN GOATS NATURALLY
INFECTED BY HAEMONCHUS CONTORTUS
GEYANNA DOLORES LOPES NUNES 1 ; FAROUK ZACHARIAS 2 ; JORGE
MAURÍCIO DAVID 3 ; JUCENI PEREIRA DAVID 4 ; SÍLVIA CAROLINE OLIVEIRA
SANTOS 4 ; MÁRCIA CRISTINA AQUINO TEIXEIRA 4 ; FERNANDA
WASHINGTON DE MENDONÇA LIMA 4 .
1 Escola de Medicina Veterinária e Zootecnia-UFBA, Brasil; 2 Empresa Bahiana
de Desenvolvimento Agrícola-EBDA, Brasil; 3 Instituto de Química-UFBA, Brasil;
4 Faculdade de Farmácia-UFBA, Brasil.
Introduction: Helminthiasis leads to enormous economic losses in small
ruminant production. Development resistance to the most commercially
available anthelmintics awakened the interest in phytotherapy as an alternative
treatment (Rev. Bras. Pl. Med. 7:97-106, 2005). Caesalpinia pyramidalis has its
leaves used in traditional medicine to combat fever, diarrhea, gastritis (J.
Ethnopharmacol. 131:326–342, 2010). The aim of this study was to evaluate
the possible effect immunomodulator and parasiticide of C. pyramidalis
aqueous extract in the control of Haemonchus contortus in naturally infected
goats.
Methods and Results: A total of 60 mixed breed goats were equally divided
into six groups: the first group (G1) received only water, the second group (G2)
was treated with doramectin, an anthelmintic drug, and the remaining groups
(G3 to G6) received C. pyramidalis extract orally. The goats were naturally
infected with helminths, predominantly Haemonchus contortus (81.6%). Before
initiation of treatments, and at 30, 60 and 90 days, it was verified in each animal
the number of eggs per gram of feces (EPG) by the McMaster technique, and
the levels of IgG anti-H. contortus by indirect ELISA. The mean values of each
group were compared by ANOVA followed by Tukey post-test (P