immunology of infectious and parasitic diseases - XXXVII Congress ...

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THE INVOLVEMENT OF HEME OXYGENASE-1 (HO-1) IN THE CONTROL OF Toxoplasma gondii REPLICATION IN C57BL/6 MICE ESTER CRISTINA BORGES ARAUJO 1 ; BELLISA DE FREITAS BARBOSA 2 ; PAULO VICTOR CZARNEWSKI BARENCO 1 ; LUCIANA ALVES DE SOUSA 1 ; LOYANE BERTAGNOLLI COUTINHO 1 ; ELOISA AMÁLIA VIEIRA FERRO 2 ; DEISE APARECIDA OLIVEIRA SILVA 3 ; CRISTIANE MARIA MILANEZI 4 ; GIULIANO BONFÁ 4 ; JOÃO SANTANA SILVA 4 ; JAIR PEREIRA DA CUNHA- JÚNIOR 3 ; NEIDE MARIA SILVA 1 1 Laboratory of Immunopathology, Institute of Biomedical Sciences, Federal University of Uberlândia, 2 Laboratory of Histology and Embryology, Institute of Biomedical Sciences, Federal University of Uberlândia, 3 Laboratory of Immunoparasitology, Institute of Biomedical Sciences, Federal University of Uberlândia, 4 Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo. Introduction: Toxoplasma gondii is an apicomplexan parasite characterized to induce type 1 immune response in infected hosts and the disease occurs mainly in immunocompromised individuals. Heme oxygenase-1 (HO-1) is the enzyme that catabolizes free heme that induces an intense inflammatory response. Furthermore, the expression of HO-1 is induced by different stimuli, triggering an anti-inflammatory response during biological stress. Additionally, it was previously verified that HO-1 are able to induce the indoleamine 2,3dioxygenase (IDO), an enzyme known to be involved in the parasite control. Methods and Results: To verify the role of HO-1 during in vivo infection, BALB/c and C57BL/6 mice were infected with ME49 strain of T. gondii and treated during 12 days with zinc protoporphyrin IX (ZnPPIX) or hemin, which inhibit or induce HO-1 expression, respectively. The results showed that C57BL6 and BALB/c mice treated with ZnPPIX showed higher tissue parasitism in the lung (BALB/c: 3.71 ± 2.36; C57BL/6: 35.00 ± 19.8), whereas treatment with hemin decreased the replication of the parasite in this organ (BALB/c: 0.35 ± 0.43; C57BL/6: 1.82 ± 2.37) and in the small intestine of C57BL/6 infected mice (1.25 ± 0.93). It was observed that T. gondii infection induced high levels of HO-1 mRNA in the lung of infected mice. Furthermore, C57BL/6 mice treated
with hemin showed higher levels of IDO mRNA (10.34 ± 2.46) and protein expression (2.71 ± 1.17) than non-infected mice (1.33 ± 1.27; 1.02 ± 0.93) in the lung. Conclusion: In conclusion, our data suggest that the control of the parasite in the lung of infected mice is at least in part dependent of HO-1 through IDO induction, mainly in C57BL/6 mice. In the small intestine elevated HO-1 expression contributes to the control of T. gondii replication, but in an IDO independent manner. Financial support: CAPES, CNPq, FAPEMIG
Page 1 and 2: IMMUNOLOGY OF INFECTIOUS AND PARASI
Page 3 and 4: profiles appear to be dependent on
Page 5 and 6: INVOLVEMENT OF TNF RECEPTORS IN APO
Page 7 and 8: Effects of bioactive Cryptococcus n
Page 9 and 10: DCs expressing Indoleamine 2,3-diox
Page 11 and 12: DETECTION OF GITR ON PATIENT CERVIX
Page 13 and 14: DETECTION OF GITR AND IL-10 ON CERV
Page 15 and 16: VACCINATION WITH SM10.3 ANTIGEN, A
Page 17 and 18: Financial support: FAPESP, CAPES an
Page 19 and 20: clearance that follows Sylvio X10/4
Page 21 and 22: EhMSP-1 - AN ENTAMOEBA HISTOLYTICA
Page 23 and 24: THERAPY WITH SCFV TRANSFECTED-DENDR
Page 25 and 26: etween the groups. The results show
Page 27 and 28: Financial support: FIOCRUZ, CNPq.
Page 29 and 30: elease of NETs from human neutrophi
Page 31 and 32: ROLE OF CD18 IN ACTIVATION OF M1 MA
Page 33: IDENTIFICATION, PURIFICATION AND CH
Page 37 and 38: SEPTIC ARTHRITIS TRIGGERED BY S. au
Page 39 and 40: eing higher levels induced by a vir
Page 41 and 42: parasite load skin. The TGF-β was
Page 43 and 44: cultures, both treatments decreased
Page 45 and 46: observed a tendency to lower parasi
Page 47 and 48: SERUM COMPONENTS AND MONONUCLEAR CE
Page 49 and 50: VIABILITY OF LEISHMANIA (L.) CHAGAS
Page 51 and 52: EVALUATION OF THE INTERFERENCE OF S
Page 53 and 54: IMMUNODETECTION OF THE TGF- β IN L
Page 55 and 56: DIFFERENT LEVELS OF NKT AND NK CELL
Page 57 and 58: Funding: CNPQ; FAPESPA; SESPA; UFPA
Page 59 and 60: saliva that exacerbated leishmania
Page 61 and 62: BACTERIAL FILAMENTATION: SUPER-RESI
Page 63 and 64: IMMUNOLOGICAL PARAMETERS ASSOCIATED
Page 65 and 66: supernatant. BMDC stimulation with
Page 67 and 68: such as number of eosinophils, prot
Page 69 and 70: EVALUATION OF THE PRODUCTION OF TNF
Page 71 and 72: Critical motifs of the Anaplasma ma
Page 73 and 74: SCHISTOSOMA SPP ANTIGENS IMPAIR THE
Page 75 and 76: DOWN-REGULATION OF IFN-g RECEPTOR A
Page 77 and 78: MONOCYTES SUBSETS IN SCHISTOSOMIASI
Page 79 and 80: THE IN VITRO ANALYSIS OF iNOS-KO MO
Page 81 and 82: CCR7 IS CRITICAL FOR RESISTANCE AGA
Page 83 and 84: EVALUATION OF THE IMMUNE RESPONSE A
Page 85 and 86:
our data suggest that monocyte secr
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DIVERGENT OUTCOMES OF THE INTERACTI
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they can deactivate immune effector
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Conclusions: We observed a signific
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TLR2 AND TLR4 EXPRESSION AND NUTRIT
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DEVELOPMENT OF MURINE PLACENTAL MAL
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INDUCTION OF TH17 LYMPHOCYTES CONTR
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Leishmania amazonensis INCREASES EC
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TYPE II GRANULOMA INDUCED BY SCHIST
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The Role of Eosinophils in Aspergil
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compared to baseline (p
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disordered loop and NcSAG2A present
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Conclusion: We demonstrate the exis
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WT. By contrast, uninfected AhR -/-
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in the synthesis of proinflammatory
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PRODUCTION AND EVALUATION OF CHICKE
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allow a conclusion about the differ
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contributes to parasite control and
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Financial support: FAPESP, CNPq, an
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MILTEFOSINE EXERTS ITS LEISHMANICID
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IMMUNOMODULATORY ACTIVITIES OF Β-G
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REGULATION OF IMMUNE RESPONSE AGAIN
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THE ROLE OF REACTIVE OXIGEN SPECIES
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INNATE AND ADAPTIVE IMMUNE REPONSE
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KINETIC OF THE SPECIFIC HUMMORAL IM
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PURINERGIC RECEPTOR P2Y12 ACTIVATIO
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Evaluation of cytokine and chemokin
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Financial support: This research wa
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COMPARISON OF VIRULENCE AND IMMUNE
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THE IMPACT OF TUBERCULOSIS IN THE I
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GALACTOMANNAN ANTIGENEMIA SCREENING
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NATURAL ISOTYPIC RESPONSE AGAINST P
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Characterization of costimulatory m
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P2X7 RECEPTOR ACTIVATION IS REQUIRE
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CASPASE-1 AND NLRP3 CONTRIBUTE TO T
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circulating Treg cells expressing C
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PBMC, none of the treatments alter
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CHARACTERIZATION OF MONOCYTE SUBSET
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EFFECT OF OUABAIN IN MACROPHAGES IN
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OspC1 AND OspF: VIRULENCE FACTORS I
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Conclusion: Taken together, these r
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FIB produced higher proportion of f
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MØ phenotype M2, resulting in decr
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Financial support FAPESP, CAPES, CN
Page 173 and 174:
ALTERATION IN THE DISTRIBUTION OF P
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BENEFICIAL EFFECTS OF PENTOXIFYLLIN
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MODULATION OF IMMUNE RESPONSE AND C
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FAS/FASL AND TRAIL CAUSE APOPTOSIS
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actin were more frequently detected
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NEUTROPHILS AND MACROPHAGES ARE INV
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EXPLORING THE INFLAMMATORY ROLE OF
Page 187 and 188:
CERVICAL LEVELS OF INTERLEUKIN-1 BE
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Title: IDENTIFICATION BY PHAGE DISP
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PROFILE OF PRO- AND ANTI-INFLAMMATO
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IMMUNOMODULATORY MECHANISMS OF SOLU
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EVALUATION OF THE TH1, TH2 AND TH17
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production, as the blockade of PD-L
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CHARACTERIZATION OF POLYMORPHISM TN
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seems to be dependent on M. leprae
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7 with tendency to normalization on
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CHARACTERIZATION OF THE CONSERVATIO
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ASC INFLAMMASOME IS NECESSARY TO AC
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CASPASE-1 IS REQUIRED TO CONTROL OF
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The role of CD4 + T lymphocytes dur
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CRITICAL ROLE OF MYD88 EXPRESSION I
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on ROS, cathepsin B and Syk kinase
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Financial Support: FAPESP and CNPq.
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80% in symptomatic group; 45% in as
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of cells undergoing apoptosis in DT
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Financial support: FAPESP/LIM-56/HC
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identify the active components and
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EVALUATION OF HUMORAL AND CELULLAR
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Financial support: CNPq-PIBIC, FAPE
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addition, significant expression of
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THE ROLE OF K + TRANSPORTERS IN THE
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Conclusion: In this study, we estab
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Heme activates oxidative mechanisms
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ROLE OF ADENOSINE AND PROSTAGLANDIN
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Taken together, our results indicat
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Conclusion: Our findings suggest th
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Financial support: CNPq, CAPES, IOC
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number of circulating parasites in
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CRITICAL ROLE OF IL-6 IN REGULATORY
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PPAR-α AGONIST GEMFIBROZIL DECREAS
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Cutaneous Leishmaniasis in Amazonas
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CYTOTOXICITY IN IMMUNOPATHOGENESIS
Page 257 and 258:
ROS production and TLR2 and 4 expre
Page 259 and 260:
ROLE OF IL-4 IN THE INTESTINAL INFL
Page 261 and 262:
In vitro CULTURE SYSTEM FOR Plasmod
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interactions, Tandem Affinity Purif
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in the course of human infection wi
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findings suggest that IL-17 and IL-
Page 269 and 270:
23 contribute to immunological cont
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not produced during infection by C.
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Conclusion: The production of cytok
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CONCLUSION: It is likely, in this p
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expression in CCC myocardium was 64
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that mononuclear cells derived from
Page 281 and 282:
Conclusion: Altogether, our data sh
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PARACOCCIDIOIDES BRASILIENSIS INHIB
Page 285 and 286:
CANINE VISCERAL LEISHMANIASIS AND S
Page 287 and 288:
IMMUNOMODULATORY EFFECTS OF BIOTHER
Page 289 and 290:
Leishmania EFFECT ON HEME CYTOTOXIC
Page 291 and 292:
ROLE OF STRONGYLOIDES VENEZUELENSIS
Page 293 and 294:
TREATMENT WITH Harpagophytum procum
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