immunology of infectious and parasitic diseases - XXXVII Congress ...
immunology of infectious and parasitic diseases - XXXVII Congress ...
immunology of infectious and parasitic diseases - XXXVII Congress ...
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INDUCTION OF CD4 + CD25 + FOXP3 + REGULATORY T CELLS DURING<br />
HUMAN HOOKWORM INFECTION MODULATES ANTIGEN-MEDIATED<br />
LYMPHOCYTE PROLIFERATION<br />
NATASHA DELAQUA RICCI (PHD) (1), JACQUELINE ARAÚJO FIÚZA (MSC)<br />
(1,2), LILIAN LACERDA BUENO(PHD) (1), PEDRO HENRIQUE GAZZINELLI<br />
GUIMARÃES (MSC) (1), VIRGILLIO GANDRA MARTINS (IC) (1), GUILHERME<br />
GROSSI CANÇADO(MSC) ,STEFAN MICHAEL GEIGER (PHD) (1) (1),<br />
RODRIGO CAMBRAIA DE MIRANDA (PHD) (1), LEONARDO MATOSO (PHD)<br />
(3), ANDRÉA GAZZINELLI (PD) (3) RODRIGO CORREA-OLIVEIRA (PHD) (2),<br />
DANIELLA CASTANHEIRA BARTHOLOMEU (PHD) (4), RICARDO FUJIWARA<br />
(PHD) (1)<br />
1-Department <strong>of</strong> Parasitology, Federal University <strong>of</strong> Minas Gerais, Belo<br />
Horizonte, Minas Gerais, Brazil<br />
2- Laboratory <strong>of</strong> Cellular <strong>and</strong> Molecular Immunology, Instituto René Rachou,<br />
Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil<br />
3- Nursing School, Federal University <strong>of</strong> Minas Gerais, Belo Horizonte, Minas<br />
Gerais, Brazil<br />
4- Department <strong>of</strong> Biochemistry, Federal University <strong>of</strong> Minas Gerais, Belo<br />
Horizonte, Minas Gerais, Brazil<br />
INTRODUCTION Hookworm infection is considered one <strong>of</strong> the most important<br />
poverty-promoting neglected tropical <strong>diseases</strong>, infecting 576 to 740 million<br />
people worldwide, especially in the tropics <strong>and</strong> subtropics. These blood-feeding<br />
nematodes have a remarkable ability to downmodulate the host immune<br />
response, protecting themselves from elimination <strong>and</strong> minimizing severe host<br />
pathology. While several mechanisms may be involved in the<br />
immunomodulation by <strong>parasitic</strong> infection, experimental evidences have pointed<br />
toward the possible involvement <strong>of</strong> regulatory T cells (Tregs) in downregulating<br />
effector T-cell responses upon chronic infection. However, the role <strong>of</strong> Tregs<br />
cells in human hookworm infection is still poorly understood <strong>and</strong> has not been<br />
addressed yet. METHODS AND RESULTS: In the current study we observed<br />
an augmentation <strong>of</strong> circulating CD4 + CD25 + FOXP3 + regulatory T cells in<br />
hookworm-infected individuals compared with healthy non-infected donors. We<br />
have also demonstrated that infected individuals present higher levels <strong>of</strong>
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