immunology of infectious and parasitic diseases - XXXVII Congress ...

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LYMPHOCYTIC APOPTOSIS IN HUMAN P. FALCIPARUM AND P. VIVAX MALÁRIA: RELATIONSHIP WITH IMUNE RESPONSE TO THE PARASITES EVELYN KETY PRATT RICCIO 1 ; PAULO RENATO RIVAS TOTINO 1 ; VÍTOR ENNES VIDAL 2 ; IRENE DA SILVA SOARES 3 ; MAURÍCIO MARTINS RODRIGUES 4 ; JOSÉ MARIA DE SOUZA 5 ; LILIAN ROSE PRATT-RICCIO 1 ; RENATO PORROZZI DE ALMEIDA 6 ; MARIA DA GLÓRIA BONECINI DE ALMEIDA 7 ; GRAZIELA MARIA ZANINI 8 ; CLÁUDIO TADEU DANIEL RIBEIRO 1 ; MARIA DE FÁTIMA FERREIRA DA CRUZ 1 . 1 Laboratory of Malaria Research, Fiocruz, 2 Laboratory of Molecular Biology and Endemic Disease, Fiocruz, 3 Department of Clinical Analyses and Toxicology, University of São Paulo, 4 Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo, 5 Ambulatory and Laboratory of Malaria Clinical Assays, Instituto Evandro Chagas, 6 Laboratory of Leishmaniasis Research, Fiocruz, 7 Immunology Service of Evandro Chagas Clinical Research Institute, Fiocruz and 8 Parasitology Service, Evandro Chagas Clinical Research Institute, Fiocruz. INTRODUCTION: Infection with Plasmodium is characterized by both activation and suppression of the immune system during the course of the disease. As apoptosis is an important mechanism regulating the activation of lymphocytes, we decided to study the role of lymphocytic apoptosis during a non complicated malaria attack. METHODOLOGY: Blood samples were collected from 35 individuals living in malaria endemic area with positive blood smears, as well as from 17 individuals without previous reported malaria episodes. Apoptosis in T and B cells were analyzed ex–vivo and after 96 hour-culture. Cellular and humoral immune responses after antigenic stimulation, absolute numbers of T and B cells, B cells polyclonal activation and the auto-immune response against components of erythrocytes membrane, cardiolipin, actin and DNA were also investigated. RESULTS: In ex-vivo analyses low levels of apoptosis and high levels of cellular activation in CD4 + cells were observed in malaria patients, although increased levels of early apoptosis in CD4 + and CD8 + cells had been detected. High levels of IFN- and IL-10 and low levels of TNF were also verified in malaria patients. No difference was observed between TNF and IL-10 plasmatic levels between P. vivax and P. falciparum infections, although high levels of IFN- was registered in P. vivax malaria patients. No relationship was observed between cytokines levels and activation, viability or PBMC apoptosis. After 96 hour-culture, apoptosis levels in malaria patients were increased in CD4 + , CD8 + and B cells, and even in the presence of stimuli the cellular proliferation was lower than in healthy individuals. Antibodies against membrane erythrocyte components, cardiolipin and DNA were similarly detected in malaria patients and healthy individuals, while antibodies against
actin were more frequently detected in malaria patients. CONCLUSIONS: The higher levels of apoptosis observed in cells from P. vivax and P. falciparum malaria patients could contribute to lymphopenia associated to malaria. However, the lack of correlation among apoptosis and parasitemia, number of past malaria attacks and low cellular response, specially against malaria antigens, suggest that apoptosis associated to uncomplicated malaria could be a physiological reaction of the immune system to control polyclonal activation and maintain the balance of these cellular population densities. Financial support: CNPq, FAPERJ and FIOCRUZ
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IMMUNOLOGY OF INFECTIOUS AND PARASI
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profiles appear to be dependent on
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INVOLVEMENT OF TNF RECEPTORS IN APO
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Effects of bioactive Cryptococcus n
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DCs expressing Indoleamine 2,3-diox
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DETECTION OF GITR ON PATIENT CERVIX
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DETECTION OF GITR AND IL-10 ON CERV
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VACCINATION WITH SM10.3 ANTIGEN, A
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Financial support: FAPESP, CAPES an
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clearance that follows Sylvio X10/4
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EhMSP-1 - AN ENTAMOEBA HISTOLYTICA
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THERAPY WITH SCFV TRANSFECTED-DENDR
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etween the groups. The results show
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Financial support: FIOCRUZ, CNPq.
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elease of NETs from human neutrophi
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ROLE OF CD18 IN ACTIVATION OF M1 MA
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IDENTIFICATION, PURIFICATION AND CH
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with hemin showed higher levels of
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SEPTIC ARTHRITIS TRIGGERED BY S. au
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eing higher levels induced by a vir
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parasite load skin. The TGF-β was
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cultures, both treatments decreased
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observed a tendency to lower parasi
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SERUM COMPONENTS AND MONONUCLEAR CE
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VIABILITY OF LEISHMANIA (L.) CHAGAS
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EVALUATION OF THE INTERFERENCE OF S
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IMMUNODETECTION OF THE TGF- β IN L
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DIFFERENT LEVELS OF NKT AND NK CELL
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Funding: CNPQ; FAPESPA; SESPA; UFPA
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saliva that exacerbated leishmania
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BACTERIAL FILAMENTATION: SUPER-RESI
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IMMUNOLOGICAL PARAMETERS ASSOCIATED
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supernatant. BMDC stimulation with
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such as number of eosinophils, prot
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EVALUATION OF THE PRODUCTION OF TNF
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Critical motifs of the Anaplasma ma
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SCHISTOSOMA SPP ANTIGENS IMPAIR THE
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DOWN-REGULATION OF IFN-g RECEPTOR A
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MONOCYTES SUBSETS IN SCHISTOSOMIASI
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THE IN VITRO ANALYSIS OF iNOS-KO MO
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CCR7 IS CRITICAL FOR RESISTANCE AGA
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EVALUATION OF THE IMMUNE RESPONSE A
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our data suggest that monocyte secr
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DIVERGENT OUTCOMES OF THE INTERACTI
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they can deactivate immune effector
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Conclusions: We observed a signific
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TLR2 AND TLR4 EXPRESSION AND NUTRIT
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DEVELOPMENT OF MURINE PLACENTAL MAL
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INDUCTION OF TH17 LYMPHOCYTES CONTR
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Leishmania amazonensis INCREASES EC
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TYPE II GRANULOMA INDUCED BY SCHIST
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The Role of Eosinophils in Aspergil
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compared to baseline (p
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disordered loop and NcSAG2A present
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Conclusion: We demonstrate the exis
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WT. By contrast, uninfected AhR -/-
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in the synthesis of proinflammatory
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PRODUCTION AND EVALUATION OF CHICKE
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allow a conclusion about the differ
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contributes to parasite control and
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Financial support: FAPESP, CNPq, an
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MILTEFOSINE EXERTS ITS LEISHMANICID
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IMMUNOMODULATORY ACTIVITIES OF Β-G
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REGULATION OF IMMUNE RESPONSE AGAIN
Page 129 and 130: THE ROLE OF REACTIVE OXIGEN SPECIES
Page 131 and 132: INNATE AND ADAPTIVE IMMUNE REPONSE
Page 133 and 134: KINETIC OF THE SPECIFIC HUMMORAL IM
Page 135 and 136: PURINERGIC RECEPTOR P2Y12 ACTIVATIO
Page 137 and 138: Evaluation of cytokine and chemokin
Page 139 and 140: Financial support: This research wa
Page 141 and 142: COMPARISON OF VIRULENCE AND IMMUNE
Page 143 and 144: THE IMPACT OF TUBERCULOSIS IN THE I
Page 145 and 146: GALACTOMANNAN ANTIGENEMIA SCREENING
Page 147 and 148: NATURAL ISOTYPIC RESPONSE AGAINST P
Page 149 and 150: Characterization of costimulatory m
Page 151 and 152: P2X7 RECEPTOR ACTIVATION IS REQUIRE
Page 153 and 154: CASPASE-1 AND NLRP3 CONTRIBUTE TO T
Page 155 and 156: circulating Treg cells expressing C
Page 157 and 158: PBMC, none of the treatments alter
Page 159 and 160: CHARACTERIZATION OF MONOCYTE SUBSET
Page 161 and 162: EFFECT OF OUABAIN IN MACROPHAGES IN
Page 163 and 164: OspC1 AND OspF: VIRULENCE FACTORS I
Page 165 and 166: Conclusion: Taken together, these r
Page 167 and 168: FIB produced higher proportion of f
Page 169 and 170: MØ phenotype M2, resulting in decr
Page 171 and 172: Financial support FAPESP, CAPES, CN
Page 173 and 174: ALTERATION IN THE DISTRIBUTION OF P
Page 175 and 176: BENEFICIAL EFFECTS OF PENTOXIFYLLIN
Page 177 and 178: MODULATION OF IMMUNE RESPONSE AND C
Page 179: FAS/FASL AND TRAIL CAUSE APOPTOSIS
Page 183 and 184: NEUTROPHILS AND MACROPHAGES ARE INV
Page 185 and 186: EXPLORING THE INFLAMMATORY ROLE OF
Page 187 and 188: CERVICAL LEVELS OF INTERLEUKIN-1 BE
Page 189 and 190: Title: IDENTIFICATION BY PHAGE DISP
Page 191 and 192: PROFILE OF PRO- AND ANTI-INFLAMMATO
Page 193 and 194: IMMUNOMODULATORY MECHANISMS OF SOLU
Page 195 and 196: EVALUATION OF THE TH1, TH2 AND TH17
Page 197 and 198: production, as the blockade of PD-L
Page 199 and 200: CHARACTERIZATION OF POLYMORPHISM TN
Page 201 and 202: seems to be dependent on M. leprae
Page 203 and 204: 7 with tendency to normalization on
Page 205 and 206: CHARACTERIZATION OF THE CONSERVATIO
Page 207 and 208: ASC INFLAMMASOME IS NECESSARY TO AC
Page 209 and 210: CASPASE-1 IS REQUIRED TO CONTROL OF
Page 211 and 212: The role of CD4 + T lymphocytes dur
Page 213 and 214: CRITICAL ROLE OF MYD88 EXPRESSION I
Page 215 and 216: on ROS, cathepsin B and Syk kinase
Page 217 and 218: Financial Support: FAPESP and CNPq.
Page 219 and 220: 80% in symptomatic group; 45% in as
Page 221 and 222: of cells undergoing apoptosis in DT
Page 223 and 224: Financial support: FAPESP/LIM-56/HC
Page 225 and 226: identify the active components and
Page 227 and 228: EVALUATION OF HUMORAL AND CELULLAR
Page 229 and 230: Financial support: CNPq-PIBIC, FAPE
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addition, significant expression of
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THE ROLE OF K + TRANSPORTERS IN THE
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Conclusion: In this study, we estab
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Heme activates oxidative mechanisms
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ROLE OF ADENOSINE AND PROSTAGLANDIN
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Taken together, our results indicat
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Conclusion: Our findings suggest th
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Financial support: CNPq, CAPES, IOC
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number of circulating parasites in
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CRITICAL ROLE OF IL-6 IN REGULATORY
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PPAR-α AGONIST GEMFIBROZIL DECREAS
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Cutaneous Leishmaniasis in Amazonas
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CYTOTOXICITY IN IMMUNOPATHOGENESIS
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ROS production and TLR2 and 4 expre
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ROLE OF IL-4 IN THE INTESTINAL INFL
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In vitro CULTURE SYSTEM FOR Plasmod
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interactions, Tandem Affinity Purif
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in the course of human infection wi
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findings suggest that IL-17 and IL-
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23 contribute to immunological cont
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not produced during infection by C.
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Conclusion: The production of cytok
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CONCLUSION: It is likely, in this p
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expression in CCC myocardium was 64
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that mononuclear cells derived from
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Conclusion: Altogether, our data sh
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PARACOCCIDIOIDES BRASILIENSIS INHIB
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CANINE VISCERAL LEISHMANIASIS AND S
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IMMUNOMODULATORY EFFECTS OF BIOTHER
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Leishmania EFFECT ON HEME CYTOTOXIC
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ROLE OF STRONGYLOIDES VENEZUELENSIS
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TREATMENT WITH Harpagophytum procum
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