immunology of infectious and parasitic diseases - XXXVII Congress ...

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Conclusion: Our preliminary results showed that Th1 response produced by strain S. schenckii 15383 infection, wasn‟t enough to cure the mice, and the less virulent strain induce a mixed Th1/Th2 response. The evaluation of spleen fungal burden suggest that strain 15383 has a tendency to become chronic and strain 1099-18 to move towards healing. From the result of Western blot, can be suggested that the protein with approximately 70kDa from strain 15383 exoantigens, is the most immunoreactive protein. Financial support: FAPESP; CAPES; CNPq.
THE IMPACT OF TUBERCULOSIS IN THE IMMUNE RESPONSE AND CLINICAL CHARACTERISTICS OF HTLV-1 INFECTED SUBJECTS NATÁLIA BARBOSA CARVALHO(1); MARIA DE LOURDES BASTOS(1,2,3); YURI C. S. NEVES(1); ANSELMO SOUZA(1); SILVANE B. SANTOS(1); EDGAR M. CARVALHO(1,2) (1) Serviço de Imunologia do Complexo Hospitalar Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador-BA, Brazil; (2) Escola Bahiana de Medicina e Saúde Pública, Salvador-BA, Brazil; (3) Hospital Especializado Octávio Mangabeira, Salvador-BA, Brazil Introduction: The human T cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that infects mainly T cells, leading to cellular proliferation and activation with exacerbated IFN- and TNF- production. The majority of HTLV- 1 infected patients are considered as HTLV-1 carriers, but some individuals will develop HTLV-1 associated myelopathy (HAM) or overactive bladder (OAB), that is considered an oligosymptomatic form of HAM. It is widely documented that HTLV-1 is associated with increased susceptibility to Mycobacterium tuberculosis infection and severity of tuberculosis. Until now it is unknown if M. tuberculosis influences the outcome of HTLV-1 infection. The aim of this study was to determine the prevalence of tuberculosis (TB) in HTLV-1 infected patients and analyze whether TB influences the immune response, proviral load and the outcome of HTLV-1 infection. Methods and Results: This was a cross-sectional study, in which the prevalence of tuberculosis was analyzed in 136 HTLV-1 infected individuals. Eighteen percent were classified as TB (subjects with positive tuberculin skin test - TST - with previous history of active TB and/or X-ray features of TB), 44% as latent TB (subjects with positive TST without previous history of active TB and X-ray features of TB) and 38% as not TB (subjects without history of TB and with a negative TST). Additionally, we compared the immune response and proviral load of HTLV-1 infected subjects with or without TB. The spontaneous IFN- and TNF- production by PBMCs, analyzed by ELISA, was similar in both groups. There was no difference in the proviral load between the groups, as shown by real time PCR analysis. A contingency analysis demonstrated that there is no difference in the proportion of tuberculosis subjects in asymptomatic, OAB syndrome or HAM groups of HTLV-1 infected subjects.
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IMMUNOLOGY OF INFECTIOUS AND PARASI
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profiles appear to be dependent on
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INVOLVEMENT OF TNF RECEPTORS IN APO
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Effects of bioactive Cryptococcus n
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DCs expressing Indoleamine 2,3-diox
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DETECTION OF GITR ON PATIENT CERVIX
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DETECTION OF GITR AND IL-10 ON CERV
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VACCINATION WITH SM10.3 ANTIGEN, A
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Financial support: FAPESP, CAPES an
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clearance that follows Sylvio X10/4
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EhMSP-1 - AN ENTAMOEBA HISTOLYTICA
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THERAPY WITH SCFV TRANSFECTED-DENDR
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etween the groups. The results show
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Financial support: FIOCRUZ, CNPq.
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elease of NETs from human neutrophi
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ROLE OF CD18 IN ACTIVATION OF M1 MA
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IDENTIFICATION, PURIFICATION AND CH
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with hemin showed higher levels of
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SEPTIC ARTHRITIS TRIGGERED BY S. au
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eing higher levels induced by a vir
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parasite load skin. The TGF-β was
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cultures, both treatments decreased
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observed a tendency to lower parasi
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SERUM COMPONENTS AND MONONUCLEAR CE
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VIABILITY OF LEISHMANIA (L.) CHAGAS
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EVALUATION OF THE INTERFERENCE OF S
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IMMUNODETECTION OF THE TGF- β IN L
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DIFFERENT LEVELS OF NKT AND NK CELL
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Funding: CNPQ; FAPESPA; SESPA; UFPA
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saliva that exacerbated leishmania
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BACTERIAL FILAMENTATION: SUPER-RESI
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IMMUNOLOGICAL PARAMETERS ASSOCIATED
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supernatant. BMDC stimulation with
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such as number of eosinophils, prot
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EVALUATION OF THE PRODUCTION OF TNF
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Critical motifs of the Anaplasma ma
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SCHISTOSOMA SPP ANTIGENS IMPAIR THE
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DOWN-REGULATION OF IFN-g RECEPTOR A
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MONOCYTES SUBSETS IN SCHISTOSOMIASI
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THE IN VITRO ANALYSIS OF iNOS-KO MO
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CCR7 IS CRITICAL FOR RESISTANCE AGA
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EVALUATION OF THE IMMUNE RESPONSE A
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our data suggest that monocyte secr
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DIVERGENT OUTCOMES OF THE INTERACTI
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they can deactivate immune effector
Page 91 and 92: Conclusions: We observed a signific
Page 93 and 94: TLR2 AND TLR4 EXPRESSION AND NUTRIT
Page 95 and 96: DEVELOPMENT OF MURINE PLACENTAL MAL
Page 97 and 98: INDUCTION OF TH17 LYMPHOCYTES CONTR
Page 99 and 100: Leishmania amazonensis INCREASES EC
Page 101 and 102: TYPE II GRANULOMA INDUCED BY SCHIST
Page 103 and 104: The Role of Eosinophils in Aspergil
Page 105 and 106: compared to baseline (p
Page 107 and 108: disordered loop and NcSAG2A present
Page 109 and 110: Conclusion: We demonstrate the exis
Page 111 and 112: WT. By contrast, uninfected AhR -/-
Page 113 and 114: in the synthesis of proinflammatory
Page 115 and 116: PRODUCTION AND EVALUATION OF CHICKE
Page 117 and 118: allow a conclusion about the differ
Page 119 and 120: contributes to parasite control and
Page 121 and 122: Financial support: FAPESP, CNPq, an
Page 123 and 124: MILTEFOSINE EXERTS ITS LEISHMANICID
Page 125 and 126: IMMUNOMODULATORY ACTIVITIES OF Β-G
Page 127 and 128: REGULATION OF IMMUNE RESPONSE AGAIN
Page 129 and 130: THE ROLE OF REACTIVE OXIGEN SPECIES
Page 131 and 132: INNATE AND ADAPTIVE IMMUNE REPONSE
Page 133 and 134: KINETIC OF THE SPECIFIC HUMMORAL IM
Page 135 and 136: PURINERGIC RECEPTOR P2Y12 ACTIVATIO
Page 137 and 138: Evaluation of cytokine and chemokin
Page 139 and 140: Financial support: This research wa
Page 141: COMPARISON OF VIRULENCE AND IMMUNE
Page 145 and 146: GALACTOMANNAN ANTIGENEMIA SCREENING
Page 147 and 148: NATURAL ISOTYPIC RESPONSE AGAINST P
Page 149 and 150: Characterization of costimulatory m
Page 151 and 152: P2X7 RECEPTOR ACTIVATION IS REQUIRE
Page 153 and 154: CASPASE-1 AND NLRP3 CONTRIBUTE TO T
Page 155 and 156: circulating Treg cells expressing C
Page 157 and 158: PBMC, none of the treatments alter
Page 159 and 160: CHARACTERIZATION OF MONOCYTE SUBSET
Page 161 and 162: EFFECT OF OUABAIN IN MACROPHAGES IN
Page 163 and 164: OspC1 AND OspF: VIRULENCE FACTORS I
Page 165 and 166: Conclusion: Taken together, these r
Page 167 and 168: FIB produced higher proportion of f
Page 169 and 170: MØ phenotype M2, resulting in decr
Page 171 and 172: Financial support FAPESP, CAPES, CN
Page 173 and 174: ALTERATION IN THE DISTRIBUTION OF P
Page 175 and 176: BENEFICIAL EFFECTS OF PENTOXIFYLLIN
Page 177 and 178: MODULATION OF IMMUNE RESPONSE AND C
Page 179 and 180: FAS/FASL AND TRAIL CAUSE APOPTOSIS
Page 181 and 182: actin were more frequently detected
Page 183 and 184: NEUTROPHILS AND MACROPHAGES ARE INV
Page 185 and 186: EXPLORING THE INFLAMMATORY ROLE OF
Page 187 and 188: CERVICAL LEVELS OF INTERLEUKIN-1 BE
Page 189 and 190: Title: IDENTIFICATION BY PHAGE DISP
Page 191 and 192: PROFILE OF PRO- AND ANTI-INFLAMMATO
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IMMUNOMODULATORY MECHANISMS OF SOLU
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EVALUATION OF THE TH1, TH2 AND TH17
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production, as the blockade of PD-L
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CHARACTERIZATION OF POLYMORPHISM TN
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seems to be dependent on M. leprae
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7 with tendency to normalization on
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CHARACTERIZATION OF THE CONSERVATIO
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ASC INFLAMMASOME IS NECESSARY TO AC
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CASPASE-1 IS REQUIRED TO CONTROL OF
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The role of CD4 + T lymphocytes dur
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CRITICAL ROLE OF MYD88 EXPRESSION I
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on ROS, cathepsin B and Syk kinase
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Financial Support: FAPESP and CNPq.
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80% in symptomatic group; 45% in as
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of cells undergoing apoptosis in DT
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Financial support: FAPESP/LIM-56/HC
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identify the active components and
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EVALUATION OF HUMORAL AND CELULLAR
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Financial support: CNPq-PIBIC, FAPE
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addition, significant expression of
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THE ROLE OF K + TRANSPORTERS IN THE
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Conclusion: In this study, we estab
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Heme activates oxidative mechanisms
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ROLE OF ADENOSINE AND PROSTAGLANDIN
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Taken together, our results indicat
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Conclusion: Our findings suggest th
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Financial support: CNPq, CAPES, IOC
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number of circulating parasites in
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CRITICAL ROLE OF IL-6 IN REGULATORY
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PPAR-α AGONIST GEMFIBROZIL DECREAS
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Cutaneous Leishmaniasis in Amazonas
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CYTOTOXICITY IN IMMUNOPATHOGENESIS
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ROS production and TLR2 and 4 expre
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ROLE OF IL-4 IN THE INTESTINAL INFL
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In vitro CULTURE SYSTEM FOR Plasmod
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interactions, Tandem Affinity Purif
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in the course of human infection wi
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findings suggest that IL-17 and IL-
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23 contribute to immunological cont
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not produced during infection by C.
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Conclusion: The production of cytok
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CONCLUSION: It is likely, in this p
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expression in CCC myocardium was 64
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that mononuclear cells derived from
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Conclusion: Altogether, our data sh
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PARACOCCIDIOIDES BRASILIENSIS INHIB
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CANINE VISCERAL LEISHMANIASIS AND S
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IMMUNOMODULATORY EFFECTS OF BIOTHER
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Leishmania EFFECT ON HEME CYTOTOXIC
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ROLE OF STRONGYLOIDES VENEZUELENSIS
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TREATMENT WITH Harpagophytum procum
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