immunology of infectious and parasitic diseases - XXXVII Congress ...

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endemic controls (n=39) from an endemic area in the Northeast of Brazil. Patients with VL presented higher concentrations of total heme in the serum (62.25M±5.739) compared to health individuals (23.86M±2.273). Conclusion: Taken together, our data suggest that heme contributes to the pathogenesis of VL and reinforces the idea that L. chagasi parasite modulates host immune responses. Financial support: FAPESB, CNPq, INCT-iii
ROLE OF STRONGYLOIDES VENEZUELENSIS INFECTION IN THE EVOLUTION OF EXPERIMENTALLY INDUCED COLITIS IN MICE Rodrigues, VF1; Bahia, MPS1; Cândido, NR1; Pereira, CAJ1; Araújo, ES1; Rodrigues, JL1; Corrêa, O1; Negrão-Corrêa, D1. 1 – Universidade Federal de Minas Gerais Introduction:The infection with intestinal nematode, such as Strongyloides, induces a modified type-2 immune response, in which cytokines of type 2 and regulatory are produced. Epidemiologic studies suggested that nematodeinduced immune response also has the ability to modulate unrelated inflammation such as inflammatory bowel disease (IBD), a chronic inflammatory disorder that manifests in a dysregulated mucosal immune response against intestinal bacteria. However, the mechanisms involved in this modulation process are not well established and is probably dependent on the nematode life cycle. In this experimental work, we intent to verify the effect of Strongyloides venezuelensis infection, a nematode that establishes into the small intestine mucosa and it is spontaneously eliminated after 2 weeks, infection on the evolution of Dextran sodium sulfate (DSS)-induced colitis in mice. Methods and Results:For this proposal, Balb/c female mice were subcutaneously infected with 700 L3 of S. venezuelensis and after 5 days they received drinking water containing 4 % of DSS for 7 days. Groups of Balb/c only infected or only treated with DSS were kept as control. Colitis score was determined based on weight loss, fecal blood and diarrhea, and clinical appearance. Upon autopsy, at 12 days of infection, parasite burden and the length of the colon were determined. Samples of small and large intestine were recovered for cytokine quantification and histopatologic analysis. The data showed that DSS-induced colitis did not interfere with the parasite burden, but S. venezuelensis infection significantly reduced the colitis score. Compare to DSS-treated mice, the infected and treated animals also showed lower cellular infiltration and mieloperoxidase activity, but higher eosinophil peroxidase in colon. At the time of autopsy, the colon of mice infected and DSS-treated mice had higher levels of type-2 cytokines (IL-4 and IL-13) but similar levels of IL-10 and type-1 cytokine compare to DSS-treated mice. Conclusion:Our data indicates that S. venezuelensis infection is able to modulate DSS-induced colitis in mice. The results also suggested that the modulation was due to the increase of type-2 response in colon. Financial support: Fapemig e CNPq
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IMMUNOLOGY OF INFECTIOUS AND PARASI
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profiles appear to be dependent on
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INVOLVEMENT OF TNF RECEPTORS IN APO
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Effects of bioactive Cryptococcus n
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DCs expressing Indoleamine 2,3-diox
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DETECTION OF GITR ON PATIENT CERVIX
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DETECTION OF GITR AND IL-10 ON CERV
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VACCINATION WITH SM10.3 ANTIGEN, A
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Financial support: FAPESP, CAPES an
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clearance that follows Sylvio X10/4
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EhMSP-1 - AN ENTAMOEBA HISTOLYTICA
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THERAPY WITH SCFV TRANSFECTED-DENDR
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etween the groups. The results show
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Financial support: FIOCRUZ, CNPq.
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elease of NETs from human neutrophi
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ROLE OF CD18 IN ACTIVATION OF M1 MA
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IDENTIFICATION, PURIFICATION AND CH
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with hemin showed higher levels of
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SEPTIC ARTHRITIS TRIGGERED BY S. au
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eing higher levels induced by a vir
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parasite load skin. The TGF-β was
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cultures, both treatments decreased
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observed a tendency to lower parasi
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SERUM COMPONENTS AND MONONUCLEAR CE
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VIABILITY OF LEISHMANIA (L.) CHAGAS
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EVALUATION OF THE INTERFERENCE OF S
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IMMUNODETECTION OF THE TGF- β IN L
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DIFFERENT LEVELS OF NKT AND NK CELL
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Funding: CNPQ; FAPESPA; SESPA; UFPA
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saliva that exacerbated leishmania
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BACTERIAL FILAMENTATION: SUPER-RESI
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IMMUNOLOGICAL PARAMETERS ASSOCIATED
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supernatant. BMDC stimulation with
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such as number of eosinophils, prot
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EVALUATION OF THE PRODUCTION OF TNF
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Critical motifs of the Anaplasma ma
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SCHISTOSOMA SPP ANTIGENS IMPAIR THE
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DOWN-REGULATION OF IFN-g RECEPTOR A
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MONOCYTES SUBSETS IN SCHISTOSOMIASI
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THE IN VITRO ANALYSIS OF iNOS-KO MO
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CCR7 IS CRITICAL FOR RESISTANCE AGA
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EVALUATION OF THE IMMUNE RESPONSE A
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our data suggest that monocyte secr
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DIVERGENT OUTCOMES OF THE INTERACTI
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they can deactivate immune effector
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Conclusions: We observed a signific
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TLR2 AND TLR4 EXPRESSION AND NUTRIT
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DEVELOPMENT OF MURINE PLACENTAL MAL
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INDUCTION OF TH17 LYMPHOCYTES CONTR
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Leishmania amazonensis INCREASES EC
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TYPE II GRANULOMA INDUCED BY SCHIST
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The Role of Eosinophils in Aspergil
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compared to baseline (p
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disordered loop and NcSAG2A present
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Conclusion: We demonstrate the exis
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WT. By contrast, uninfected AhR -/-
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in the synthesis of proinflammatory
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PRODUCTION AND EVALUATION OF CHICKE
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allow a conclusion about the differ
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contributes to parasite control and
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Financial support: FAPESP, CNPq, an
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MILTEFOSINE EXERTS ITS LEISHMANICID
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IMMUNOMODULATORY ACTIVITIES OF Β-G
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REGULATION OF IMMUNE RESPONSE AGAIN
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THE ROLE OF REACTIVE OXIGEN SPECIES
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INNATE AND ADAPTIVE IMMUNE REPONSE
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KINETIC OF THE SPECIFIC HUMMORAL IM
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PURINERGIC RECEPTOR P2Y12 ACTIVATIO
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Evaluation of cytokine and chemokin
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Financial support: This research wa
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COMPARISON OF VIRULENCE AND IMMUNE
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THE IMPACT OF TUBERCULOSIS IN THE I
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GALACTOMANNAN ANTIGENEMIA SCREENING
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NATURAL ISOTYPIC RESPONSE AGAINST P
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Characterization of costimulatory m
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P2X7 RECEPTOR ACTIVATION IS REQUIRE
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CASPASE-1 AND NLRP3 CONTRIBUTE TO T
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circulating Treg cells expressing C
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PBMC, none of the treatments alter
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CHARACTERIZATION OF MONOCYTE SUBSET
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EFFECT OF OUABAIN IN MACROPHAGES IN
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OspC1 AND OspF: VIRULENCE FACTORS I
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Conclusion: Taken together, these r
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FIB produced higher proportion of f
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MØ phenotype M2, resulting in decr
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Financial support FAPESP, CAPES, CN
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ALTERATION IN THE DISTRIBUTION OF P
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BENEFICIAL EFFECTS OF PENTOXIFYLLIN
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MODULATION OF IMMUNE RESPONSE AND C
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FAS/FASL AND TRAIL CAUSE APOPTOSIS
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actin were more frequently detected
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NEUTROPHILS AND MACROPHAGES ARE INV
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EXPLORING THE INFLAMMATORY ROLE OF
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CERVICAL LEVELS OF INTERLEUKIN-1 BE
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Title: IDENTIFICATION BY PHAGE DISP
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PROFILE OF PRO- AND ANTI-INFLAMMATO
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IMMUNOMODULATORY MECHANISMS OF SOLU
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EVALUATION OF THE TH1, TH2 AND TH17
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production, as the blockade of PD-L
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CHARACTERIZATION OF POLYMORPHISM TN
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seems to be dependent on M. leprae
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7 with tendency to normalization on
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CHARACTERIZATION OF THE CONSERVATIO
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ASC INFLAMMASOME IS NECESSARY TO AC
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CASPASE-1 IS REQUIRED TO CONTROL OF
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The role of CD4 + T lymphocytes dur
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CRITICAL ROLE OF MYD88 EXPRESSION I
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on ROS, cathepsin B and Syk kinase
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Financial Support: FAPESP and CNPq.
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80% in symptomatic group; 45% in as
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of cells undergoing apoptosis in DT
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Financial support: FAPESP/LIM-56/HC
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identify the active components and
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EVALUATION OF HUMORAL AND CELULLAR
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Financial support: CNPq-PIBIC, FAPE
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addition, significant expression of
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THE ROLE OF K + TRANSPORTERS IN THE
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Conclusion: In this study, we estab
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Heme activates oxidative mechanisms
Page 239 and 240: ROLE OF ADENOSINE AND PROSTAGLANDIN
Page 241 and 242: Taken together, our results indicat
Page 243 and 244: Conclusion: Our findings suggest th
Page 245 and 246: Financial support: CNPq, CAPES, IOC
Page 247 and 248: number of circulating parasites in
Page 249 and 250: CRITICAL ROLE OF IL-6 IN REGULATORY
Page 251 and 252: PPAR-α AGONIST GEMFIBROZIL DECREAS
Page 253 and 254: Cutaneous Leishmaniasis in Amazonas
Page 255 and 256: CYTOTOXICITY IN IMMUNOPATHOGENESIS
Page 257 and 258: ROS production and TLR2 and 4 expre
Page 259 and 260: ROLE OF IL-4 IN THE INTESTINAL INFL
Page 261 and 262: In vitro CULTURE SYSTEM FOR Plasmod
Page 263 and 264: interactions, Tandem Affinity Purif
Page 265 and 266: in the course of human infection wi
Page 267 and 268: findings suggest that IL-17 and IL-
Page 269 and 270: 23 contribute to immunological cont
Page 271 and 272: not produced during infection by C.
Page 273 and 274: Conclusion: The production of cytok
Page 275 and 276: CONCLUSION: It is likely, in this p
Page 277 and 278: expression in CCC myocardium was 64
Page 279 and 280: that mononuclear cells derived from
Page 281 and 282: Conclusion: Altogether, our data sh
Page 283 and 284: PARACOCCIDIOIDES BRASILIENSIS INHIB
Page 285 and 286: CANINE VISCERAL LEISHMANIASIS AND S
Page 287 and 288: IMMUNOMODULATORY EFFECTS OF BIOTHER
Page 289: Leishmania EFFECT ON HEME CYTOTOXIC
Page 293 and 294: TREATMENT WITH Harpagophytum procum
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