Fallet Magnus

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Pervasive Developmental Disorders in Preschool Children: Confirmation of High Prevalence Suniti Chakrabarti, M.D., F.R.C.P.C.H., M.R.C.P., and Eric Fombonne, M.D., F.R.C.Psych. OBJECTIVE: The rate of reported pervasive developmental disorders has increased, and the authors found a rate of 62.6 per 10,000 in a previous study of preschoolers in Stafford, U.K. They conducted another survey in 2002 to estimate the prevalence in children in a later birth cohort and to compare it to previous findings from the same area. METHOD: Screening for developmental problems included 10,903 children ages 4.0 to 6.0 years who were living in a Midlands town on the survey date. Children with symptoms suggestive of pervasive developmental disorders were intensively assessed by a multidisciplinary team using standardized diagnostic interviews, psychometric tests, and medical workups. RESULTS: Sixty-four children (85.9% boys) were diagnosed with pervasive developmental disorders. The prevalence was 58.7 per 10,000, with a 95% confidence interval (CI) of 45.2–74.9, for all pervasive developmental disorders, 22.0 per 10,000 (95% CI=14.1–32.7) for autistic disorder, and 36.7 per 10,000 (95% CI=26.2–49.9) for other variants. These rates were not significantly different from the previous rates. The mean age at diagnosis was 37.8 months, and 53.1% of the children were originally referred by health visitors. Of the 64 children with pervasive developmental disorders, 29.8% had mental retardation, but this rate varied by disorder subtype. Few children had associated medical conditions. CONCLUSIONS: The rate of pervasive developmental disorders is higher than reported 15 years ago. The rate in this study is comparable to that in previous birth cohorts from the same area and surveyed with the same methods, suggesting a stable incidence. Titeln och första meningen talar om en ökning och HÖG incidens Läkaren som skickade studien skrev: ”Ett vittne som använder studien på det sättet försöker vilseleda domstolen.” Som läsarna själva kan se skriver Chakrabarti om en kraftig ökning. Läkaren som skickade studien till mig skrev att ”ett vittne som använder studien på det sättet försöker vilseleda domstolen”. I det sammanhanget kan jag nämna Island igen, där man i en homogen befolkning, med samma diagnoskriterier, noterar en kraftig ökning. Fernell påstår att det inte finns några studier som visar att sekretin har någon effekt. Double Blind Crossover Study of Secretin/Secrepan Treatment for Children with Autistic Symptoms Shin-Siung Jung, Peter Chuan-Hsong Kao1, Yueh-Chieng Lee2 Springtide Foundation of Taiepi City, Taipei, Taiwan; Autism Society of Taiwan1, Taipei, Taiwan; Chin- Hwa Elementary School of Taipei City2, Taipei, Taiwan ABSTRACT Objective: A double blind crossover study of secretin/secrepan treatment for autistic children. Materials and Methods: Through the encouragement of the autism association, 58 autistic children participated this study. The children were matched into two teams according to sex, age, body weight, and language ability, then randomly assigned into experimental and placebo groups. The children in experimental group received secrepan 50cu intra-muscularly and those in the placebo group received an injection of normal saline 2 cc. Both were observed for six weeks and then crossovers for the second injection series, followed by further observation for another sex weeks. Special attention was paid to allergic history and the management of allergic attack. Wilcoxon- Mann-Whitney and Chi-square tests were used for analyzing data and comparing both groups, and a Wilcoxon-signed ranks test was used for the pre-test and post-test analysis. Results: Overall assessment indicated a better efficacy for the experimental group, than for the controls (p < 0.05 ), in which the sum of a moderate improvement (20%) and a mild improvement (60%) denotes 80% effectiveness. Active improved symptoms include better language expression, better sleep pattern, better eye contact, and better socialization activity, which lasted for six to twelve weeks. Adverse side-effects of secrepan (31% of subjects ) include emotional irritability , hyperactivity, and insomnia, although their frequency could not be differentiated from fluctuations in autistic symptoms. Severe fluctuation of autistic symptoms with weekly worsening and re-improved rate around 17%-20% was noted. No allergic reaction to the medication was observed in the short period.Conslusion: Secretin/Secrepan is helpful to autistic children, assisting around 80% with a mild to moderate improvement . This is still not an overall improvement or a cure for such autistic symptoms, but it is very helpful for parental management. (Tzu Chi Med J 2000; 12:173-181) Key words: autism, secretin, secrepan 66
Som läsarna själva kan se finns det sådana studier och effektiviteten är 80 %. Vi kan själva intyga att sekretin är bra. Det fungerade alldeles utmärkt på <strong>Magnus</strong>. Fernell säger sig ha använt sekretin utan effekt. Dock har många andra läkare använt sekretin med framgång. I kontroversen som uppstod har läkare kommenterat att när en inkompetent och okunnig läkare ger för låga doser under för kort tid uteblir naturligtvis effekten. Fernell påstår att det inte finns några studier som visar ett klart samband mellan tarmproblem och autism. 45 studier har tidigare lämnats in som bevis i målet: 2000 STUDIES CONFIRMING WAKEFIELD Anthony A, Sim R, Guillaume JL, Strosberg AD, Dhillon AP, Pounder RE, Wakefield AJ. Beta (beta)3-adrenergic receptors in human pancreatic islet and duodenal somatostatin neuroendocrine cells. Alimentary Pharmacology and Therapeutics. 2000;14:579-8 Anthony A, Sim R, Pounder RE, Dhillon AP, Wakefield AJ. Similarities between Crohn's disease and indomethacin experimental ulcers in the rat. Alimentary Pharmacology and Therpeutics. 2000;14:241-245 Kawashima H., Takayuki M., Kashiwagi Y., Takekuma K., Hoshika A., Wakefield AJ. Detection and sequencing of measles virus from peripheral blood mononuclear cells from patients with inflammatory bowel disease and autism. Digestive Diseases and Sciences. 2000;45:723-729 Kelly D, Anthony A, Piasecki C, Lewin J, Pounder RE, Wakefield AJ. Endothelial changes precede mucosal ulceration induced by indomethacin: an experimental study in the rat. Alimentary Pharmacology and Therapeutics. 2000;14:489-96 Montgomery SM, Wakefield AJ, Morris DL, Pounder RE, Murch SH. The initial care of newborn infants and subsequent hay fever. Allergy. 2000 Oct;55(10):916-22. Morris DL, Montgomery SM, Thompson NP, Ebrahim S, Pounder RE, Wakefield AJ. Measles vaccination and inflammatory bowel disease: a national British Cohort Study. Am J Gastroenterol. 2000 Dec;95(12):3507-12. Morris DL, Montgomery SM. Early environmental factors may have role in both Crohn's disease and gastric carcinoma. BMJ. 2000 Nov 18;321(7271):1291 O'Leary JJ, Uhlmann V, Wakefield AJ. Measles virus and autism. Lancet. 2000 Aug 26;356(9231):772. Thompson NP., Montgomery SM., Wadsworth MEJ., Pounder RE., Wakefield AJ. Early determinants of inflammatory bowel disease: use of two longitudinal birth cohorts. European Journal of Gastroenterology & Hepatology. 2000;12:25-30 Wakefield AJ, Anthony A, Murch SH, Thomson, Montgomery SM, O’Leary JJ, Berelowitz M, Walker-Smith JA. Enterocolitis in children with developmental disorders. Am J Gastro 2000 Sep 95(9):2285-95 Wakefield AJ, Montgomery SM. Measles virus as a risk for inflammatory bowel disease: an unusually tolerant approach. Am J Gastroenterol. 2000 Jun;95(6):1389-92. Review. 67
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Fallet Magnus - orsakas autism av a
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Klausulens genetiska krav Vad betyd
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Som klargjorts ovan är klausulen t
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evidence indicates that their origi
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nödvändighet, och gjorde därför
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också att vissa familjer tycks var
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Trots denna avsaknad av bevis för
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Page 17 and 18: Studien från 1997 finns naturligtv
Page 19 and 20: För att ge ett exempel. I princip
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Page 23 and 24: inte dra fasta slutsatser från vå
Page 25 and 26: En icke-autist 7 par 10 par Den hel
Page 27 and 28: I sitt referat av F & R kommenterar
Page 29 and 30: Tvillingfödslar och vissa kognitiv
Page 31 and 32: Genome Project har fått miljoner o
Page 33 and 34: Huvudfrågan i Rutters rapport är
Page 35 and 36: Den bakomliggande logiken synes var
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Page 39 and 40: En av de godtyckligheter som ligger
Page 41 and 42: http://bmj.bmjjournals.com/cgi/cont
Page 43 and 44: en, han haltar svårt på just det
Page 45 and 46: Rutter kan erbjudas en enkel möjli
Page 47 and 48: Sådana begrepp tillåter i princip
Page 49 and 50: lika lite som Rutter - några metod
Page 51 and 52: Efter att ha läst rapporterna kan
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Page 55 and 56: av något slag. Utrymmet för skön
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Page 59 and 60: föräldrarnas sakkunniga. Motparte
Page 61 and 62: Rutter säger sedan att enbart en m
Page 63 and 64: Hur som helst visar studiens egna s
Page 65: Bailey tycks medge att Kanner bara
Page 69 and 70: Montgomery SM, Lambe M, Wakefield A
Page 71 and 72: Fernells iver att avfärda alla mil
Page 73 and 74: Då blir majoriteten av barnen bät
Page 75 and 76: det gäller autism drabbas ovaccine
Page 77 and 78: psykiatri och psykologi, med titeln
Page 79 and 80: epidemiologiska studierna av autist
Page 81 and 82: Logiken i det här kan ifrågasätt
Page 83 and 84: Palmgren ironiserar över att jag g
Page 85 and 86: yttrande från en professor i genet
Page 87 and 88: Sammanfattning av jämförelse av b
Page 89 and 90: Last slide Orsakar abnorma EEG, epi
Page 91 and 92: 3 Ileal-lymphoid-nodular hyperplasi
Page 93 and 94: Autism: bekämpningsmedel på gård
Page 95 and 96: autism orsakas av häxeri eller uto
Page 97 and 98: autism nödvändigtvis har orsakats
Page 99 and 100: element, precis som alla andra sjuk
Page 101 and 102: Först utgår man ifrån att det ka
Page 103 and 104: Banden mellan industrimedicinen och
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