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Elephants Elephants - Wildpro - Twycross Zoo

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112<br />

than 20mls should be injected at any one site to avoid swelling and<br />

inflammation. Abscesses form readily in elephants and it is essential that the<br />

skin is cleaned thoroughly with disinfectant before an injection is made.<br />

Injections in hind legs require 6-9cm needles. Intravenous injections are<br />

generally made into the veins on the posterior aspect of the ear, but leg veins<br />

can be used in some animals. Perivascular injection should be avoided as it<br />

may lead to local necrosis & sloughing particularly when using flunixin<br />

meglumine (Finadyne). For large volumes of intravenously administered<br />

drugs, an intravenous cannula is advised.<br />

<strong>Elephants</strong> should be restrained when being injected and the veterinarian<br />

MUST always bear in mind safety considerations should the animal object.<br />

It is highly questionable whether adequate absorption occurs from the<br />

subcutaneous space in elephants and generally this route should be avoided.<br />

However, it is possible that some drugs could be administered per rectum.<br />

One report describes the pharmacokinetics of rectally administered<br />

metronidazole (Gulland and Carwardine 1987).<br />

In very general terms, antibiotics and other drugs are given at same dose rates<br />

as for horses and cattle (Schmidt 1986) unless specific pharmacokinetic data is<br />

available for the elephant. Such data is unavailable for the majority of drugs.<br />

A table of known effective dose rates for some antibiotics is given below.<br />

Olsen (1999) gives details of weight estimation and dosage calculations.<br />

Drug Dose Route Frequency Comments<br />

Amoxycillin 11mg/kg IM 1 x daily (Olsen 1999)<br />

Ampicillin 8mg/kg PO 2-3 x daily (Olsen 1999)<br />

Enrofloxacin 2.5mg/kg PO 1 x daily (Olsen 1999)<br />

Enrofloxacin 1.25mg/kg PO 2 x daily (Olsen 1999)<br />

Gentamycin 4.4mg/kg IM/ IV 1 x daily (Olsen 1999)<br />

Isoniazid 5mg/kg PO 1 x daily (Mikota et al 2001)<br />

Metronidazole 15mg/kg PR 1 x daily Give iron supplement<br />

Pyrazinamide 25-35<br />

mg/kg<br />

PO 1 x daily (Mikota et al 2001)1<br />

Rifampicin 7.5-10<br />

mg/kg<br />

PO 1 x daily (Mikota et al 2001)<br />

Tetracycline 20mg/kg IM Every<br />

48hrs<br />

(Olsen 1999)<br />

Trimethaprimsulphamethoxazole<br />

22mg/kg PO 2 x daily (Olsen 1999)<br />

Tylosin 12mg/kg IM 1 x daily (Schmidt 1986)<br />

Anaesthesia and Sedation<br />

This section provides general information on the topic. It is not intended to be<br />

a comprehensive guide and for more detailed information reference should be<br />

made to the veterinary texts listed in the reference list e.g. (Fowler et al 2000)<br />

(Fowler and Miller 1998).<br />

Sedatives include:

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