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(stereochem.) In an effort to obtain a salvinorin derivative possessing an α-diol system which can be transformed into the dibenzoate ester required for the exciton chirality CD method, salvinorin A (1) or B (2) was treated with sodium borohydride in various protic solvents. The products having the 1α,2α-diol group were obtained in high yield. However, this reduction was accompanied by extensive isomerization at C-8. While mechanistic details for this unexpected observation remain to be established at this time, the isomerization at C-8 appears to be the result of the base-promoted clevage of the C-8/9 bond under the reaction conditions followed by the reclosure to provide the 8-epimer prior to the reduction of the 1ketone. Furthermore, attempts to obtain the 1,2-dibenzoate derivative of the major reduction product 3 under various benzoylating conditions invariably produced only the 2-monobenzoate. Since it was deemed desirable to remove possible interaction between the benzoate and the furan chromophores for the unambiguous CD analysis, salvinorin A (1) was reduced under cataytic hydrogenation conditions, providing the hexahydro derivative 4 (a 2:1 epimeric mixture at C-13) after esterification with diazomethane and desacetylation with KCN/MeOH. 6) Interestingly, ester 4 was found to be relatively stable towards configurational isomerization at C-8. Thus, reduction of 4 with NaBH4 in EtOH produced cleanly the cis-1α,2α-diol 5 in 81% yield. The benzoylation of the 1-α-hydroxyl group in 5, which is surrounded by the two 1,3-diaxially juxtaposed methyl groups, proved to be quite difficult under the standard benzoylation conditions. However, treatment of 5 with trimethyl orthobenzoate at 100°C in the presence of a catalytic amount of benzoic acid followed by acid-catalysed hydrolysis of the resulting 1,2-cyclic orthobenzoate provided the 1-monobenzoate derivative of 5. 7,8) Benzoylation of this monobenzoate under standard conditions afforded the desired 1,2-dibenzoate 69) in 95% yield. Alternatively, treatment of diol 5 with benzoyl triflouromethanesulfonate (BzOTf) 10) resulted in the direct formation of 6 in 50%yield. http://www.sagewisdom.org/stereochemistry.html (2 of 5) [04.09.01 10:21:59]
(stereochem.) Fig. 1. The negative chirality between the two benzoate electric transition dipoles of the 1,2-dibenzoate derivative 6. http://www.sagewisdom.org/stereochemistry.html (3 of 5) [04.09.01 10:21:59]
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The Salvia divinorum Research and I
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