Environmental and Molecular Mutagenesis - Legacy Tobacco ...

198 1989 EMS Abstracts
_,_-- - .-
Notes "`i`A"'the case bgtw&WINDEA and NDMA . With regard to detectability of minimum
dose foEr a chemical using Tradescantia stamen hair system, this depends
upon the kigl'6of chemical and test clones . It may be stated that
an effective-8ase`for inducing mutations is in the order of picograms of
chemicals per flower . Therefore, Tradescantia may be possible to use as
one of the indicators for risk evaluation of chemical mutagens .
http://legacy.library.ucsf.edu/tid/clb93d00/pdf
MUTAGENIC EFFECTS OF ENVIRONMENTAL RADON
Tavera L ., BalcBzar M ., de la Rosa M . E ., 2immering S .*
ININ . Sierra MoJada N447 . 2 y 3er . pisos . Col . Lomas Barrilaco C .P .11010 .MEXICO
*Brown University, Providence U .S .A .
574
The internal radon progeny exposure exhibits a distinct maximum dose In the respiratory
tract Inducing lung cancer .
From epidemiological data available only a statistical significance Increase of cancer
frequency with Increasing background radiation can be deduced . Because of these data
are given for different ages and radiation environments a Radon Chamber was desloned to
exposure bioassays for searching effects other than cancer induced by radon exposure .
The radon atmosphere in the chamber reach 97% of saturation after 19 days, however it
is possible to determine an equivalent average radon concentration by means of Solid
State Track Detectors . The Radon daughters assessment Is also possible with these detectors
.
Samples of Drosophila exposured in this Radon Chamber have shown inter-and-Intraspecie
differences in sensibility when fecundity and viability were measured . Additionally a
very typical aberrant phenotype was induced in D . melanogaster wild-type .
575
GENOTOXICITY ASSESSMENT OF QUINAPRIL, A NEW ANTIHYPERTENSIVE DRUG . J .C . Theiss, N .L .
Kropko, G . Krishna, and V . Ciaravino, Parke-Davis pharm . Res . Div ., Warner-Lambert Co .,
Ann Arbor, MI(USA)
Quinapril was assessed for genotoxicity in a variety of test systems . This drug was
not mutagenic toward S . typhimurium (10,000 ug/plate highest dose tested) and did not
increase the mutant or SCE frequency in V79 cells (1400 ug/ml highest concentration
tested) . Quinapril did not induce micronuclei in mice (1430 mg/kg high dose-80% mouse
LD50) nor did it induce structural chromosomal aberrations (SCAs) in rats (2130 mg/kg
high dose-rat LD10) . Thus, quinapril was not clastogenic in vivo at doses far in excess
of the maximum human dose of 1 mg/kg . There was a slight but statistically significant
dose-related increase in SCAs in V79 cells treated with quinapril for 3 hours which
occurred in the presence of S9 only and at 18 hours post-exposure only (12, 18, 24, and
40 hour time points) . The maximun frequency of cells with SCAs detected (6t) was within
the historical control range for this laboratory (0-6 .31 cells with SCAs, n-31) and the
minimum concentration at which an increase in SCAs occurred (1400 ug/ml) was cytotoxic
(