Environmental and Molecular Mutagenesis - Legacy Tobacco ...

218 1989 EMS Abstracts . - --
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Notes ~ t . :o pro':oco?.s '-re u^ed : 1 . for "in v!vo" n-,n-uremcnt In hone m~arrorr
ec' .1c 50 .mg V)iAte of rromo9.coxyuri3inc (BrdU) •.•rre implant^d 2Q4 h beio--'c
'"±'~-ir~ o`"^n3'~^1^ ; 2 . `.or "in vitro" ~+e?-ttrement ^plecn 1ymFhocvtee
t•rere cu].tvre :? ~~Str °r' (6/ .tz ~er ml) . The induction of SCy in
~-tre^.ted ^.^7LJ.C ^nd ^7A^ mice "in vivo" :,^s 1 .21 ^nd ti .07-fold, roo-
~°etively . "In vitro" th^ re~ictive v^?t .ies •-erc 1,^9 and 2 .73 .
The ob~-erved ?nter^trpin differences In in3action of SC2, were much
Qre^.t^r 7n hone n .r=ov~ "in v3vo" ^ .- compared to ^rleen 1•m?hoc?rte3
http://legacy.library.ucsf.edu/tid/clb93d00/pdf
ttin vi t'"o" "2re A+rr„r^•tCe T~a•r re .%tlt frOm ~^.~ f^Ct fi .^t At+_ring 'tin
vi tro" teqt cel?.r P_o not e :~o'rcd tc =1, a- c•ell ?^ from hicher fre-
^uencieo of SC2 !n ce].13 culturQd " .'.n v!tro" . "_'!•ir• mey Indicate th2t
z.so in c;m V+.e 'in vivo" tent3 !b :° aasa^ament of 7henotype rt Ah locus
(e . - . antip••r