Environmental and Molecular Mutagenesis - Legacy Tobacco ...

202 1989 EMS Abstracts
Notes important conf.unieta -were identified : age was positively correlated with CA, !IN and
. . ° .-aelayed/proloapediEWl'division in 48 hr culturas, and drug exposure significantly
affected IiUTPWand CA . The different genetic tests were often correlated with each
other . In partic . ,HUTAH was positively correlated with CA (p- .02), MUT'PN with CA,
SCE, and SCH1 , .04, .01 respectively) . On the other hand, SCE and SCMf may
have been negatively correlated (p- .05), and there was no correlation between CA, SCE
and ALN . This suggests that urine mutagenicity may measure the metabolic products of
a genotoxic exposure, but that the types of genetic damage detected by the lymphocyte
tests may vary from subject to subject .
http://legacy.library.ucsf.edu/tid/clb93d00/pdf
MAMMALIAN DNA LIGASE I : THE MOLECULAR DEFECT IN BLOOI,fS SYNDROME
Alan E . Tomidnson, Dena D. Lasko, Ams E . WNia and Tarnas Lirqalt
rnperml Caneer Research Fund, Clare Hall Laborabries, South t,6mms, Herts ., EN6 SLD, U.K.
Mammalian cells contain two clistinct DNA i0ases. The major aclivity In proUteratkp oeNS and therefore prohabfy the enzyme
involved in DNA replioation Is the NOh mdealar weipAt enzyme. DNA Npue I. A 1dOkd brm of frs enzyme has been purilkd b
~ ope~ ~~ thymus and tunan oeos . Theae en:ymes tww been characwised and poytbrol antlbod~e ses talaed apakrot
DNA Ipases from the bede:bphapea T4 and T7, yeasts.J.wevelas andand vaccM4a vkus tonlain conserved
repions of amrw add sequence . Poydonai anbbodes have a t sidue peptlde representing one athese
conserved raqons and these anobot