February 15-18, 2009 Washington State Convention Center Seattle ...

PHARMACOKINETICS OF FLORFENICOL IN CHANNEL CATFISH Ictalurus punctatus
Patricia S. Gaunt,* Christopher Wrzesinski, Cory Langston, Louis Crouch, Rodgers Polk, Dana Gao
and Richard Endris
Mississippi State University
College of Veterinary Medicine
Delta Research and Extension Center
P.O. Box 197
Stoneville, MS 38776 USA
gaunt@cvm.msstate.edu
Enteric septicemia (ESC) and Columnaris disease are the most serious bacterial diseases affecting farm-reared catfish (Ictalurus
punctatus) in the United States. Florfenicol is an antibiotic that was approved for use in catfish in 2005 for control of mortality
associated with ESC and in 2007 was conditionally approved for control of mortality associated with Columnaris disease.
The pharmacokinetics of intravenous and orally administered florfenicol (dose rate: 10 mg/kg once or 10 consecutive days)
were determined for catfish. At various time points ranging from 10 minutes to 36 hours after administration, blood was
sampled from individual fish (6 fish per time point).
The plasma was assayed for florfenicol using an LC-MS/MS method. The pharmacokinetic modeling of the results was performed
using the computer program WinSAAM. Data describing the distribution and elimination of florfenicol in catfish will
be presented.
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