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Table I.19.1:<br />

Association between improved adherence with hand <strong>hygiene</strong> practice and health<br />

care-associated infection rates<br />

Year<br />

1977<br />

Authors<br />

Casewell<br />

& Phillips<br />

Hospital<br />

setting<br />

Adult ICU<br />

1982 Maki & Hecht Adult ICU<br />

1984<br />

Massanari &<br />

Hierholzer<br />

Adult ICU<br />

1989 Conly et al. Adult ICU<br />

1990<br />

1992<br />

Simmons<br />

et al.<br />

Doebbeling<br />

et al.<br />

Adult ICU<br />

Adult ICU<br />

1994 Webster et al. NICU<br />

1995 Zafar et al.<br />

Newborn<br />

nursery<br />

2000 Larson et al. MICU/NICU<br />

2000 Pittet et al. Hospital-wide<br />

2003<br />

2004<br />

MacDonald<br />

et al.<br />

Swoboda<br />

et al.<br />

Hospital-wide<br />

Adult intermediate<br />

care unit<br />

2004 Lam et al. NICU<br />

2004 Won et al. NICU<br />

Significant results<br />

Reduction in Klebsiella spp. health careassociated<br />

infections<br />

Reduction in health care-associated<br />

infection rates<br />

Reduction in health care-associated<br />

infection rates<br />

Reduction in health care-associated<br />

infection rates<br />

No effect (hand <strong>hygiene</strong> improvement<br />

did not reach statistical significance)<br />

Significant difference in health careassociated<br />

infection rates between two<br />

different hand <strong>hygiene</strong> agents<br />

Elimination of MRSA, when combined<br />

with multiple other infection control<br />

measures. Reduction of vancomycin<br />

use<br />

Elimination of MRSA, when combined<br />

with multiple other infection control<br />

measures<br />

Significant (85%) relative reduction of<br />

VRE rate in the intervention hospital; no<br />

significant change in MRSA<br />

Significant reduction in the overall<br />

prevalence of health care-associated<br />

infections and MRSA rates. Active<br />

surveillance cultures and contact precautions<br />

were implemented during the<br />

same time period<br />

Significant reduction in hospitalacquired<br />

MRSA cases<br />

Reduction in health care-associated<br />

infection rates did not reach statistical<br />

significance<br />

No significant reduction in health careassociated<br />

infection rates<br />

Significant reduction of health careassociated<br />

infection rates<br />

Duration of<br />

follow-up<br />

2 years<br />

N.S.<br />

N.S.<br />

N.S.<br />

11 months<br />

8 months<br />

9 months<br />

3.5 years<br />

8 months<br />

5 years<br />

N.S.<br />

2.5 months<br />

6 months<br />

3 years<br />

Ref<br />

67<br />

750<br />

133<br />

504<br />

508<br />

500<br />

119<br />

120<br />

535<br />

262<br />

363<br />

489<br />

531<br />

536<br />

ICU = intensive care unit; NICU = neonatal ICU; MRSA = methicillin-resistant S. aureus;<br />

MICU = medical ICU; N.S. = not stated.

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