ultrasound diagnosis of fatal anomalies

WOLF–HIRSCHHORN SYNDROME
Fig. 9.82 Wolf–Hirschhorn syndrome. Fetal male
genitalia at 32 weeks; both testes are undescended,
andthe penis has an atypical shape due to hypospadias
(courtesy of Dr. Lebek).
Fig. 9.83 Wolf–Hirschhorn syndrome. Atypical
shape of the fetal foot at 32 weeks (courtesy of Dr.
Lebek).
bellar hypoplasia, cleft lip and palate, microgenia,
diaphragmatic hernia, renal anomalies,
cryptorchism, hypospadias.
Differential diagnosis: Cri-du-chat syndrome,
Fryns syndrome, Jacobsen syndrome, triploidy,
trisomy 9, trisomy 18.
Prognosis: The outcome is poor; one-third of the
infants die within the first year of life. Eighty
percent suffer from fits, and in most cases there
is severe restriction in psychomotor development.
The oldest patient was 24 years of age.
Girls are affected in two-thirds of cases.
Self-Help Organization
Title: 4 p Parent Contact Group
Description: Provides support and information
to families only of children with Wolf–
Hirschhorn syndrome. Offers phone support,
biographies of other children with this syndrome.
Newsletter.
Scope: National
Number of groups: One group in the United
Kingdom
Founded: 1984
Address: 1874 NW 108th Ave, Plantation, FL
33322, United States
Telephone: 954–476–9345
E-mail: bbr@juno.com
Web: www.4 p-supportgroup.org
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