ultrasound diagnosis of fatal anomalies

HOLOPROSENCEPHALY
Fig. 2.29Holoprosencephaly. Facial profile. Termination
of pregnancy.
Fig. 2.30 Holoprosencephaly. Frontal aspect. Termination
of pregnancy.
Procedure after birth: Intensive life-saving
measures are not indicated, due to the very poor
prognosis.
Prognosis: Severely affected infants die within
6 months after birth. Less severely affected
children may survive with various degree of
mental impairment.
Self-Help Organization
Title: Holoprosencephaly Self-Help Group,
Berliner Strasse 61a, 63 110 Rodgau, Germany
Telephone: + 49–6106–18888
References
Bernard JP, Drummond CL, Zaarour P, Molho M, Ville Y. A
new clue to the prenatal diagnosis of lobar holoprosencephaly:
the abnormal pathway of the anterior
cerebral artery crawling under the skull. Ultrasound
Obstet Gynecol 2002; 19: 605–7.
Blaas HG, Eriksson AG, Salvesen KA, et al. Brains and
faces in holoprosencephaly: pre- and postnatal description
of 30 cases. Ultrasound Obstet Gynecol
2002; 19: 24–38.
Filly RA, Chinn DH, Callen PW. Alobar holoprosencephaly:
ultrasonographic prenatal diagnosis. Radiology
1984; 151: 455–9.
Gembruch U, Baschat AA, Reusche E, Wallner SJ, Greiwe
M. First-trimester diagnosis of holoprosencephaly
with a Dandy–Walker malformation by transvaginal
ultrasonography. J Ultrasound Med 1995; 14: 619–
22.
Hoffman TJ, Horoupian DS, Koenigsberg M, Schnur MJ,
Llena JF. Lobar holoprosencephaly with hydrocephalus:
antenatal demonstration and differential
diagnosis. J Ultrasound Med 1986; 5: 691–7.
Holzgreve W, Miny P, Gullotta F. Sonographic diagnosis
of holoprosencephaly in the 2nd trimester. Geburtshilfe
Frauenheilkd 1985; 45: 813–4.
Moog U, De Die-Smulders CE, Schrander-Stumpel CT, et
al. Holoprosencephaly: the Maastricht experience.
Genet Couns 2001; 12: 287–98.
Nelson LH, King M. Early diagnosis of holoprosencephaly.
J Ultrasound Med 1992; 11: 57–9.
Tomd P, Costa A, Magnano GM, Cariati M, Lituania M.
Holoprosencephaly: prenatal diagnosis by sonography
and magnetic resonance imaging. Prenat Diagn
1990; 10: 429–36.
Turner CD, Silva S, Jeanty P. Prenatal diagnosis of alobar
holoprosencephaly at 10 weeks of gestation. Ultrasound
Obstet Gynecol 1999; 13: 360–2.
Wong HS, Lam YH, Tang MH, Cheung LW, Ng LK, Yan KW.
First-trimester ultrasound diagnosis of holoprosencephaly:
three case reports. Ultrasound Obstet Gynecol
1999; 13: 356–9.
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