IC1 - Avaliação de Risco Nutricional e Desnutrição em ... - Nutritotal

Materiais e métodos
Prospective, single-centre, placebo-controlled, randomized trial in a university hospital intensive care unit
(ICU). Inclusion criteria: SIRS diagnosis at ICU admission, age> 18, APACHE II score> 15. Exclusion criteria:
pregnancy, chronic renal failure, immune deficiency, coma after cardiopulmonary arrest. Two groups of
patients: Group A: received bolus-loading dose of SeA: 2000mcg (25.3mcmol) over 2 h followed by
continuous infusion (CIV) of 1600 mcg/d (20.24 mcmol) for 10d. Group B: CIV of 0.9% saline solution as
placebo. Clinical outcome was evaluated by the Sepsis Related Organ Failure (SOFA) score. To assess
[GPx-3] and other variables, blood samples were obtained before randomization (day 0), days 3, 7 and 10.
[GPx-3] was measured by an indirect method based on the oxidation of glutathione and expressed as U/mL.
Data are expressed as means ± SD. Differences between groups were assessed using Mann Whitney –U
Test and Chi- square. p value