Contents - Max-Planck-Institut für Physik komplexer Systeme

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|| 2 1 0.8 0.6 0.4 0.2 0 2 4 6 8 10 1 0 0 50 100 150 200 t (fs) 0.95 Figure2: Survivalprobabilityofa2svacancy inNe5H + (solidline)-theexponentialdecay isshownwithadashedline. Theinset(logarithmicscale)showsthedeviationfromtheexponentialdecayatshorttimes. Note,thatfor timesbeyondthatoftheinsetthebeginning motionofthenucleiwillchangethepresentresultswhichisbasedonstaticnuclei. 0.9 Electronic decay in charged environment While thepresenceofasinglechargecanmodifytherate oftheexponentialdecayofacore-ionizedstate, a multiplepositiveenvironmentcandramaticallychange thedecayandevenleadtoanoscillatorybehavior[3]. ThisisduetothefactthattheAugerelectronisnot ejectedintoatruecontinuum,butratherintoamanifoldofshake-upboundstates.Asaconsequence,the outgoingelectronwaveiseventuallyreflectedfrom theeffectivepotentialboundary. Asimilarproblem wasencounteredbyBixonandJortnerinthecontextofnon-radiativedecay[13]andsolvedtherefor amodelproblem.WehavedevelopedanADC-based time-dependentfirst-principlesapproachthatisable topredictthetruedynamicsofelectronicdecayina givenhighlyionizedsystem. ForCoster-Kronigdecayof (2s −1 )Ar + ArinmultiplyionizedAr13cluster, wefindaroughlyexponentialdecayinthebeginning whichiseventuallysuppressedbytheoscillatorywavepacketdynamicsatlatertimes,seeFig.1. Forthe muchslowerexponentialICDinadoublyionizedNe6 cluster,wefindasub-exponentialdecayinthecharged environment(Fig.2). [1] S.Kopelke,K.Gokhberg,L.S.CederbaumandV.Averbukh,J.Chem.Phys.130,144103(2009). [2] V.AverbukhandP.Kolorenč,Phys.Rev.Lett.103,183001(2009). [3] V.Averbukh,U.SaalmannandJ.M.Rost,Phys.Rev.Lett.104,233002(2010). [4] See,e.g.M.A.Kornberg,A.L.Godunov,S.Itza-Ortiz,D.L.Ederer,J.H.McGuireandL.Young,J.SynchrotronRad.9,298(2002). [5] U.SaalmannandJ.M.Rost,Phys.Rev.Lett.89,143401(2002). [6] K.Gokhberg,V.AverbukhandL.S.Cederbaum,J.Chem.Phys.126,154107(2007). [7] R.SantraandL.S.Cederbaum,Phys.Rev.Lett.90,153401(2003). [8] Y.Morishita,X.-J.Liu,N.Saito,T.Lischke,M.Kato,G.Prümper,M.Oura,H.Yamaoka,Y.Tamenori,I.H.Suzuki,Phys.Rev.Lett. 96,243402(2006). [9] P.Kolorenč,V.Averbukh,K.GokhbergandL.S.Cederbaum,J.Chem.Phys.129,244102(2008). [10] V.Averbukh,P.Kolorenč,K.GokhbergandL.S.Cederbaum,ProgressinTheoreticalChemistryandPhysics(Springer),2009,Volume 20,PartII,155-181,ProceedingsofThirteenthInternationalWorkshoponQuantumSystemsChemistryandPhysics,editedbyP. Piecuchetal. [11] V.Averbukh,U.SaalmannandJ.M.Rost,inpreparation. [12] R.Neutze,R.Wouts,D.vanderSpoel,E.WeckertandJ.Hajdu,Nature406,752(2000). [13] M.BixonandJ.Jortner,J.Chem.Phys.48,715(1967). Thephysicsofproteinaggregationphenomena (Dr.ChiuFanLee) Thephysicsofproteinaggregationphenomena Mycurrentmainresearchinterestsconcernthe phenomenaofproteinaggregation,andtheirrelationstohumanpathologyanddevelopmentalbiology. Specifically,Iaminvestigatingtheaggregationphenomenaof(i)proteinamyloids,whicharelinearselfassembledstructureofproteinsthatareintimatelyrelatedtoagreatvarietyofhumandiseasessuchastheAlzheimer’sdiseaseandtypeIIdiabetes,and(ii)Pgranules,whicharegermcellgranulesintheonecellembryooftheroundwormC.elegans. Thesegranulesareinstrumentaltotheproperdevelopment ofthegametesoftheorganism. 104 DetailsandData
Collaborationsatthe mpipks WithprofessorFrankJülicherandhisgraduatestudentJöbinGharakhani, IamemployingthetheoryofphaseseparationinphysicstounderstandhowPgranulesareassembled uponthefertilizationoftheembryo.Specifically,werecentlyfoundthatbycombiningasimplemean-field free-energybasedmodelandtheclassicLifshitz-Slyozovdropletgrowthmodel,wearecapableofexplainingallofthesalientaspectsobservedintheproteinaggregationprocess.Witharangeofexperimental techniquesthatincludefluorescencecorrelationspectroscopy,confocalimagingandthree-dimensional particletracking,wearenowattemptingtoquantitativelyverifythemodel. Toachievethistask,a numberofoutstandingtheoreticalissueshavetobeaddressed. Forinstance,todescribethedynamics oftheaggregationphenomenon,onewillneedtogeneralizetheLifshitz-Slyozovmodelsubstantiallyto allowforsimultaneousdissolutionandcondensationeventsindifferentpartsofthecell.Thesechallenges areofinteresttophysicistsaswellasbiologists. Ourresearchisalsorelevanttootherself-assembled structuresobservedincellssuchasthePbodies,Cajalbodies,andstressgranules. Itisthereforeour ultimategoaltoestablishaquantitativetheorythatcanexplaincollectivelythesediverseintracellular assemblyprocesses. Besidesmymainfocusonproteinaggregationphenomena,Iamalsointerestedinapplyingfarfrom equilibriumtechniquesinphysicstostudybiologicalsystems.Thisapproachisimportantbecausemost biologicalprocesseshappeninthefarfromequilibriumregime.Variousmethodsareavailabletoinvestigatethesenonequilibriumprocesses.Forinstance,Kramersescapetheoryissuitablefortheanalysisof therateofacertainrareeventinafluctuatingsystem.Usingthistheory,Ihaveinvestigatedtherateof uncontrolledcellproliferationinrelationtoskincancer[1].AnotherapproachtostudynonequilibriumsystemsiswiththeuseoftheFokker-Planckequation.Basedonthisformalism,Ihaveemployedbothnaive [2]andrenormalizationgroupimproved[5]perturbativemethodstostudythephenomenonofcollective motioninself-propelledparticles. Furthermore,withDr. FernandoPeruani,Ihaverecentlyinitiateda studyofcollectivemotioninself-propelledparticlesonalatticefromafield-theoreticperspective. Externalcollaborations FortheprojectontheinvestigationofPgranulesformation,myexternal collaboratorsinclude • TheHymangroupattheMaxPlanckInstituteofMolecularCellBiologyandGenetics. • ProfessorCliffordBrangwynneattheDepartmentofChemicalandBiologicalEngineering,PrincetonUniversity. • Dr.ZdenekPetráˇsekattheBiotechnologyCenter(BIOTEC)oftheTechnischeUniversitätDresden. Fortheproteinamyloidproject,IamcollaboratingwiththeVauxgroupattheDunnSchoolofPathology, UniversityofOxford. Externalpresentations Invitedtalks: • C.F.Lee. “Thephysicsofproteinamyloidformation.” DepartmentofPhysicsandAstronomy, UniversityofEdinburgh,August2010. • C.F.Lee.“Proteinaggregationphenomena.”DepartmentofPhysiology,McGillUniversity,November2010. Contributedtalks: • C.F.Lee. “Proteinamyloidself-assembly.” Pierre-GillesdeGennesWinterSchool2010–FEBS AdvancedLectureCourseonCytoskeleton,ContractilityandMotility,February2010 • C.F.Lee.“Proteinamyloidformation:atheoreticalphysicistsview.”DPGSpringMeeting,March 2010 • C.F.Lee,C.P.Brangwynne,Z.Petráˇsek,J.Gharakhani,A.A.Hyman,andF.Jülicher. “Spatial organizationofthecellcytoplasm: Proteingradientsandliquid-liquidphaseseparationintheC. elegansembryo.”DPGSpringmeeting,March2011. PKS-Fellowship 105
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Contents 1 ScientificWorkanditsOrga
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Chapter1 ScientificWorkanditsOrgani
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2009-2010 •In2009Dr.K.Hornbergera
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possibilityforyoungscientiststotake
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manipulationofchargequbits.TakingCo
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Matter wave interference with compl
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interactinggas,futureworkwilladdres
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scalesrangingfromindividualhaircell
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Ohio(Neiman). Problemsfromcellbioph
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oleofdisorderinexoticstronglycorrel
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architectures.Togetherwithdeveloper
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September.Theverysamefoundationsupp
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many-bodyeffectsinquantumdots. Even
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insystemsexhibitingalong-rangeinter
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experimentalprobesleadtoperturbatio
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andefficiency. Theyarethereforewell
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isdefinedbyaslow-downofcelldivision
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1.10 AdvancedStudyGroups AdvancedSt
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AdvancedStudyGroup2010:Quantumtherm
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InJanuaryattentionturnedtocoldatoms
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2.1 Photo Activated Coulomb Complex
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2.2 Molecular bond by internal quan
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2.3 Modular Entanglement in Continu
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2.4 Rotons and Supersolids in Rydbe
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2.5 Electromagnetically Induced Tra
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2.6 Delayed Coupling Theory of Vert
Page 54 and 55: 2.7 Reorientation of Large-Scale Po
Page 56 and 57: 2.8 Coupling Virtual and Real Hair
Page 58 and 59: 2.9 How Stochastic Adaptation Curre
Page 60 and 61: 2.10 Experimental Manifestations of
Page 62 and 63: 2.11 The Statistical Mechanics of Q
Page 64 and 65: 2.12 Entanglement Analysis of Fract
Page 66 and 67: 2.13 Quantum Spin Liquids in the Vi
Page 68 and 69: 2.14 Work Dissipation Along a Non Q
Page 70 and 71: 2.15 Probabilistic Forecasting JOCH
Page 72 and 73: 2.16 Magnetically Driven Supercondu
Page 74 and 75: 2.17 Quantum Criticality out of Equ
Page 76 and 77: 2.18 High-Quality Ion Beams from Na
Page 78 and 79: 2.19 Terahertz Generation by Ionizi
Page 80 and 81: 2.20 Many-body effects in mesoscopi
Page 82 and 83: Bone is a complex tissue that is be
Page 84 and 85: Cooperation is a central phenomenon
Page 86 and 87: 2.23 Measuring the Complete Force F
Page 88 and 89: 2.24 Pattern Formation in Active Fl
Page 90 and 91: 2.25 Magnon Pairing in a Quantum Sp
Page 92 and 93: 2.26 Shortcuts to Adiabaticity in Q
Page 94 and 95: 2.27 Itinerant Magnetism in Iron Ba
Page 96 and 97: 2.28 Kinetochores are Captured by M
Page 98 and 99: Chapter3 DetailsandData 3.1 PhDProg
Page 100 and 101: IMPRSmeetinginBadSchandau(Sächsich
Page 102 and 103: thephysicsofcomplexsystems.In2009we
Page 106 and 107: • C.F.Lee,L.Jean,C.Lee,M.Shaw,and
Page 108 and 109: Externalcollaborations WithA.Chubuk
Page 110 and 111: continuousspectrum)attheedgeoftheKA
Page 112 and 113: • Non-centrosymmetricsuperconduct
Page 114 and 115: 20. TCS-PROGRAM:SynchronizationandM
Page 116 and 117: 3.3.7 WorkshopParticipationandDisse
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Page 120 and 121: Longhi,Malpuech,Peschel,Ruo)andphot
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Page 124 and 125: Scientificresults: Thestatementthat
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Page 132 and 133: moreexperiencedresearchesasthesewer
Page 134 and 135: Forthismeeting,wedecidedtochoosetwo
Page 136 and 137: Summary. Theworkshopcollectedandatt
Page 138 and 139: mpipks colloquium given by S. Ospel
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Page 142 and 143: climatedata.Finally,PeterTalknerdem
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Page 146 and 147: 3.4.3 AdditionalExternalFunding •
Page 148 and 149: 3.5.2 Degrees Habilitations • Lin
Page 150 and 151: 3.6 PublicRelations 3.6.1 LongNight
Page 152 and 153: 3.7 BudgetoftheInstitute Thefollowi
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52% 56% 13% 11% Budgetforpersonnel
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In 2010 a large parallel cluster wa
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Gugliandolo,L. ProfessorDr. Laborat
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Orosz,H. Oberbürgermeisterinder La
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Chapter4 Publications 4.1 Light-Mat
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Taya,S.A.,M.M.ShabatandH.M.Khalil:
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Oh,S.: Geometricphasesandentangleme
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Stoyanova,A.,L.Hozoi,P.FuldeandH.St
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Thielemann,B.,C.Rüegg,H.M.Rønnow,
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2010 Charrier,D.andF.Alet:Phasediag
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Gvozdikov, V.M.: Compositefermionsw
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Lindner,B.,D.Gangloff,A.LongtinandJ
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Denisov,S.I.,W.HorsthemkeandP.Häng
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Gogberashvili, M.andR.Khomeriki: Tr
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Wang,Q.J.,C.Yan,L.Diehl,M.Hentschel
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Contents - Max-Planck-Institut für Physik komplexer Systeme

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