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CYTOKINE SIGNALING 4
Cytokine and Related Genes
Cytokines are key modulators of the immune system. They are produced mainly by T lymphocytes in response to infectious agents. Some
cytokines induce the inflammatory response or stimulate B cells to produce antibodies while others act to offset these effects by
downregulation. InvivoGen offers a comprehensive list of cytokine genes classified in different families including interleukins and chemokines.
Description
Cytokine and related genes are provided either in a pORF or a pUNO
plasmid (see page 37), both containing the complete coding sequence from
the ATG to the Stop codon. Each gene is fully sequenced.
Gene families in pORF plasmids:
- Chemokine genes - Immune receptor genes
- Chemokine receptor genes - Interferon genes
- Cytokine genes - Interleukin genes
- Cytokine suppressor genes - Interleukin receptor genes
Gene family in pUNO plasmids:
- Interferon signaling genes
Contents and Storage
Each pORF and pUNO plasmid is provided as a lyophilized transformed
E. coli strain on a paper disk. Transformed strains are shipped at room
temperature and should be stored at -20°C.
Each pORF is provided with 4 pouches of E. coli Fast-Media ® Amp (2 TB
and 2 Agar) and each pUNO plasmid with 4 pouches of E. coli
Fast-Media ® Blas (see pages 44-45).
PRODUCT QUANTITY CAT. CODE*
pORF- E. coli disk porf-
pUNO- E. coli disk puno-
* Catalog codes are available on our website
Anti-Cytokine Neutralizing IgA Antibodies
Description
Neutralizing IgA antibodies are chimeric monoclonal antibodies in which
the constant domains of the human IgA molecule were combined with
murine variable regions. They have been selected for their ability to
efficiently neutralize the biological activity of selected cytokines. The
neutralizing activity of these IgA antibodies was determined using
InvivoGen’s HEK-Blue Cytokine Cells.
Contents and Storage
Each neutralizing IgA antibody is provided lyophilized from a 0.2 μm
filtered solution in PBS. Product should be reconstituted in sterile water.
Lyophilized antibodies are stable greater than six months when stored
at -20ºC. Reconstituted IgAs are stable 1 month when stored at 4ºC and
6 months when aliquoted and stored at -20ºC.
PRODUCT ANTIGEN REACTIVITY QUANTITY
CATALOG
CODE
Anti-hCD40L-IgA2 Human CD40 ligand Human 100 μg maba-h40l
Anti-hIFNa-IgA2 Human Interferon a Human 100 μg maba-hifna
Anti-hIFNg-IgA2 Human Interferon g Human 100 μg maba-hifng
Anti-hIL-1b-IgA2 Human Interleukin 1b Human 100 μg maba-hil1b
Anti-hIL-4-IgA2 Human Interleukin 4 Human 100 μg maba-hil4
Anti-hIL-6-IgA2 Human Interleukin 6 Human 100 μg maba-hil6
Anti-hIL-13-IgA2 Human Interleukin 13 Human 100 μg maba-hil13
Anti-hIL-18-IgA2 Human Interleukin 18 Human 100 μg maba-hil18
Anti-hTGFb-IgA2 Human Tumor Growth Factor b Human 100 μg maba-htgfb
Anti-hTNFa-IgA2 Human Tumor Necrosis Factor a Human 100 μg htnfa-mab7
104 www.invivogen.com/cytokine-signaling