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pUNO pUNO-HA Toll-Like Receptors (TLRs) pDUO pZERO/pDeNy TLR1 h, m, p h, m h, m h, m h, m TLR2 h, m, p, b h, m h, m h, m h, m TLR3 h, m h, m - h, m h, m TLR4 h, m h, m h, m h, m h, m TLR5 h, m, p, b h, m - h, m h, m TLR6 h, m, p, b h, m h, m h, m h, m TLR7 h, m, p, b h, m - h, m h, m TLR8 h, m h, m - h, m h, m TLR9 h, m, p, b h, m - h, m h, m TLR10 h, p h - h h TLR11 m - - - - TLR11/12 m m - - - TLR13 m - - - - NOD-Like Receptors (NLRs) IPAF / CARD12 h - - - - NAIP5 / BIRC1E m - - - - NALP1 h - - - - NALP2 h - - - - NALP3 / NLRP3 h - - - - NALP12 / Monarch-1 h - - - - NOD1 / CARD4 h, m - - h - NOD2 / CARD15 h, m - - h - NOD9 / NLRX1 h, m - - - RIG-I-Like Receptors (RLRs) LGP2 h, m - - - - MDA-5 h - - - - RIG-I / DDX58 h, m - - h - Other Pathogen Sensors AIM2 / IFI210 h, m - - - - CLEC9A h - - - - DAI / ZBP h, m - - - - DC-SIGN / CD209 h, m - - - - Dectin-1 h, m - - - - IFI16 h, m - - - - L-SIGN h - - - - MBL1, 2 h, m - - - - Mincle / CLEC4E h, m - - - - PGRP-L, -S, -Ia h, m - - - - SIGNR1, 2, 3, 4 Adaptors m - - - - ASC / PYCARD / CARD5 h, m - - - - Cardinal / CARD8 h - - - - IPS1 / MAVS / VISA h, m - - - - MyD88 h, m - - h, m - RAC1 m - - - - SARM1 h, m - - - - TIRAP / Mal h, m - - h - TRAM / TICAM2 h, m - - h - TRIF / TICAM1 Co-receptors h, m - - h - CD14 h, m - h, m - - sCD14 (soluble) h - - - - CD36 h, m - - - - LBP h, m - - - - MD2 / Ly96 h, m - h, m - - PRAT4A, 4B h, m - - - - pZERO-TLR-HA Signaling Effectors www.invivogen.com/innate-immunity pUNO pUNO-HA pDUO pZERO/pDeNy BCL10 / CLAP h, m - - - - CARD9 h, m - - - - DDX3 m - - - - FADD / MORT1 h, m - - - - IKKa, b h, m - - - - IKKε h, m - - - - IRAK-1, -4 h, m - - - - ITCH h, m - - - - MAPK1 h - - - - MAPK2 h, m - - - - NAP1 / AZI2 h, m - - - - NEMO / IKKg h, m - - - - Pellino1, 2, 3 h, m - - - - PRKD1 h - - - - PKR h, m - - h - PRKRA / PACT h, m - - - - RIP1 / RIPK1 h, m - - - - RIP2 / RIPK2 h, m - - - - RIP3 / RIPK3 h, m - - - - STING h, m - - - - SUGT1 h, m - - - - Syk h, m - - - - TAB1, 2, 3 h - - - - TAK1 / MAP3K7 h, m - - - - TANK h, m - - - - TBK1 h, m - - - - TIFA h, m - - - - TRADD h, m - - - - TRAF3 h, m - - - - TRAF6 h, m - - - - UNC93B1 h, m - - - - Signaling Inhibitors ABIN1, 2, 3 h, m - - - - ATF3 h, m - - - - AXL / UFO h, m - - - - Bcl-3 h, m - - - - DAK h, m - - - - DUBA / OTUD5 m - - - - FLII / Fliih h, m - - - - IRAK-M h, m - - - - MD-1 h, m - h, m - - MFN2 h, m - - - - MULAN / Dublin h, m - - - - PIN1 / DOB h, m - - - - PPP3CA, CB h, m - - - - PPP3R1 h, m RNF125 / TRAC-1 h, m - - - - RP105 h, m - h, m - - SHP-1 / PTPN6 h, m - - - - SIGIRR / TIR8 h, m - - - - SIKE h, m - - - - T1 / ST2 / IL1RL1 h - - - - TNFAIP3 / A20 h, m - - - - Tollip / IL-1RAcPIP h, m - - - - TRAFD1 / FLN29 h, m - - - - TRIAD3A h, m - - - - Tyro3 / BYK h, m - - - - pZERO-TLR-HA 57 INNATE IMMUNITY 3
INNATE IMMUNITY 3 pUNO - Native Genes Features and Benefits Numerous genes encoding pattern recognition receptors (PRRs), co-receptors, adaptors, signaling effectors and signaling inhibitors are available in the pUNO plasmid. The genes are cloned from the ATG to the Stop codon, excluding introns and untranslated regions. All genes are fully sequenced, the sequences are available online at www.invivogen.com or can be emailed upon request. PRR and related genes are cloned under the control of the strong and ubiquitous mammalian promoter, EF1a/HTLV. This composite promoter is comprised of the elongation factor 1 alpha (EF-1a) core promoter and the R-U5’ of the human T cell leukemia virus (HTLV). pUNO plasmids can be used directly for in vitro or in vivo transfection experiments. They are selectable with blasticidin in both E. coli and mammalian cells. To facilitate the excision and subcloning of the gene of interest into another vector, each gene is flanked by unique restriction sites that are compatible with many others. Some genes are provided in the pUNO2 (Zeocin -resistant) or pUNO3 (hygromycinresistant) backbone Contents and Storage Each pUNO plasmid is provided as a lyophilized transformed E. coli strain on a paper disk. Transformed strains are shipped at room temperature and should be stored at -20ºC. Lyophilized E. coli cells are stable for at least 1 year when properly stored. Each plasmid is provided with 4 pouches of E. coli Fast-Media ® Blas (2 TB and 2 Agar). 58 Toll-Like Receptors (TLRs) TLR genes from different species are available: - human - mouse - pig - bovine Human TLR genes are available in two different plasmid backbones: - pUNO/pUNO1 selectable with blasticidin - pUNO3, selectable with hygromycin GENE NAME DESCRIPTION TOLL-Like Receptors (TLRs) CAT. CODE (human) CAT. CODE (human, hygro) CAT. CODE (mouse) TLR1 Toll-like Receptor 1 puno-htlr1 puno3-htlr1 puno-mtlr1 puno1-ptlr1 NEW - TLR2 Toll-like Receptor 2 puno-htlr2 puno3-htlr2 puno-mtlr2 puno1-ptlr2 NEW puno1-btlr2 NEW TLR3 Toll-like Receptor 3 puno-htlr3 puno3-htlr3 puno-mtlr3 - TLR4 Toll-like Receptor 4 puno1-htlr4a puno3-htlr4a puno-mtlr4 - TLR5 Toll-like Receptor 5 puno-htlr5 puno3-htlr5 puno-mtlr5 puno1-ptlr5 NEW puno1-btlr5 NEW TLR6 Toll-like Receptor 6 puno-htlr6 puno3-htlr6 puno-mtlr6 puno1-ptlr6 NEW puno1-btlr6 NEW TLR7 Toll-like Receptor 7 puno-htlr7 puno3-htlr7 puno-mtlr7 puno1-ptlr7 NEW puno1-btlr7 NEW TLR8 Toll-like Receptor 8 puno1-htlr8b puno3-htlr8b puno-mtlr8 - TLR9 Toll-like Receptor 9 puno1-htlr9a puno3-htlr9a puno-mtlr9 puno1-ptlr9 NEW puno1-btlr9 NEW TLR10 Toll-like Receptor 10 puno-htlr10 puno3-htlr10 - puno1-ptlr10 NEW TLR11 Toll-like Receptor 11 - - puno-mtlr11t - TLR11/12 Toll-like Receptor 11/12 - - puno-mtlr11z - TLR13 Toll-like Receptor 13 - - puno-mtlr13 - www.invivogen.com/innate-immunity-puno Related Products Blasticidin, page 17 Hygromycin B, HygroGold , page 18 Fast-Media ® Blas, page 45 Fast-Media ® Hygro, page 45 CAT. CODE (pig) CAT. CODE (bovine)
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INNOVATION WITHIN REACH InvivoGen
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CONTENTS AT A GLANCE 1 CELL CULTURE
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4 CYTOKINE SIGNALING TABLE of CONTE
Page 8 and 9: Mycoplasma Detection & Elimination
Page 10 and 11: PlasmoTest Contents - HEK-Blue -2
Page 12 and 13: Primocin - The Antimicrobial Shiel
Page 14 and 15: SEAP Reporter Gene System Secreted
Page 16 and 17: HEK-Blue Detection - Real-Time Det
Page 18 and 19: Blasticidin S Description Blasticid
Page 20 and 21: LyoVec New formulation LyoVec is
Page 22 and 23: Poly-Arginine-HA Tagged Reprogrammi
Page 24 and 25: LENTI-Smart - Lentiviral Vector Pr
Page 26 and 27: Lentiviral Vector Production and Ce
Page 28 and 29: Antibody generation using pFUSE-CHI
Page 30 and 31: Engineering Fc regions for altered
Page 32 and 33: pBROAD & pWHERE - Optimized Vector
Page 34 and 35: pSELECT-Tag - Expression of a GFP-,
Page 36 and 37: pVIVO - Expression of Two Genes of
Page 38 and 39: pORF Description pORF plasmids feat
Page 40 and 41: Prom A-List - Human and Rodent Pro
Page 42 and 43: PROMOTER GENE TISSUE DISTRIBUTION S
Page 44 and 45: ChemiComp E. coli ChemiComp E. coli
Page 46 and 47: Fast-Media ® Preparation 1. Empty
Page 48 and 49: RIG-I-like Receptors 54 RLR & RLR-R
Page 50 and 51: Toll-Like Receptors Toll-Like Recep
Page 52 and 53: www.invivogen.com/innate-immunity 5
Page 54 and 55: IPAF and NAIP5 IPAF (NLRC4, CLAN/CA
Page 56 and 57: C-Type Lectin Receptors C-type lect
Page 60 and 61: GENE NAME/ALIASES DESCRIPTION CAT.
Page 62 and 63: pDUO - Gene Associations Features a
Page 64 and 65: pZERO-TLR & pDeNy - Dominant Negati
Page 66 and 67: 293/TLR & 293/NOD Clones 293/TLR Cl
Page 68 and 69: Response of HEK-Blue hTLR2 cells t
Page 70 and 71: Ramos-Blue Cells - NF-kB/AP-1 Repo
Page 72 and 73: MEF Cells C3H/TLR4mut & C3H/WT MEFs
Page 74 and 75: Antibodies for Detection ANTIBODY D
Page 76 and 77: - NF-kB binding site: Nuclear facto
Page 78 and 79: PRODUCT ORIGIN/DESCRIPTION TLR2 Ago
Page 80 and 81: PRODUCT ORIGIN/DESCRIPTION TLR9 Ago
Page 82 and 83: PRODUCT ORIGIN/DESCRIPTION Dectin-1
Page 84 and 85: LPS-PG (Porphyromonas gingivalis) R
Page 86 and 87: • FLA-ST ultrapure was purified b
Page 88 and 89: 1. Zhao H. et al., 2004. Contributi
Page 90 and 91: 1. Hornung V. et al., 2006. 5'-Trip
Page 92 and 93: TLR/NOD Ligand Screening InvivoGen
Page 94 and 95: Signal Transduction Inhibitors Invi
Page 96 and 97: Pepinh-MYD - MyD88 inhibitory pepti
Page 98 and 99: 1. Martinon F,. et al., 2002. The i
Page 100 and 101: Nigericin - NLRP3 Inflammasome Indu
Page 102 and 103: Autophagy is a pathway by which cyt
Page 104 and 105: 4 CYTOKINE SIGNALING Cytokine Genes
Page 106 and 107: Blue Cytokine Reporter Cells Blue
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HEK-Blue IFN-a/b Cells - Human Typ
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HEK-Blue IL-6 Cells - IL6 Reporter
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HEK-Blue IL-1b Cells - IL-1b Repor
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HEK-Blue IL-33/IL-1b Cells - IL-33
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HEK-Blue CD40L Cells - CD40L Repor
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5 ANTIBODIES & VACCINATION Antibodi
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Antibody generation using pFUSE-CHI
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Immunoglobulin A The mucosal surfac
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IgA Detection and Quantification In
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IgG Antibodies InvivoGen offers a s
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Mediators? 1. Leroux-Roels G., 2010
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Poly(I:C) Synthetic double-stranded
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pVAC - Induction of Neutralizing An
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CpG-Free DNA CpGs and the Immune Re
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pCpGfree-basic & pCpGfree-promoter
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pCpGfree-siRNA & pCpGfree-siRNADUO
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Custom-Made CpG-Free Genes InvivoGe
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RNA INTERFERENCE 7 psiRNA System I
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RNA INTERFERENCE 7 psiRNA-h7SK - 7S
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RNA INTERFERENCE 7 psiTEST System
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RNA INTERFERENCE 7 Ready-Made psiRN
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RNA INTERFERENCE 7 Custom-Made psiR
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INHIBITORS 8 Inhibitors PRODUCT DES
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INHIBITORS 8 Pattern Recognition Re
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INHIBITORS 8 Triptolide - NF-kB Inh
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INHIBITORS 8 Heat Shock Protein Inh
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9 CUSTOM SERVICES TLR/NOD Ligand Sc
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CUSTOM SERVICES 9 Custom Cloning :
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CUSTOM SERVICES 9 Prices 164 TERMS
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166 PRODUCT (QUANTITY) CAT. CODE PA
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A 17-AAG 17-AAGH2 17-AEP-GA 2-Amino
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- ODN 4084-F - ODN INH-1 - ODN INH-
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