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8 INHIBITORS Cytokine Receptor Inhibitor 155 DNA Synthesis Inhibitors 159 Epigenetic Inhibitors 157 Heat Shock Protein Inhibitors 158 Ion Channel Inhibitors 155 Nuclear Export Inhibitor 155 MAPK Inhibitors 156 NF-kB Activation Inhibitors 155 Protein Kinase Inhibitors 157 PRR Signaling Inhibitors 154
INHIBITORS 8 Inhibitors PRODUCT DESCRIPTION Pattern Recognition Receptor (PRR) Signaling Inhibitors BX795 TBK1/IKKε and PDK1 inhibitor 10 nM - 1 μM 5 mg tlrl-bx7 p 154 Chloroquine Endosomal acidification inhibitor 10 μM 250 mg tlrl-chq p 154 CLI-095 TLR4 signaling inhibitor 50 nM - 1 μM 1 mg tlrl-cli95 p 154 Cyclosporin A NEW Calcineurin inhibitor 50 nM - 1.5 μM 100 mg tlrl-cyca p 154 Gefitinib (Iressa) NEW RIP2 tyrosine kinase inhibitor 10 μM 10 mg tlrl-gef p 154 OxPAPC TLR2 and TLR4 inhibitor 30 μg/ml 1 mg tlrl-oxp1 p 154 Pepinh-MYD MyD88 inhibitory peptide 5 - 100 μM 2 mg tlrl-pimyd p 154 Pepinh-TRIF TRIF inhibitory peptide 5 - 100 μM 2 mg tlrl-pitrif p 154 Polymyxin B LPS-induced TLR4 activation inhibitor 10 μg/ml 100 mg tlrl-pmb p 154 Rapamycin (Sirolimus) mTOR inhibitor 10-100 nM 5 mg tlrl-rap p 154 Z-VAD-FMK Pan-caspase Inhibitor 10 μg/ml (20 μM) 1 mg tlrl-vad p 154 Cytokine Receptor Inhibitor SB431542 TGF-b receptor inhibitor 2 μM 5 mg inh-sb43 p 155 Ion Channel Inhibitors Bafilomycin A1 V-ATPase inhibitor 0.1 - 1 μM 10 μg tlrl-baf p 155 Glybenclamide (glyburide) ATP-dependent K+ channel inhibitor 25 μg/ml 1 g tlrl-gly p 155 Nuclear Export Inhibitor WORKING CONCENTRATION QUANTITY CATALOG CODE Leptomycin B NEW Nuclear export inhibitor 50 - 200 nM 5 μg tlrl-lep p 155 NF-kB Activation Inhibitors Bay11-7082 IkB-a inhibitor 1 - 10 μM 10 mg tlrl-b82 p 155 Celastrol NF-kB inhibitor 2.5 - 10 μM 1 mg ant-cls p 155 Triptolide NF-kB activation inhibitor 10 - 100 nM 1 mg ant-tpl p 156 Mitogen-Activated Protein (MAP) Kinase Inhibitors PD98059 MAP kinase kinase inhibitor 50 - 100 μM 10 mg tlrl-pd98 p 156 PD0325901 MEK inhibitor 0.5 μM 2 mg inh-pd32 p 156 SB203580 p38 MAP kinase inhibitor 1 - 20 μM 5 mg tlrl-sb20 p 156 SP600125 JNK inhibitor 10 - 500 μM 10 mg tlrl-sp60 p 156 U0126 MEK1-MEK2 inhibitor 10 - 50 μM 5 mg tlrl-u0126 p 156 Phosphatidylinositol 3-Kinase Inhibitors 3-Methyladenine PI3K inhibitor 5 mM 50 mg tlrl-3ma p 156 LY294002 PI3K inhibitor 50 - 100 μM 5 mg tlrl-ly29 p 156 Wortmannin PI3K inhibitor 0.1 - 2.5 μM 5 mg tlrl-wtm p 156 152 www.invivogen.com/inhibitors INFO
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INNOVATION WITHIN REACH InvivoGen
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CONTENTS AT A GLANCE 1 CELL CULTURE
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4 CYTOKINE SIGNALING TABLE of CONTE
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Mycoplasma Detection & Elimination
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PlasmoTest Contents - HEK-Blue -2
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Primocin - The Antimicrobial Shiel
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SEAP Reporter Gene System Secreted
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HEK-Blue Detection - Real-Time Det
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Blasticidin S Description Blasticid
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LyoVec New formulation LyoVec is
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Poly-Arginine-HA Tagged Reprogrammi
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LENTI-Smart - Lentiviral Vector Pr
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Lentiviral Vector Production and Ce
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Antibody generation using pFUSE-CHI
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Engineering Fc regions for altered
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pBROAD & pWHERE - Optimized Vector
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pSELECT-Tag - Expression of a GFP-,
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pVIVO - Expression of Two Genes of
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pORF Description pORF plasmids feat
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Prom A-List - Human and Rodent Pro
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PROMOTER GENE TISSUE DISTRIBUTION S
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ChemiComp E. coli ChemiComp E. coli
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Fast-Media ® Preparation 1. Empty
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RIG-I-like Receptors 54 RLR & RLR-R
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Toll-Like Receptors Toll-Like Recep
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www.invivogen.com/innate-immunity 5
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IPAF and NAIP5 IPAF (NLRC4, CLAN/CA
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C-Type Lectin Receptors C-type lect
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pUNO pUNO-HA Toll-Like Receptors (T
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GENE NAME/ALIASES DESCRIPTION CAT.
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pDUO - Gene Associations Features a
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pZERO-TLR & pDeNy - Dominant Negati
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293/TLR & 293/NOD Clones 293/TLR Cl
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Response of HEK-Blue hTLR2 cells t
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Ramos-Blue Cells - NF-kB/AP-1 Repo
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MEF Cells C3H/TLR4mut & C3H/WT MEFs
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Antibodies for Detection ANTIBODY D
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- NF-kB binding site: Nuclear facto
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PRODUCT ORIGIN/DESCRIPTION TLR2 Ago
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PRODUCT ORIGIN/DESCRIPTION TLR9 Ago
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PRODUCT ORIGIN/DESCRIPTION Dectin-1
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LPS-PG (Porphyromonas gingivalis) R
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• FLA-ST ultrapure was purified b
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1. Zhao H. et al., 2004. Contributi
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1. Hornung V. et al., 2006. 5'-Trip
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TLR/NOD Ligand Screening InvivoGen
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Signal Transduction Inhibitors Invi
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Pepinh-MYD - MyD88 inhibitory pepti
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1. Martinon F,. et al., 2002. The i
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Nigericin - NLRP3 Inflammasome Indu
Page 102 and 103: Autophagy is a pathway by which cyt
Page 104 and 105: 4 CYTOKINE SIGNALING Cytokine Genes
Page 106 and 107: Blue Cytokine Reporter Cells Blue
Page 108 and 109: HEK-Blue IFN-a/b Cells - Human Typ
Page 110 and 111: HEK-Blue IL-6 Cells - IL6 Reporter
Page 112 and 113: HEK-Blue IL-1b Cells - IL-1b Repor
Page 114 and 115: HEK-Blue IL-33/IL-1b Cells - IL-33
Page 116 and 117: HEK-Blue CD40L Cells - CD40L Repor
Page 118 and 119: 5 ANTIBODIES & VACCINATION Antibodi
Page 120 and 121: Antibody generation using pFUSE-CHI
Page 122 and 123: Immunoglobulin A The mucosal surfac
Page 124 and 125: IgA Detection and Quantification In
Page 126 and 127: IgG Antibodies InvivoGen offers a s
Page 128 and 129: Mediators? 1. Leroux-Roels G., 2010
Page 130 and 131: Poly(I:C) Synthetic double-stranded
Page 132 and 133: pVAC - Induction of Neutralizing An
Page 134 and 135: CpG-Free DNA CpGs and the Immune Re
Page 136 and 137: pCpGfree-basic & pCpGfree-promoter
Page 138 and 139: pCpGfree-siRNA & pCpGfree-siRNADUO
Page 140 and 141: Custom-Made CpG-Free Genes InvivoGe
Page 143 and 144: RNA INTERFERENCE 7 psiRNA System I
Page 145 and 146: RNA INTERFERENCE 7 psiRNA-h7SK - 7S
Page 147 and 148: RNA INTERFERENCE 7 psiTEST System
Page 149 and 150: RNA INTERFERENCE 7 Ready-Made psiRN
Page 151: RNA INTERFERENCE 7 Custom-Made psiR
Page 155 and 156: INHIBITORS 8 Pattern Recognition Re
Page 157 and 158: INHIBITORS 8 Triptolide - NF-kB Inh
Page 159 and 160: INHIBITORS 8 Heat Shock Protein Inh
Page 161 and 162: 9 CUSTOM SERVICES TLR/NOD Ligand Sc
Page 163 and 164: CUSTOM SERVICES 9 Custom Cloning :
Page 165 and 166: CUSTOM SERVICES 9 Prices 164 TERMS
Page 167 and 168: 166 PRODUCT (QUANTITY) CAT. CODE PA
Page 173 and 174: A 17-AAG 17-AAGH2 17-AEP-GA 2-Amino
Page 175 and 176: - ODN 4084-F - ODN INH-1 - ODN INH-
Page 177 and 178: ARGENTINA Genbiotech S.R.L. Tel: +5
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