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INNATE IMMUNITY 3
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GENE NAME/ALIASES DESCRIPTION CAT. CODE (HUMAN) CAT. CODE (MOUSE)
Signaling Effectors
ITCH NEW p38 and JNK activator and NF-kB inhibitor puno1-hitch puno1-mitch
MAPK1 NEW p38 and JNK activator puno1-hmapk1 -
MAPK2 NEW p38 and JNK activator puno1-hmapk2 puno1-mmapk2
NAP1 / AZI2 Regulatory subunit of TBK1/IKKε puno-hnap1 puno-mnap1
NEMO / IKKg Regulatory subunit of IKK complex puno-hnemo puno-mnemo
Pellino1 Co-factor of IL-1-mediated signaling puno-hpeli1 puno-mpeli1
Pellino2 Modulator of IL-1 and LPS signaling puno-hpeli2 puno-mpeli2
Pellino3 Promoter of c-Jun and Elk-1 activation puno-hpeli3a -
PKD1 / PKRD Protein kinase D1 puno1-hprkd1 -
PKR Mediator in dsRNA-induced TLR3 and LPS-induced TLR4 signaling puno-hpkr puno-mpkr
PRKRA / PACT Modulator of PKR activity puno-hprkra puno-mprkra
RIP1 / RIPK1 Mediator of TLR3-induced NF-kB activation puno-hripk1 puno-mripk1
RIP2 / RIPK2 Signal transducer for TLRs and NODs puno-hrick puno-mrick
RIP3 / RIPK3 Modulator of NF-kB activation puno-hripk3 puno-mripk3
STING NEW Stimulator of interferon genes puno1-hsting puno1-msting
SUGT1 NEW Regulator of NOD1 activation puno1-hsugt1b puno1-msugt1
Syk Mitochondrial PRR modulator puno1-hsyk puno1-msyk
TAB1, 2, 3 TAK1 binding proteins 1, 2 ,3 - Mediators of NF-kB activation puno-htab1/2a/3 -
TAK1 / MAP3K7 Modulator of TLR3/TLR4-mediated NF-kB and AP-1 activation puno-hmap3k7b puno-mmap3k7b
TANK Mediator of RLR- and TLR-induced IFN production puno1-htank puno1-mtank
TBK1 Mediator of RLR- and TLR-induced IFN production puno-htbk1 puno-mtbk1
TIFA Mediator of TRAF6/IRAK1 complexes puno-htifa puno-mtifa
TRADD TNF-R1-Associated via Death Domain puno1-htradd puno1-mtradd
TRAF3 Mediator of TBK1 signaling puno-htraf3 puno-mtraf3
TRAF6 Key signal transducer of TLR pathways puno-htraf6 puno-mtraf6
UNC93B1 Multitransmembrane endoplasmic reticulum protein puno1-hunc93b1 puno1-munc93b1
Signaling Inhibitors
ABIN1, 2, 3 A20-associating protein inhibitor of NF-kB puno1-htnip1a/2a/3 puno1-mtnip1a/2/3
ATF3 Negative regulator of TLR signaling puno-hatf3 puno-matf3
AXL / UFO Negative regulator of TLR signaling puno1-haxl puno1-maxl
BCL3 Inhibitor of NF-kB p50 ubiquitination puno1-hbcl3 puno1-mbcl3
DAK Negative regulator of MDA-5 puno1-hdak puno1-mdak
DUBA / OTUD5 TRAF3 inhibitor - puno1-motud5
FLII / Fliih TLR4/MyD88 signaling complex inhibitor puno-hflii puno-mflii
IRAK-M Inhibitor of IRAK-1/TRAF6 complexes puno-hirakm puno-mirakm
MD1 RP105 co-receptor and inhibitor TLR4/MD2 complex puno-h md1 puno-m md1
MFN2 NEW IPS-1 inhibitor puno1-hmfn2 puno1-mmfn2
MULAN/ Dublin Inhibitor of RIG-I/MDA-5 signaling puno1-hmul1 puno1-mmul1
PIN1 / DOB IRF3 inhibitor puno-hpin1 puno-mpin1
PPP3CA NEW MyD88 and TRIF inhibitor - Calcineurin A (NFAT pathway) puno1-hppp3cab puno1-mppp3ca
PPP3CB NEW MyD88 and TRIF inhibitor - Calcineurin B (NFAT pathway) puno1-hppp3cb puno1-mppp3cb
PPP3R1 NEW MyD88 and TRIF inhibitor puno1-hppp3r1 puno1-mppp3r1
RNF125 / TRAC-1 Inhibitor of RIG-I signaling puno1-hrnf125 puno1-mrnf125
RP105 Inhibitor TLR4/MD2 complex puno-hrp105 puno-mrp105
SHP-1 / PTPN6 Negative regulator of TLR signaling puno1-hptpn6 puno1-mptpn6
SIGIRR / TIR8 Negative regulator of TLR/IL-1R signaling puno-hsigirr puno-msigirr
SIKE Physiological repressor of IKKε and TBK1 puno1-hsike puno1-msike
T1 / ST2 / IL1RL1 Negative regulator of IL-1R and TLR2, 4, 9 signaling puno-hil1rl1b -
TNFAIP3 / A20 Inhibitor of TLR and RLR-induced NF-kB activation puno-htnfaip3 puno-mtnfaip3
Tollip / IL-1RAcPIP Inhibitor of NF-kB activation induced by IL-1R, TLR2 and TLR4 puno-htollip puno-mtollip
TRAFD1 / FLN29 Inhibitor of LPS-induced TRAF6 function puno-htrafd1 puno1-mtrafd1
TRIAD3A Negative regulator of TIRAP, TRIF and RIP1 puno-htriad3a puno-mtriad3a
Tyro3 / BYK Negative regulator of TLR signaling puno1-htyro3 puno1-mtyro3
www.invivogen.com/innate-immunity-puno