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Antibodies for Detection ANTIBODY DESCRIPTION SPECIFICITY APPLICATIONS* QTY CAT. CODE Anti-Flagellin Anti-Flagellin FliC Monoclonal mouse IgG1 S. typhimurium flagellin WB 100 μg mabg-flic Anti-TLR1 MAb-hTLR1 Monoclonal mouse IgG1 (GD2.F4) Human TLR1 FC 100 μg mab-htlr1 MAb-hTLR1-FITC Monoclonal mouse IgG1 (GD2.F4), FITC Human TLR1 FC 100 μg mab-htlr1f Anti-TLR2 MAb-hTLR2 Monoclonal mouse IgG2a (TL2.1) Human TLR2 FC, IHC, WB 100 μg mab-htlr2 MAb-hTLR2-FITC Monoclonal mouse IgG2a (TL2.1), FITC Human TLR2 FC, IHC 100 μg mab-htlr2f MAb-mTLR2-FITC Monoclonal mouse IgG1 (T2.5), FITC Human/mouse TLR2 FC 100 μg mab-mtlr2f Anti-TLR3 Anti-hTLR3-IgA Monoclonal human IgA2 Human TLR3 FC 100 μg maba-htlr3 MAb-hTLR3 Monoclonal mouse IgG1 (TLR3.7) Human TLR3 FC, WB 100 μg mab-htlr3 MAb-hTLR3-FITC Monoclonal mouse IgG1 (TLR3.7), FITC Human TLR3 FC, WB 100 μg mab-htlr3f Anti-TLR4 MAb-hTLR4 Monoclonal mouse IgG2a (HTA125) Human/monkey TLR4 FC, IHC 100 μg mab-htlr4 MAb-hTLR4-FITC Monoclonal mouse IgG2a (HTA125), FITC Human/monkey TLR4 FC 100 μg mab-htlr4f MAb-mTLR4/MD2 Monoclonal rat IgG2a (MTS510) Mouse TLR4/MD2 FC, IHC 100 μg mab-mtlr4md2 MAb-mTLR4/MD2-FITC Monoclonal rat IgG2a (MTS510), FITC Mouse TLR4/MD2 FC 100 μg mab-mtlr4md2f Anti-TLR9 MAb-mTLR9 Monoclonal mouse IgG2a (5G5) Human/mouse TLR9 FC, IHC, WB 100 μg mab-mtlr9 MAb-mTLR9-FITC Monoclonal mouse IgG2a (5G5), FITC Human/mouse TLR9 FC 100 μg mab-mtlr9f * FC: flowcytometry; IHC: immunohistochemistry; WB: Western blot Contents and Storage MAb-TLR-IgA and MAb-TLR-IgG antibodies are provided lyophilized from a 0.2 μm filtered solution in PBS. MAb-TLR antibodies are purified and provided as 100 μg lyophilized powder. PAb-TLR antibodies are provided as 200 μg lyophilized sera. PAb-TLRs are sterile, azide-free (contain Pen/Strep), endotoxin-tested (
INNATE IMMUNITY 3 pNiFty - PRR Signaling Reporter Plasmids PRR activation triggers a complex signaling cascade that leads to the activation of different transcription factors, each playing an important role in the subsequent immune response. To monitor the induction of PRR signaling in response to ligand stimulation in a simple and efficient manner, InvivoGen has designed pNiFty, a family of reporter plasmids expressing a reporter gene under the control of a minimal promoter inducible by these different transcription factors, either individually or in combination. Most pNiFty plasmids are selectable with Zeocin in both E. coli and mammalian cells, and can be used to generate stable clones 74 PLASMID NAME Description TRANSCRIPTION FACTOR BINDING SITES pNiFty plasmids are composed of three key elements: a proximal promoter, repeated transcription factor binding sites (TFBS) and a reporter gene. The proximal promoters are shorter than 500 bp and contain transcription factor binding sites. Upon stimulation in 293 cells, their expression level remains undetectable. With the addition of repeated TFBS, the proximal promoters become inducible by the appropriate stimulus and drive the expression of the reporter gene. Minimal promoters - ELAM promoter: the proximal promoter of the endothelial cellleukocyte adhesion molecule (ELAM-1; E-selectin) gene contains three NF-kB sites and is truly NF-kB specific, as it lacks an AP1/CREB site found in the full-length promoter 1, 2 . - IFN-b promoter: the mouse IFN-b minimal promoter comprises several positive regulatory domains that bind different cooperating transcription factors such as NF-kB, IRF3 and IRF7 3 . - ISG-56K promoter: the minimal promoter of the human interferonstimulated gene ISG-56K contains two interferon-stimulated regulatory element (ISRE) sites and is fully inducible by type I IFNs and interferon regulatory factors (IRFs) 4, 5 . Transcription factor binding sites (TFBS) - AP-1 binding site: Activator protein 1 (AP-1) is a transcription factor activated by most PRRs. AP-1 is a heterodimeric complex composed of members of Fos, Jun and, ATF protein families. AP-1 binds to the TPA responsive element (TRE: ; TGAG/CTCA) 6 . AP-1 activation in TLR signaling is mostly mediated by MAP kinases such as c-Jun N-terminal kinase (JNK), p38 and extracellular signal regulated kinase (ERK). MINIMAL PROMOTER www.invivogen.com/innate-immunity-pnifty SELECTION REPORTER CATALOG CODE pNiFty-SEAP NF-kB (x5) ELAM Ampicillin SEAP pnifty-seap pNiFty-Luc NF-kB (x5) ELAM Ampicillin Luciferase pnifty-luc pNiFty2-SEAP NF-kB (x5) ELAM Zeocin SEAP pnifty2-seap pNiFty2-Luc NF-kB (x5) ELAM Zeocin Luciferase pnifty2-luc pNiFty2-56K None ISG56 Zeocin SEAP pnf2-56sp pNiFty3-SEAP NEW None IFN-b Zeocin SEAP pnf3-sp1 pNiFty3-N-SEAP NEW NF-kB (x5) IFN-b Zeocin SEAP pnf3-sp2 pNiFty3-A-SEAP NEW AP-1 (x5) IFN-b Zeocin SEAP pnf3-sp3 pNiFty3-I-SEAP NEW ISRE (x5) IFN-b Zeocin SEAP pnf3-sp4 pNiFty3-T-SEAP NEW NFAT (x5) IFN-b Zeocin SEAP pnf3-sp5 pNiFty3-AN-SEAP NEW AP-1 (x5) NF-kB (x5) IFN-b Zeocin SEAP pnf3-sp6 pNiFty3-IAN-SEAP NEW ISRE (x5) AP-1 (x5) NF-kB (x5) IFN-b Zeocin SEAP pnf3-sp7 pNiFty3-TAN-SEAP NEW NFAT (x5) AP-1 (x5) NF-kB (x5) IFN-b Zeocin SEAP pnf3-sp8 SEAP or Luciferase SEAP or Luciferase
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INNOVATION WITHIN REACH InvivoGen
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CONTENTS AT A GLANCE 1 CELL CULTURE
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4 CYTOKINE SIGNALING TABLE of CONTE
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Mycoplasma Detection & Elimination
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PlasmoTest Contents - HEK-Blue -2
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Primocin - The Antimicrobial Shiel
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SEAP Reporter Gene System Secreted
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HEK-Blue Detection - Real-Time Det
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Blasticidin S Description Blasticid
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LyoVec New formulation LyoVec is
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Poly-Arginine-HA Tagged Reprogrammi
Page 24 and 25: LENTI-Smart - Lentiviral Vector Pr
Page 26 and 27: Lentiviral Vector Production and Ce
Page 28 and 29: Antibody generation using pFUSE-CHI
Page 30 and 31: Engineering Fc regions for altered
Page 32 and 33: pBROAD & pWHERE - Optimized Vector
Page 34 and 35: pSELECT-Tag - Expression of a GFP-,
Page 36 and 37: pVIVO - Expression of Two Genes of
Page 38 and 39: pORF Description pORF plasmids feat
Page 40 and 41: Prom A-List - Human and Rodent Pro
Page 42 and 43: PROMOTER GENE TISSUE DISTRIBUTION S
Page 44 and 45: ChemiComp E. coli ChemiComp E. coli
Page 46 and 47: Fast-Media ® Preparation 1. Empty
Page 48 and 49: RIG-I-like Receptors 54 RLR & RLR-R
Page 50 and 51: Toll-Like Receptors Toll-Like Recep
Page 52 and 53: www.invivogen.com/innate-immunity 5
Page 54 and 55: IPAF and NAIP5 IPAF (NLRC4, CLAN/CA
Page 56 and 57: C-Type Lectin Receptors C-type lect
Page 58 and 59: pUNO pUNO-HA Toll-Like Receptors (T
Page 60 and 61: GENE NAME/ALIASES DESCRIPTION CAT.
Page 62 and 63: pDUO - Gene Associations Features a
Page 64 and 65: pZERO-TLR & pDeNy - Dominant Negati
Page 66 and 67: 293/TLR & 293/NOD Clones 293/TLR Cl
Page 68 and 69: Response of HEK-Blue hTLR2 cells t
Page 70 and 71: Ramos-Blue Cells - NF-kB/AP-1 Repo
Page 72 and 73: MEF Cells C3H/TLR4mut & C3H/WT MEFs
Page 76 and 77: - NF-kB binding site: Nuclear facto
Page 78 and 79: PRODUCT ORIGIN/DESCRIPTION TLR2 Ago
Page 80 and 81: PRODUCT ORIGIN/DESCRIPTION TLR9 Ago
Page 82 and 83: PRODUCT ORIGIN/DESCRIPTION Dectin-1
Page 84 and 85: LPS-PG (Porphyromonas gingivalis) R
Page 86 and 87: • FLA-ST ultrapure was purified b
Page 88 and 89: 1. Zhao H. et al., 2004. Contributi
Page 90 and 91: 1. Hornung V. et al., 2006. 5'-Trip
Page 92 and 93: TLR/NOD Ligand Screening InvivoGen
Page 94 and 95: Signal Transduction Inhibitors Invi
Page 96 and 97: Pepinh-MYD - MyD88 inhibitory pepti
Page 98 and 99: 1. Martinon F,. et al., 2002. The i
Page 100 and 101: Nigericin - NLRP3 Inflammasome Indu
Page 102 and 103: Autophagy is a pathway by which cyt
Page 104 and 105: 4 CYTOKINE SIGNALING Cytokine Genes
Page 106 and 107: Blue Cytokine Reporter Cells Blue
Page 108 and 109: HEK-Blue IFN-a/b Cells - Human Typ
Page 110 and 111: HEK-Blue IL-6 Cells - IL6 Reporter
Page 112 and 113: HEK-Blue IL-1b Cells - IL-1b Repor
Page 114 and 115: HEK-Blue IL-33/IL-1b Cells - IL-33
Page 116 and 117: HEK-Blue CD40L Cells - CD40L Repor
Page 118 and 119: 5 ANTIBODIES & VACCINATION Antibodi
Page 120 and 121: Antibody generation using pFUSE-CHI
Page 122 and 123: Immunoglobulin A The mucosal surfac
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IgA Detection and Quantification In
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IgG Antibodies InvivoGen offers a s
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Mediators? 1. Leroux-Roels G., 2010
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Poly(I:C) Synthetic double-stranded
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pVAC - Induction of Neutralizing An
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CpG-Free DNA CpGs and the Immune Re
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pCpGfree-basic & pCpGfree-promoter
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pCpGfree-siRNA & pCpGfree-siRNADUO
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Custom-Made CpG-Free Genes InvivoGe
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RNA INTERFERENCE 7 psiRNA System I
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RNA INTERFERENCE 7 psiRNA-h7SK - 7S
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RNA INTERFERENCE 7 psiTEST System
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RNA INTERFERENCE 7 Ready-Made psiRN
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RNA INTERFERENCE 7 Custom-Made psiR
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INHIBITORS 8 Inhibitors PRODUCT DES
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INHIBITORS 8 Pattern Recognition Re
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INHIBITORS 8 Triptolide - NF-kB Inh
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INHIBITORS 8 Heat Shock Protein Inh
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9 CUSTOM SERVICES TLR/NOD Ligand Sc
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CUSTOM SERVICES 9 Custom Cloning :
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CUSTOM SERVICES 9 Prices 164 TERMS
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166 PRODUCT (QUANTITY) CAT. CODE PA
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A 17-AAG 17-AAGH2 17-AEP-GA 2-Amino
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- ODN 4084-F - ODN INH-1 - ODN INH-
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ARGENTINA Genbiotech S.R.L. Tel: +5
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