Docetaxel with prednisone or prednisolone for the treatment of ...

Authors: Bennet et al. (1997) 73
Title: A comparison of
perspectives on prostate cancer:
analysis of utility assessments of
patients and physicians
43 physicians (from oncology and urology), 27
patients with localised prostate cancer and 17
patients with metastatic prostate cancer assessed
the QoL of three clinical metastatic prostate
cancer states. The objective was to investigate the
differences between physicians and patients’ values
for the three prostate cancer states.
The three clinical metastatic prostate cancer states
were as follows:
● A = asymptomatic or stable
● B = moderate pain and fatigue with early
evidence of progressive prostate cancer or early
progression
● C = severe pain and fatigue with late
progressive disease or advanced prostate cancer.
These three health states were each comprised
from three levels of five health attributes: pain,
mood, sexual function, bladder and bowel
function and fatigue and energy.
Patients were individually interviewed to identify
the number of years of perfect health that would
be preferred to 10 years with the health state
associated with a particular outcome. Physicians
were asked to identify the fraction of a perfectly
healthy year a typical patient with metastatic
prostate cancer would find equivalent to 1 year in
a less desirable health state, both followed by
Appendix 10
Health Technology Assessment 2007; Vol. 11: No. 2
Summary of quality of life studies considered in
the economic model
TABLE 50 Median (interquartile range) utility scores for physicians and patients
© Queen’s Printer and Controller of HMSO 2007. All rights reserved.
death. Scores were bounded on a scale from 0
(death) to 1 (perfect health).
Results for each clinical metastatic prostate cancer
state in terms of median utility scores and interquartile
ranges for physicians and patients are
presented in Table 50.
In conclusion, the utility rankings differed
between patients and physicians. Patients ranked
severe metastatic disease (state C) as almost
equivalent to death (median score = 0.05),
whereas physicians ranked this state about
intermediate (median score = 0.42) between
perfect health and death. Similarly, for the A and
B health states, physicians appeared more
optimistic in their assessments than patients.
Authors: Chapman et al. (1998) 74
Title: Prostate cancer patients’
utilities for health states: how it
looks depends on where you stand
Fifty-nine prostate cancer patients (with localised
or metastatic disease) were recruited to assess
three hypothetical prostate cancer health states
based on two approaches using TTO.
The health states were described in terms of five
health attributes affected by prostate cancer: pain,
mood, sexual function, bladder and bowel
function and fatigue and energy. Each attribute
had three levels that were used to form three
separate health state descriptions: A = high,
B = moderate and C= low. In addition, patients
also provided an assessment of their own current
health.
A B C
Physicians 0.92 (0.88–0.96) 0.83 (0.67–0.88) 0.42 (0.25–0.58)
Patients: localised disease 0.88 (0.74–0.99) 0.53 (0.38–0.78) 0.05 (0.05–0.48)
Patients: metastatic disease 0.78 (0.78–0.98) 0.58 (0.38–0.78) 0.05 (0.05–0.23)
167