Docetaxel with prednisone or prednisolone for the treatment of ...

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58 TABLE 33 Economic model Quality of life summary results table Study Method Health state Source of values and results TTO A = mild Physicians (median), A = 0.92; B = 0.83; C = 0.42 B = moderate Patients with localised prostate cancer (median), A = 0.88; B = 0.53; C = 0.05 C = severe Patients with metastatic prostate cancer (median), A = 0.78; B = 0.58; C = 0.05 Bennet (1997) 73 TTO A = mild Patients in personal version (mean), A = 0.78; B = 0.72; C = 0.35 B = moderate Patients in impersonal version (mean), A = 0.78; B = 0.51; C = 0.20 C = severe Chapman (1998) 74 TTO A = mild Patients with localised or metastatic prostate cancer (mean), A = 0.84; B = 0.66; B = moderate C = 0.23 C = severe Chapman (1999) 75 PORPUS, HUI, A = metastatic disease Patients with metastatic disease: PORPUS – SG (mean), A = 0.85 QWB B = non-metastatic disease Patients with metastatic disease: PORPUS – RS (mean), A = 0.75 Patients with non-metastatic disease: PORPUS – SG (mean), B = 0.86 Patients with non-metastatic disease: PORPUS – RS (mean), B = 0.80 Krahn (2003) 76 Community: HUI (mean), A = 0.81; B = 0.80 Community: QWB (mean), A = 0.62; B = 0.66 Sandblom (2004) 77 EQ-5D Time of death (0–4 months) Value score (mean) = 0.46; VAS score (mean) = 0.45 Time of death (4–8 months) Value score (mean) = 0.52; VAS score (mean) = 0.53 Time of death (8–12 months) Value score (mean) = 0.58; VAS score (mean) = 0.57 Average (0–12 months) Value score (mean) = 0.538; VAS score (mean) = 0.54 TTO A = hormonally responsive Husbands (mean), A = 0.72; B = 0.55 B = hormone refractory Wives (mean), A = 0.86; B = 0.66 Couples (mean), A = 0.83; B = 0.62 Volk (2004) 78 SG A = cancer with 20% chance of tumour spread Patients (mean), A = 0.84; B = 0.81; C = 0.71; D = 0.67; E = 0.25 B = cancer with 40% chance of tumour spread C = cancer with 70% chance of tumour spread D = cancer with tumour spread E = terminal disease Stewart (2005) 79 EQ-5D, EuroQol instrument; HUI, Health Utilities Index; PORPUS, Patient Oriented Prostate Utility Scale; QWB, Quality of Well Being Scale; RS, rating scale; SG, standard gamble; TTO, time trade-off; VAS, visual analogue scale.
Localised Metastatic mHRPC Bennet (1997) A B C TTO (median) 0.92 0.83 0.42 Physicians (n = 47) 0.88 0.53 0.05 Localised PC (n = 27) 0.78 0.58 0.05 Metastatic PC (n = 17) Chapman (1998) A B C TTO (mean) 0.78 0.51 0.2 Impersonal (n = 31) 0.78 0.72 0.35 Personal (n = 28) Chapman (1999) A B C TTO (mean) 0.84 0.66 0.23 Patient (n = 57) Krahn (2003) RS & SG (mean) 0.86 0.85 Patient PORPUS – SG (n = 141) 0.80 0.75 Patient PORPUS – RS (n = 141) 0.80 0.81 HUI – SG 0.66 0.62 QWB – RS © Queen’s Printer and Controller of HMSO 2007. All rights reserved. Health Technology Assessment 2007; Vol. 11: No. 2 Sandblom (2004) 12–8M 8–4M 4–0M EQ-5D (mean) 0.58 0.54 0.46 Value 0.57 0.53 0.45 VAS Volk (2004) TTO (mean) 0.72 0.55 Husbands (n = 168) 0.86 0.66 Wives (n = 168) 0.83 0.62 Couples (n = 168) Stewart (2005) SG (mean) 0.84 0.81 0.71 0.67 0.25 Patients (n = 162) FIGURE 5 Spectrum of HRQoL’s utility values for prostate cancer 59
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A systematic review and economic mo
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A systematic review and economic mo
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Objectives: A systematic review was
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Glossary and list of abbreviations
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Glossary Absolute risk reduction Th
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Glossary continued Expected value o
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Glossary continued Progression-free
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List of abbreviations ASCO American
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xvi Executive summary of study desi
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xviii Executive summary prednisone/
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Description of underlying health pr
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● Patients with severe fluid rete
Page 27 and 28: Search strategy As stated in Chapte
Page 29 and 30: consensus and, if necessary, a thir
Page 31 and 32: Quantity of research available A to
Page 33 and 34: TABLE 1 Summary of included RCTs St
Page 35 and 36: TABLE 2 Treatment comparisons relat
Page 37 and 38: tumour response was reported for on
Page 39 and 40: TABLE 4 Summary results table for d
Page 41 and 42: decrease in PSA level (51 and 39% c
Page 43 and 44: Survival (%) 100 80 60 40 20 0 0 co
Page 45 and 46: TABLE 8 Summary results table for d
Page 47 and 48: TABLE 9 Grade 3 or 4 adverse events
Page 49 and 50: Also used was the core questionnair
Page 51 and 52: these, 69 patients had measurable t
Page 53 and 54: Effectiveness of mitoxantrone plus
Page 55 and 56: over to receive additional mitoxant
Page 57 and 58: Progression-free survival It is not
Page 59 and 60: compared with corticosteroids. The
Page 61 and 62: statistically significant improveme
Page 63 and 64: Summary of studies included in the
Page 65 and 66: TABLE 19 Percentage of costs by res
Page 67 and 68: TABLE 21 Summary of submission by S
Page 69 and 70: TABLE 24 Other in-trial costs a bod
Page 71 and 72: TABLE 27 Cost-effectiveness results
Page 73 and 74: Introduction The review of cost-eff
Page 75 and 76: TABLE 28 Regression coefficients fr
Page 77: cancer QoL estimation. Studies whic
Page 81 and 82: TABLE 34 Unit costs of drugs from t
Page 83 and 84: were assigned to the total follow-u
Page 85 and 86: Probability cost-effective given da
Page 87 and 88: Probability cost-effective given da
Page 89 and 90: TABLE 43 Utility values including/e
Page 91 and 92: was set to be 1.5 years based on th
Page 93: Population value of implementation/
Page 96 and 97: 76 Discussion (CCI-NOV22) and least
Page 98 and 99: 78 Discussion subsequent chemothera
Page 101: Rodolphe Perard received funding fr
Page 104 and 105: 84 References Compendium; 2004. URL
Page 106 and 107: 86 References (D) in patients (pts)
Page 108 and 109: 88 References 100. Aventis Pharma.
Page 110 and 111: 90 References low-dose prednisone i
Page 112 and 113: 92 References 180. Kozloff M, Robin
Page 114 and 115: 94 References locally advanced pros
Page 116 and 117: 96 References 251. Scholz MC, Guess
Page 119 and 120: Clinical effectiveness Searching fo
Page 121 and 122: 1. Prostatic Intraepithelial Neopla
Page 123 and 124: 19. donataxel 20. doxetal 21. doxmi
Page 125 and 126: 6. Mitozantrone.ti,ab. 7. Mitoxantr
Page 127 and 128: Texot or Trazoteva or Trixotene or
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1. (docetaxel OR asodecel OR doxeta
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10. (index of wellbeing or quality
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Appendix 2 Excluded studies Study d
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Study details Reason for exclusion
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Meeting: 2004 ASCO Annual Meeting C
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Studies of clinical effectiveness w
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Using the method outlined by Parmar
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Appendix 6 Data extraction tables
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Study details and Participant detai
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158 Appendix 7 Ernst et al. 33 Qual
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Appendix 9 © Queen’s Printer and
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Sanofi-Aventis 61 Bloomfield et al.
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Sanofi-Aventis 61 Bloomfield et al.
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168 Appendix 10 TABLE 51 Mean (SD)
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170 Appendix 10 TABLE 54 Distributi
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172 Appendix 10 TABLE 57 Mean stand
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174 Appendix 11 TABLE 63 Drug and a
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176 Appendix 12 Scenario: moderate
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178 Appendix 13 ● You occasionall
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Members Chair, Professor Tom Walley
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Members Chair, Professor Bruce Camp
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Feedback The HTA Programme and the
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